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  • 1
    Electronic Resource
    Electronic Resource
    The effects of thiopentone and propofol on delayed hypersensitivity reactions (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 50 (1995), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of thiopentone and propofol on delayed hypersensitivity reactions and T lymphocyte proliferation were studied in nine healthy volunteers (five women and four men). Thiopentone 5 mg.kg-1 and propofol 2.5mg kg-1 were given as a 10 min infusion on two separate occasions. The volunteers were exposed to a skin multitest antigen before and after administration of the two agents and their skin reactions assessed. T lymphocyte responses were studied using phytohaemagglutinin (PHA)-induced proliferation. Results showed that both drugs caused a significant depression of skin reactions in vivo but no depression in the T lymphocyte proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1995.tb06037.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunoglobulin isotype composition of circulating and intra-articular immune complexes in patients with inflammatory joint disease (1991)
    Springer
    Rheumatology international 11 (1991), S. 169-174 
    Details
    ISSN: 1437-160X
    Keywords: Immune complexes ; Immunoglobulin isotypes ; Rheumatoid arthritis ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunoglobulin (Ig) heavy chain isotype composition of intra-articular and circulating immune complexes (ICs) were determined by a Raji cell flow cytometric assay in paired serum and synovial fluid samples from 15 patients with rheumatoid arthritis (RA) and 15 patients with other articular diseases (osteoarthritis, ankylosing spondylitis, gout, psoriatic arthritis, Reiter's discase). ICs were most prevalent in synovial fluid samples of patients with RA but were infrequently detected in serum and synovial fluid samples from the non-RA patients. ICs in patients with RA were heterogeneous both in the prevalence of Ig subclasses identified and in the distribution of the respective Ig isotypes within the complexes. Furthermore, differences were observed in the Ig isotype composition of ICs in paired serum and synovial fluid samples in dicating that circulating ICs may not always arise simply by spill-over from articular sites. The possible mechanisms for IC formation in RA are discussed with reference to four patients who displayed features of extra-articular disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332556
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  • 3
    Electronic Resource
    Electronic Resource
    Mouse granulocyte precursors and multiple sclerosis (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 778-778 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-Brown and Gajdusek1 have recently reported failure to reproduce the suppression of peripheral blood granu-locytes which was described2 in mice following inoculation of material from patients with multiple sclerosis (MS). We have also studied the effect on groups of ten weaning C57BL and CBA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249778a0
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  • 4
    Electronic Resource
    Electronic Resource
    Density distribution analysis of In vivo and In vitro colony forming cells in developing fetal liverPublication 1323 from The Walter and Eliza Hall Institute.This work was supported by grants from The National Health and Medical Research Council, Canberra, and the Australian Research Grants Committee. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 75 (1970), S. 181-192 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The technique of buoyant density separation in gradients of Bovine Serum Albumin has been used to separate in vivo and in vitro colony forming cells (C.F.C.'s) in hemopoietic tissue of mouse fetal liver. Differences in the density distribution profiles showed that the in vivo and in vitro C.F.C.'s were different cell populations but the existence of an “out-of-phase” density association suggested that the two cell types were closely related.Complex density heterogeneity of both cell populations was observed at later stages of liver development and was similar to that seen in adult marrow. A homogeneous population of in vivo and in vitro C.F.C.'s occupied a very light density position in 10.5 day fetal liver. The subsequent development of density heterogeneity was associated with progressive acquisition of higher density subpopulations. Transfer experiments showed the capacity of the lightest density cells from the earliest stage of liver hemopoiesis, to generate higher density colony forming cells in the environment of the adult marrow. Density determined differences in seeding efficiency of in vivo C.F.C.'s were observed but no evidence was obtained for differences in either in vivo or in vitro colony morphology in different density subpopulations.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040750207
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  • 5
    Electronic Resource
    Electronic Resource
    Cellular responsiveness to stimulation in vitro: Strain differences in hemopoietic colony forming cell responsiveness to stimulating factor and suppression of responsiveness by glucocorticoids (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 82 (1973), S. 49-58 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Granulocyte-macrophage colony formation from bone marrow cells in soft agar is dependent upon the presence of a stimulating factor and the number of colonies is related to its concentration. This dose-response effect provided a measurement of the responsiveness to stimulation of colony forming cell populations in marrows from different sources. There were significant differences between the responsiveness of cells from different strains of mice which paralleled the previously observed myelopoietic and immune responsiveness of these strains to stimulation in vivo.Low concentrations of hydrocrotisone reduced the responsiveness of colony forming cells (a) when added to cultures of normal marrow or (b) when cells were taken from hydrocortisone-treated mice and cultured in its absence. The reduction which followed inoculation was not apparent until the 4th day and occurred irrespective of mouse strain, type of drug or route of inoculation and with a dose (100 μg) which did not affect the actual number of colony forming cells in the marrow.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040820106
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  • 6
    Electronic Resource
    Electronic Resource
    Density distribution analysis of In vivo and In vitro colony forming cells in bone marrowPublication 1350 from The Walter and Eliza Hall Institute.This work was supported by grants from the National Health and Medical Research Council, Canberra, and the Australian Research Grants Committee. (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 75 (1970), S. 167-179 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The technique of buoyant density separation in gradients of Bovine Serum Albumin has been used to separate hemopoietic cell populations in mouse bone marrow that form in vivo spleen colonies and in vitro colonies of granulocytes and macrophages in an agar culture system. The density distribution profiles showed a number of reproducible density subpopulations of both in vivo and in vitro colony forming cells (C.F.C.'s). The mean density of in vitro C.F.C.'s exceeded that of the in vivo but overlap of the density profiles of the two populations was evident. Density-related differences in seeding efficiency of in vivo C.F.C.'s were observed.Freund's adjuvant treatment increased marrow and spleen in vitro C.F.C. populations. Marrow density profiles obtained three and seven days after adjuvant showed a progressive increase in in vitro C.F.C.'s in a restricted density region with no associated elevation of in vivo activity.The antimitotic agent, vinblastine, revealed differences in mitotic activity between the two cell populations, reducing the in vitro C.F.C. population to .07% and the in vivo to 5% of normal in 24 hours. Density separation of vinblastine-treated marrow produced density regions devoid of in vitro activity but containing in vivo in vivo C.F.C.'s which, upon transfer to irradiated recipients, regenerated both in vivo and in vitro density distribution profiles.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040750206
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  • 7
    Electronic Resource
    Electronic Resource
    Cellular responsiveness to stimulation in vitro: Increased responsiveness to colony stimulating factor of bone marrow colony-forming cells treated with surface-active agents and cyclic 3′5′ AMP (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 88 (1976), S. 323-329 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Addition of low concentrations (10 ng/ml) of saponin or Tween 80 to stimulated cultures of normal mouse bone marrow in agar increased the number of granulocyte-macrophage colonies which developed. Addition of cyclic AMP or dibutyryl cyclic AMP in low concentration (10-8 to 10-10 M) also enhanced colony numbers although concentrations above 10-5 M were inhibitory. Enhancement was found when marrow cells were pre-treated with these agents and cultured in their absence.The agents did not stimulate colony development in the absence of colony-stimulating factor and enhancement of colony number occurred only in cultures containing a concentration of colony-stimulating factor which was sub-optimal in terms of maximum colony development.There was no indication of increased colony-stimulating factor production by treated marrow cells under the experimental conditions used to show colony enhancement. It was concluded that the agents caused an increased responsiveness of colony-forming cells to colony-stimulating factor.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040880308
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