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  • 1
    Electronic Resource
    Electronic Resource
    Nachweis einer erhöhten Glucose-6-phosphatdehydrogenase-Aktivität der Erythrocyten mittels Farbreaktion (1964)
    Springer
    Journal of molecular medicine 42 (1964), S. 1028-1030 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Determination of the G-6-PD of erythrocytes was performed with the spectrophotometric method and with the aid of the Motulsky-test modified according toTönz andBetke. The results obtained confirmed that the simple Motulsky-test produces satisfactorily quantitative results. In 350 blood samples of haematologically healthy persons the Motulsky-test revealed a mean value of 5.2 U with a standard deviation (2s) of 2.6–7.8 U. In 312 persons with thalassaemia minor mean activity was found to be 7.6 U with a standard deviation of 2.4–12.8 U. Increased G-6-PD activity was observed with different haemoglobinopathies and with acquired anaemias showing a reduced mean red cell age. In anaemias of unknown origin the determination of the G-6-PD is a useful rapid screening test permitting quite often to differentiate between red cell loss and reduced red cell production.
    Notes: Zusammenfassung Vergleichende Bestimmungen der G-6-PD-Aktivität bei 56 Blutproben mit dem vonTönz u.Betke modifizierten Motulsky-Test und spektrophotometrischer TPNH-Messung bestätigten, daß der einfache Farbtest brauchbare quantitative Resultate liefert. Bei 350 hämatologisch gesunden Personen ergab der Motulsky-Test eine mittlere Fermentaktivität von 5,2 E mit einer doppelten Standardabweichung von 2,6–7,8 E. Die Verteilung der Werte entsprach einer Gaußschen Kurve. Bei 312 Fällen von Thalassaemia minor betrug die durchschnittliche Aktivität 7,8 E und der Bereich der doppelten Standardabweichung 2,4–12,8 E. Auch bei andern Hämoglobinopathien und bei erworbenen hämolytischen und sonstigen hyperregeneratorischen Anämien konnten erhöhte G-6-PD-Werte nachgewiesen werden. Eine erhöhte G-6-PD-Aktivität zeigt ein vermindertes Durchschnittsalter der Erythrocytenpopulation an. Die G-6-PD-Bestimmung ermöglicht bei vielen unklaren Fällen eine Unterscheidung von hyper- und hyporegeneratorischen Anämien.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01479448
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  • 2
    Electronic Resource
    Electronic Resource
    The Influence of methaemoglobin on glutathione reductase in erythrocytes
    Amsterdam : Elsevier
    Clinica Chimica Acta 13 (1966), S. 269-272 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(66)90204-X
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  • 3
    Electronic Resource
    Electronic Resource
    Anal endosonography after sphincter repair: specific patterns related to clinical outcome (1999)
    Springer
    Abdominal imaging 24 (1999), S. 569-573 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Endosonography—Anal sphincter—Incontinence—Sphincter repair.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: This study evaluates the endosonographic patterns of the anal sphincter after sphincteroplasty to define specific postoperative findings and to identify factors related to clinical outcome after sphincter repair. Methods: Thirty-one incontinent patients (29 women, two men; mean age = 57 years) who underwent surgical repair for an external sphincter defect were studied postoperatively by endosonography. Twenty patients were found to improve after surgery. Results: Postoperative endosonograms showed specific images: direct visualization of the surgical process was represented by the “overlapping sign” in 17 cases and the “end-to-end suture” in four cases. These echographically favorable cases were associated with improvement after surgery in 18 of 21 patients (p 〈 0.005). Persistent defects were reduced in five patients and unchanged in five other patients and were associated with poor outcome in eight of 10 patients (p 〈 0.005). Conclusions: Postoperative endosonography of the external anal sphincter presented some specific endosonographic aspects. The association between anal endosonographic findings and clinical outcome suggests the use of this procedure to assess patients following sphincteroplasty.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900565
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  • 4
    Electronic Resource
    Electronic Resource
    Alcohol-induced bone marrow damage: Status before and after a 4-week period of abstinence from alcohol with or without disulfiram (1989)
    Springer
    Annals of hematology 59 (1989), S. 231-236 
    Details
    ISSN: 1432-0584
    Keywords: Alcohol ; Bone marrow ; Disulfiram
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The investigation described in this paper has confirmed the existence of alcohol-induced bone marrow damage as a nosological entity in alcohol-dependent individuals. In our patients total abstinence from alcohol without disulfiram or similar drugs led to reversal of the pathological findings in peripheral blood and in bone marrow. In patients undergoing detoxification while taking disulfiram, on the other hand, the pathological bone marrow findings, especially erythropoiesis associated with impaired iron utilization, persisted. The metabolic pathway of disulfiram is discussed. It is probably justifiable to assume that the toxin responsible for alcohol-induced bone marrow damage is the ethanol metabolite acetaldehyde. The persistence of erythropoiesis with impaired iron utilization during abstinence from alcohol and treatment with disulfiram is also of importance in differential diagnosis from the myelodysplastic syndrome (MDS), and especially from refractory anaemia with ring sideroblasts (RARS). For this reason, where the situation is unclear, it is essential that a diagnosis of MDS be supported by specific investigations such as cell cultures, cytogenetic analyses, etc. It is the first time that the toxic, alcohol-like-effect of disulfiram on haematopoiesis is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320853
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  • 5
    Electronic Resource
    Electronic Resource
    Results of sphincteroplasty in 86 patients with anal incontinence (2000)
    Springer
    Diseases of the colon & rectum 43 (2000), S. 813-820 
    Details
    ISSN: 1530-0358
