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  • 1
    Electronic Resource
    Electronic Resource
    Pretreatment with opioids (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 41 (1986), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pretreatment with small doses of fentanyl (fO0 jig) or alfentanil (300 pg) was found significantly to reduce the induction dose of thiopentone. Fentany 150 μp and alfentanil 150 pg also signifcantly reduced the onset time and increased the consistency of action of midazolam. Respiratory depression was not a problem when 50 pg fentanyl or 150 pg alfentanil were used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1986.tb13172.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The peri-operative use of the oesophageal Doppler monitor in patients undergoing coronary artery revascularisation#A comparison with the continuous cardiac output monitor (1997)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was carried out to evaluate the ease of use and reliability of cardiac output estimations performed by an oesophageal Doppler monitor and to compare its use with that of a continuous cardiac output pulmonary flotation catheter. Measurements were made during and after surgery in 16 patients scheduled to undergo coronary revascularisation. Both devices suffered significant intra-operative problems which led us to question their suitability as operating theatre monitors. After surgery the continuous cardiac output monitor provided stable results while the oesophageal Doppler monitor required the continuous presence of an experienced anaesthetist to ensure comparable cardiac output estimations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1997.147-az0151.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Extradural anaesthesia in parturients with severe cardiovascular disease (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 37 (1982), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The use of extradural block (EDB) in healthy parturients for normal delivery and operative procedures is now a widespread and established practice. However, clinical reports of its use in those parturients with severe cardiovascular disease are rare. Here we present two case reports of patients with severe cardiovascular disease delivered under EDB and discuss the merits of this method of anaesthetic management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1982.tb01156.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Propofol sedation after open heart surgery A clinical and pharmacokinetic study (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 45 (1990), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One hundred adult patients who required mechanical ventilation after open heart surgery for coronary revascularisation were studied. All received a standard premedication and a high dose opioid anaesthetic. On arrival in the intensive care unit they were allocated randomly to receive either propofol or midazolam to maintain sedation within a predetermined range. Patients who received propofol underwent extubation of the trachea, using standard criteria, after a mean time (log-transformed) of 7.6 minutes after sedation for approximately 17 hours. The corresponding time was 125 minutes in those given midazolam. There were significantly higher morphine requirements during sedation, and higher arterial carbon dioxide tensions 30 minutes after extubation of the trachea, in patients who received midazolam. Pharmacokinetic analysis in 20 patients showed that the elimination half-life of propofol was prolonged (470 minutes) and clearance was reduced (1.14 litres/minute) compared with subjects who had not undergone cardiopulmonary bypass. The rapid clinical recovery was reflected in a rapid redistribution half-life (13.4 minutes), but this was also longer than the redistribution time of 2–4 minutes in other patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1990.tb14743.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Prolonged high frequency jet ventilation and milrinone therapy following modified Fontan procedure (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An 11-year-old boy who underwent a modified Fontan procedure required surgical re-exploration the next day. Profound cardiogenic shock developed and he required high frequency jet ventilation and milrinone therapy for 15 days. After 11 days of high frequency jet ventilation he developed a tracheal mucous plug leading to a hypoxic cardiac arrest from which he was successfully resuscitated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1994.tb14181.x
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  • 6
    Electronic Resource
    Electronic Resource
    Propofol-fentanyl anaesthesia in cardiac surgery: a comparison in patients with good and impaired ventricular function (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 48 (1993), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The haemodynamic effects of propofol-fentanyl anaesthesia for elective cardiac surgery were compared in 24 patients with good left ventricular function (ejection fraction 〉 45%, left ventricular end-diastolic pressure 〈 16 mmHg) and nine patients with impaired function. Anaesthesia was induced withfentanyl 25 μg.kg−1 and pancuronium 0.1 mg.kg−1 and was maintained with a variable rate propofol infusion, mean rate 2.61 mg.kg−1.h−1 in the good ventricular function group and 2.71 mg.kg−1.h−1 in the impaired function group. Additional fentanyl 7.5 μg.kg−1 was given before sternotomy. Ventilation to normocarbia was with air and oxygen (Fio2 0.6). Haemodynamic measurements were made before induction, after tracheal intubation, before and after sternotomy and before aortic cannulation. There were no significant differences between the groups in any haemodynamic variables during the study. Twenty minutes after intubation both groups showed a decrease from pre-induction values in mean arterial pressure (p 〈 0.05) and left ventricular stroke work index (p 〈 0.05), the reduction in left ventricular stroke work index remaining significant during the prebypass period in both groups. There were no significant changes in right or left sided filling pressures, systemic vascular resistance or heart rate. The technique decreased cardiac work and effectively controlled the autonomic responses to sternotomy in both groups. This study suggests that propofol may be a suitable adjunct to opioid anaesthesia in patients with impaired ventricular function having cardiac surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1993.tb07173.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Propofol sedation using DiprifusorTM target-controlled infusion in adult intensive care unit patients (2004)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 59 (2004), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This multicentre, non-comparative study investigated the range of target blood propofol concentrations required to sedate 122 adult intensive care patients when propofol was administered using DiprifusorTM target-controlled infusion systems together with opioid analgesia. Depth of sedation was assessed with a modified Ramsay score and the target blood propofol setting was adjusted to achieve the sedation desired for each patient. A desired level of sedation was achieved for 84% of the sedation period. In postcardiac surgery patients the median time-weighted average propofol target setting was 1.34 μg.ml−1 (10th – 90th percentiles: 0.79–1.93 μg.ml−1). Values in brain injured and general ICU patients were 0.98 (10th – 90th percentiles: 0.60–2.55) μg.ml−1 and 0.42 (10th – 90th percentiles: 0.16–1.19) μg.ml−1, respectively. Measured propofol concentrations were generally close to values predicted by the DiprifusorTM system. Target settings in the range of 0.2–2.0 μg.ml−1 are proposed for propofol sedation in this setting with titration as required in individual patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2004.03745.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of aprotinin on interleukin-8 concentration and leukocyte adhesion molecule expression in an isolated cardiopulmonary bypass system (1999)
    Oxford : Blackwell Science Ltd
    Anaesthesia 54 (1999), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We examined the effect of aprotinin on the production of interleukin-8 and the expression of leukocyte adhesion molecules in an isolated cardiopulmonary bypass circuit. Five healthy volunteers each donated 500 ml blood which was divided into equal portions (A) and (B). Portion A was treated with aprotinin 250 000 kallikrein inactivator units and added to a circuit primed with a further 250 000 kallikrein inactivator units. Portion B was simultaneously treated with 25 ml normal saline and added to an aprotinin-free circuit. Samples of blood were taken at donation, after addition of a drug and at 30-min intervals throughout isolated cardiopulmonary bypass. The interleukin-8 increase was smaller in the aprotinin group but the difference between groups was not statistically significant (p 〉 0.05). In contrast, aprotinin inhibited the cardiopulmonary bypass-induced increase in monocyte (p 〈 0.05) and granulocyte (p 〈 0.01) CD18 and the increase in granulocyte, but not monocyte, CD11b (p 〈 0.05). Cardiopulmonary bypass had little effect on expression of L-selectin. These results confirm that aprotinin attenuates leukocyte activation during isolated cardiopulmonary bypass.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2044.1999.00656.x
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    Paper (German National Licenses)
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