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A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis (1958)

KENDREW, J. C. ; BODO, G. ; DINTZIS, H. M. ; [et al.]

[s.l.] : Nature Publishing Group

Nature 181 (1958), S. 662-666

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] MYOGLOBIN is a typical globular protein, and is found in many animal cells. Like haemoglobin, it combines reversibly with molecular oxygen; but whereas the role of haemoglobin is to transport oxygen in the blood stream, that of myoglobin is to store it temporarily within the cells (a function ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/181662a0

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Tolerogen-Mediated Suppression of the Immune Response (1988)

DINTZIS, R. Z. ; MIDDLETON, M. H. ; DINTZIS, H. M.

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 28 (1988), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The anti-dinitro-phenyl (Dnp)IgM antibody response in mice was inhibited by administration of either a non-immunogenic form of Dnp-polyacrylamide (Dnp-Pa) or an excess amount of an immunogenic form of Dnp–Pa. Spleen cells, alive or heat-killed, from mice tolerized in vivo by either method, inhibited the anti-Dnp response of naive spleen cells co-cultured in vitro with antigen. Conversely, donor cells tolerized in vivo by a high dose of immunogenic Dnp–Pa, when titrated into a naive cell culture which contained no antigen, produced a stimulatory dose-response curve. Both the dose-dependent inhibition and stimulation correlated strongly with the amount of 125I-labelled Dnp–Pa carried over by tolerized spleen cells into the naive cell culture system. Because the doses and experimental procedures used were comparable to those commonly used for suppressor cell generation and assay, it is suggested that antigen-specific suppressor cells may produce their effects through passive transfer of antigen and/or tolerogen.