    Keywords: Fecal incontinence ; Sphincteroplasty ; Sphincter defect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was designed to analyze critically the short-term and long-term outcome of sphincteroplasty and to identify high-risk factors. METHODS: Eighty-six patients with fecal incontinence associated with an ultrasound defect of the external anal sphincter were treated by anal sphincteroplasty. Clinical and physiologic assessment was made before surgery, and clinical evaluation was made three months and an average of 40 months after surgery. RESULTS: The evaluation of 86 patients three months after surgery showed that 42 patients were totally continent (49 percent), 28 were incontinent for gas (33 percent), and 16 still had fecal incontinence (19 percent). Seventy-four patients (86 percent) were contacted 40 months after surgery. Twenty-one patients (28 percent) were totally continent, 17 were incontinent to gas (23 percent), and 36 were incontinent to feces (49 percent). Forty-six percent of patients felt they were clearly improved after surgery. Poor results were associated with an internal anal sphincter defect. CONCLUSIONS: Our study suggests that in the long term, one-third of patients are totally continent after sphincteroplasty. One-half of patients are satisfied, but only if their incontinence to feces has totally disappeared. Results of sphincteroplasty deteriorate with time. One factor in poor prognosis is the presence of an associated defect of the internal anal sphincter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238020
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  • 6
    Electronic Resource
    Electronic Resource
    Results of pudendal nerve neurolysis-transposition in twelve patients suffering from pudendal neuralgia (1999)
    Springer
    Diseases of the colon & rectum 42 (1999), S. 186-192 
    Details
    ISSN: 1530-0358
    Keywords: Chronic anoperineal pain ; Vulvodynia ; Pudendal canal syndrome ; Pudendal neuralgia ; Nerve block ; Pudendal canal decompression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: Pudendal neuralgia caused by nerve compression may be improved by surgical decompression of the pudendal nerve. This study was undertaken to determine if clinical symptoms, electrophysiological investigations, and the efficacy of preoperative pudendal nerve blocks could be used to predict the efficacy of surgery. METHODS: Twelve consecutive patients complaining of anal pain, genital pain, or both, exacerbated in the sitting position and unsuccessfully treated by analgesic drugs before referral were studied. In these 12 patients decompression of the pudendal nerve was performed after unsuccessful CT-guided injection of corticosteroids in the pudendal nerve at the ischial spine or after pain relapse following successful injections. Nineteen nerves were decompressed by surgery, and the compressed area was located between the sacrospinal and sacrotuberal ligaments for 18 nerves. RESULTS: Three months after surgery, four patients were totally relieved, and three were only partially improved. After 21 months of follow-up, three patients were cured, one was slightly improved, and eight remained in pain. In the three patients cured by surgery, pain completely disappeared for at least two weeks after a nerve block repeated twice before surgery, whereas pain relief was observed in only one of the nine other patients (P=0.018). None of the three patients cured by surgery were being treated for depression, whereas six of the nine remaining patients were receiving antidepressants or were followed by a psychiatrist (P=0.09). Results of surgery did not depend on other preoperative clinical or electrophysiological data. CONCLUSIONS: This preliminary study suggests that complete disappearance of pain for at least two weeks after a nerve block repeated twice before surgery may be the best criterion to predict success. Based on this criterion, surgery would have been performed in four patients in this study, of whom three would have been cured.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02237125
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  • 7
    Electronic Resource
    Electronic Resource
    Distal Gastrectomy and Roux-Y Limb in the Rat (2000)
    Springer
    Digestive diseases and sciences 45 (2000), S. 1525-1530 
    Details
    ISSN: 1573-2568
    Keywords: Roux-Y limb ; duodenojejunal motility ; motilin ; pancreatic polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After gastrectomy, Roux-Y limb reconstruction leads to duodenojejunal motor disturbances. Because motilin and pancreatic polypeptide (PP) play a role in the regulation of digestive motility, their plasma concentrations were determined in rats after Roux-Y gastrectomy. Three months after a distal Roux-Y gastrectomy, coupling of electromyographic recordings and jugular samples were used to perform motilin and PP radioimmunoassays during and between activity fronts (AFs) occurring in the limb and in the duodenojejunum, 20, 40, and 60 min after intragastric instillation of a standard meal (5 ml Realmentyl). Animals that underwent a simple laparotomy, animals having isolated jejunal transection, and animals with Billroth I gastrectomy (BI group) served as control groups. After Roux-Y gastrectomy, the number of AFs in the limb (P 〈 0.01) and in the duodenum (P 〈 0.001) was reduced compared to laparotomized rats and the BI group, but did not differ from the number in the Tr group. In the limb, AFs were incompletely propagated or were retrograde in 9 and 3 of 20 animals, respectively. After Roux-Y gastrectomy, motilin concentrations occurred at the same time as each duodenal AF, and as in controls, and were independent from AFs in the limb. Plasma motilin concentrations were higher after Roux-Y reconstruction than in control groups (P 〈 0.03), and PP level concentrations were not different. After the meal, the interruption of AFs was shorter in Roux-Y reconstruction than in laparotomized and transected animals (P 〈 0.05) and than in BI group, with no significant difference in the latter. In all groups, plasma motilin and PP concentrations were decreased (P 〈 0.05) and increased (P 〈 0.001), respectively, after the meal compared to the interdigestive period. After Roux-Y gastrectomy, plasma motilin and PP levels were higher (P 〈 0.05) and lower (P 〈 0.05), respectively, compared to controls. In conclusion, AFs in the Roux-Y limb were not associated with plasma motilin concentrations, suggesting a lack of influence of motilin on the interdigestive motor status. The decrease in postprandial plasma PP concentrations may play a role in the shorter interruption of AFs after a meal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005548524334
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