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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 99 (1989), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Intracratonic sag sedimentary basins occur in the middle of stable continental or cratonic blocks. They are rarely fault bounded, although strike-slip faulting can occur within them. A simple model for the development and evolution of these basins is proposed. The mechanism is driven by mildly-coupled convective down-welling of the asthensophere beneath the lithosphere. Initially, a rapid alteration of the mantle convective system causes a descending plume to develop. A depression, which can be of the order of 600 m, can be formed at the earth's surface; this depression, when loaded with sediment, will form a sedimentary basin of the order of 2.5 km thick. If the convective downwelling remains, a period of thermal cooling of the lithosphere occurs, which is similar to the thermal cooling subsidence phase of passive continental margins. This thermal cooling occurs because of the thermal anomaly (temperature decrease) beneath the lithosphere caused by the convective downwelling. If a change of convective pattern occurs and the descending plume is removed, the basin will undergo uplift and erosion, whereby a significant thickness of the sedimentary basin can be removed. The Ordovician and Silurian tectonic development of the Canning Basin, Western Australia, appears to be well explained by this model.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 21 (1982), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Since 1971 over 100 specimens of the oriental goby, Acanthogobius flavimanus, have been collected from New South Wales’ waters. When this species, a native of Japan, was introduced to San Francisco Bay (U.S.A.) it underwent a population explosion, becoming a common member of estuarine fish communities in that area.The occurrence of both reproductively maturing females and juveniles in the harbours of the Sydney region (central New South Wales coast) suggests that the species may have bred successfully here. However, the relatively low numbers of A. flavimanus collected during the study indicate that as yet there has been no population explosion in New South Wales waters. A number of aspects of the biology and ecology of the species was examined in an attempt to identify features which may limit its distribution and abundance in the Sydney region.The inhibition of successful reproduction by the relatively warm-water temperatures in this area and the potential for competition with native fishes are proposed as possible explanations.
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    London : Periodicals Archive Online (PAO)
    Journal of adolescence. 8:1 (1985:Mar.) 33 
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  • 4
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    Unknown
    Provincetown, Mass., etc. : Periodicals Archive Online (PAO)
    Journal of General Psychology. 91 (1974:Oct.) 201 
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Children with non-alcoholic steatohepatitis are insulin-resistant and metformin has been proposed as a potential therapy. However, paediatric safety and efficacy data are absent.Aim : To test the hypothesis that metformin therapy will safely improve markers of liver disease in paediatric non-alcoholic steatohepatitis.Methods : Single-arm open-label pilot study of metformin 500 mg twice daily for 24 weeks in non-diabetic children with biopsy-proven non-alcoholic steatohepatitis.Results : Ten obese children (mean body mass index 30.4) enrolled and completed the trial. Mean alanine aminotransferase and aspartate aminotransferase (AST) improved significantly (P 〈 0.01) from baseline (184, 114 U/L) to end of treatment (98, 68 U/L). Alanine aminotransferase normalized in 40% and AST normalized in 50% of subjects. Children demonstrated significant improvements in liver fat measured by magnetic resonance spectroscopy (30–23%, P 〈 0.01); insulin sensitivity measured by quantitative insulin sensitivity check index (0.294–0.310, P 〈 0.05); and quality of life measured by pediatric quality of life inventory 4.0 (69–81, P 〈 0.01).Conclusion : Open-label treatment with metformin for 24 weeks was notable for improvement in liver chemistry, liver fat, insulin sensitivity and quality of life. A large randomized-controlled trial is needed to definitively determine the efficacy of metformin for paediatric non-alcoholic steatohepatitis.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 148 (2003), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 183 (1959), S. 99-100 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] MINERAL silicates have been directly implicated as fibrogenetic agents in certain of the pneumo-conioses (for example, asbestosis) and conceivably play a part in others. For example, Witwatersrand gold miners suffering from 'classical' silicosis have inhaled silicates in addition to quartz. If ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Accident Analysis and Prevention 3 (1971), S. 229-236 
    ISSN: 0001-4575
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Architecture, Civil Engineering, Surveying , Psychology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 28 (1988), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The anti-dinitro-phenyl (Dnp)IgM antibody response in mice was inhibited by administration of either a non-immunogenic form of Dnp-polyacrylamide (Dnp-Pa) or an excess amount of an immunogenic form of Dnp–Pa. Spleen cells, alive or heat-killed, from mice tolerized in vivo by either method, inhibited the anti-Dnp response of naive spleen cells co-cultured in vitro with antigen. Conversely, donor cells tolerized in vivo by a high dose of immunogenic Dnp–Pa, when titrated into a naive cell culture which contained no antigen, produced a stimulatory dose-response curve. Both the dose-dependent inhibition and stimulation correlated strongly with the amount of 125I-labelled Dnp–Pa carried over by tolerized spleen cells into the naive cell culture system. Because the doses and experimental procedures used were comparable to those commonly used for suppressor cell generation and assay, it is suggested that antigen-specific suppressor cells may produce their effects through passive transfer of antigen and/or tolerogen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 279 (1987), S. 257-265 
    ISSN: 1432-069X
    Keywords: Retinoid ; Keratinization ; Keratinocytes ; Cell culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A multilayered, continuously proliferating keratinocyte cell culture has been produced from rat sublingual epithelium. The rate of growth of the cultures was stable throughout long-term culture. Retinoic acid (3.3 μM) inhibited the keratinization of these cultures. Morphological changes included total loss of tonofilaments within 7 days, decrease in desmosomes, an increase in intercellular spaces, absence of thickened plasma membranes, and elongated and more numerous cytoplasmic projections. Exposure to retinoic acid (3.3 μM) for 33 days did not affect the growth rates of the cultures, as estimated from the protein and DNA content per flask. Retinoic acid (3.3 μM) reduced the polyacrylamide gel electrophoresis protein profile within 3 days of treatment and produced reductions in the incorporation of amino acids into keratins of molecular weights 62,000 and 60,000 within 24 h. All five keratin polypeptides showed a reduced incorporation rate after treatment for 3 days. This inhibition was reversible. Protein synthesis of nonkeratins was not detectably affected by retinoid treatment.
    Type of Medium: Electronic Resource
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