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  • 1
    Electronic Resource
    Electronic Resource
    Efficacy and safety of two different galenic formulations of a transdermal clonidine system in the treatment of hypertension (1993)
    Springer
    Clinical autonomic research 3 (1993), S. 373-378 
    Details
    ISSN: 1619-1560
    Keywords: Clonidine ; Transdermal ; Hypertension ; Compliance ; Blood pressure ; Skin reactions ; Galenic formulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The efficacy and safety of two different galenic formulations of transdermal clonidine systems were compared in 905 patients with mild to moderate essential hypertension during a 12 weeks observation period. 449 patients were treated with the matrix controlled clonidine transdermal (C-TD) system and 456 patients with the membrane controlled clonidine system (C-TTS). The mean blood pressure was reduced from 168/102 mmHg to 146/87 mmHg in the C-TD and from 169/102 mmHg to 148/88 mmHg in the C-TTS group. There was no difference in the response rate. The pattern of systemic side-effects appeared to correspond to those seen during oral clonidine treatment but with a lower frequency and intensity. The C-TD patch improved skin tolerability and the drop-out rate due to skin reactions was 2.2 times lower compared with the C-TTS group. Local skin reactions led to withdrawal in 35 of 449 C-TD treated and in 79 of 456 C-TTS treated patients. In conclusion, the improved carrier system for the transdermal clonidine treatment reduced local side-effects which in turn may further enhance acceptability and compliance in treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01829456
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term (5 year) experience with transdermal clonidine in the treatment of mild to moderate hypertension (1993)
    Springer
    Clinical autonomic research 3 (1993), S. 385-390 
    Details
    ISSN: 1619-1560
    Keywords: Transdermal ; Clonidine ; Hypertension ; Longterm treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The long-term safety and efficacy of transdermal clonidine (C-TTS) was evaluated in 102 patients with mild to moderate hypertension over a mean treatment period of 4.9 ± 1.4 years. C-TTS size 1 was used by 29.4%, C-TTS size 2 by 35.3%; in 35.3% of the patients a diuretic agent was given in addition. The baseline blood pressure of 168/100 mmHg was reduced to 150/85 mmHg at the end of titration and remained stable during long-term treatment. After 5 years seated blood pressure was 147/83 mmHg. Systemic side-effects, e.g. 4.9% dry mouth, were reported mainly during the first month. Transient local side-effects occurred mainly between weeks 4–26, thereafter the incidence clearly diminished and did not cause any withdrawal due to skin reactions from 1 year up to 6.5 years. Overall the long-term transdermal clonidine treatment was highly accepted by the patients, was effective and was well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01829458
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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