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  • 1
    Electronic Resource
    Electronic Resource
    Cutaneous mucinosis of infancy: is it a real entity or the paediatric form of lichen myxoedematosus (papular mucinosis)? (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We describe a girl presenting with a childhood dermal mucinosis in which we had the unique opportunity to find all the transitional histological features of lichen myxoedematosus (papular mucinosis), from its early focal mucin deposition in the reticular dermis to its late findings of interstitial mucin deposition, dermal fibrosis and fibroblast proliferation. Her father reported having had similar lesions when he was a child, which completely disappeared during adolescence. This case, and a re-evaluation of the literature, suggests that cases of cutaneous mucinosis of infancy that are not hamartomatous conditions such as mucinous naevi are in fact the infantile presentation of lichen myxoedematosus (papular mucinosis) and, in addition to other cases in the literature, suggests a genetic and familial factor in lichen myxoedematosus (papular mucinosis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04090.x
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  • 2
    Electronic Resource
    Electronic Resource
    Chlamydia trachomatis and male infertility: chlamydia-IgA antibodies in seminal plasma are C. trachomatis specific and associated with an inflammatory response (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 12 (1999), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is controversy over the role of asymptomatic genital tract infection by Chlamydia trachomatis, its optimal diagnosis, and its place in the etiology of male infertility.〈section xml:id="abs1-3"〉〈title type="main"〉ObjectiveComparision of direct detection of Chlamydia trachomatis in semen with the presence of chlamydia-antibodies in seminal plasma and serum, together with parameters of the spermatogram, in men of infertile relationships.〈section xml:id="abs1-4"〉〈title type="main"〉Study designProspective clinical study.〈section xml:id="abs1-5"〉〈title type="main"〉SettingUniversity hospital tertiary referral center.〈section xml:id="abs1-6"〉〈title type="main"〉Subjects and methodsTwo groups of consecutive andrological patients (n = 89 and n= 36) were investigated as follows: semen analysis, including concentration of granulocyte-elastase; detection of C. trachomatis in semen samples and first void urine by polymerase chain reaction (PCR) and antigen-ELISA (Celisa®); detection of chlamydia antibodies in serum and seminal plasma by recombinant antibody-enzyme-linked immunosorbent assay (rELISA®) and of Chlamydia trachomatis specific antibodies by the ImmunoComb®-Chlamydia-Bivalent test.〈section xml:id="abs1-7"〉〈title type="main"〉ResultsIn 2/125 (1.6%) semen samples Chlamydia trachomatis DNA was detected by PCR. Genus specific anti-chlamydia-IgA was found in 12/122 (9%) of the seminal plasmas. This IgA appeared to be specific for C. trachomatis. Seminal plasmas with chlamydia-IgA antibodies showed higher PMN-elastase levels than IgA negative samples (P 〈 0.04). Chla-mydia-IgG antibodies were present in 27/89 (30%) of the sera, but in only five of these 27 sera (19%) were the antibodies detected specific for C. trachomatis. There were no associations between any of these variables and the parameters of the routine semen analysis.〈section xml:id="abs1-8"〉〈title type="main"〉ConclusionIgA-chlamydial antibodies in seminal plasma appeared to be specific against C. trachomatis and were associated with an inflammatory response in the male genital tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1999.tb01005.x
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  • 3
    Electronic Resource
    Electronic Resource
    One - and two-dimensional EPR imaging in skin
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 9 (1990), S. 36 
    Details
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(90)90297-V
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  • 4
    Electronic Resource
    Electronic Resource
    Nitroxide radical biostability in skin
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 15 (1993), S. 415-423 
    Details
    ISSN: 0891-5849
    Keywords: Biostability ; Electron paramagnetic resonance ; Free radicals ; Nitroxides ; Reduction ; Skin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(93)90041-R
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  • 5
    Electronic Resource
    Electronic Resource
    Dihydrolipoate inhibits reactive oxygen species mediated skin inflammation
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 9 (1990), S. 189 
    Details
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(90)90849-E
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  • 6
    Electronic Resource
    Electronic Resource
    Kolonneoplasien und Hautfibrome: Gemeinsame Einflußgrößen und deren Bedeutung (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 83-88 
    Details
    ISSN: 1432-1440
    Keywords: Skin-tags ; Colonic-polyps ; Tubulovillous adenoma ; Colon carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To find common factors for colonic-neoplasias and skin-tags, 157 inpatients, who consecutively had a coloscopy because of intestinal complaints, were intensively examined dermatologically. Regression-analyses showed that the number of colonic polyps were age- (p=3×10−8) and sex-dependent (1.9×10−2) and skin-tags had no influence on the number of colonic polyps. The size of colonic polyps also showed a clear age dependency (p=3×10−8). The number of skin-tags were dependent on weight (p=9×10−3) and age (p=1.3×10−2), its size on the interaction of sex and triglyceride-levels (p=3×10−8). Discriminant-analyses identified the following factors as important: age and triglyceride-concentration to recognize a patient with colonic polyps; age, positive Haemoccult®-test and number of skin-tags to recognize a patient with tubulovillous adenomas or colonic carcinomas. The essential common factor of colonic polyps and skin-tags was the age. For the recognition of a patient with colonic polyps the age was the most essential factor, skin-tags, on the contrary, were unimportant. The association between colonic polyps and skin-tags therefore was merely an effect of age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646848
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  • 7
    Electronic Resource
    Electronic Resource
    Zur cytologischen Krebsvorsorge in einer venerologischen Untersuchungsstelle (1975)
    Springer
    Archives of gynecology and obstetrics 219 (1975), S. 58-59 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00668976
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  • 8
    Electronic Resource
    Electronic Resource
    On the interaction between anthralin and mitochondria: a revision (1986)
    Springer
    Archives of dermatological research 279 (1986), S. 59-65 
    Details
    ISSN: 1432-069X
    Keywords: Anthralin ; Mitochondria ; ATP ; Membrane inhibition of oxidative phosphorylation ; Electron spin resonance spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Anthralin is an inhibitor of oxidative phosphorylation at concentrations found in vivo. ADP-stimulated oxygen consumption is diminished. Consequently, the rate of ATP synthesis is reduced and mitochondrial ATP content declines. Neither the isolated ATPase (F1Fo-ATPase), nor the mitochondrial membrane-bound ATPase are influenced by the drug. Respiration under resting conditions is not affected. The experimental data unequivocally indicate that anthralin is not an uncoupler of oxidative phosphorylation, as previously stated. Furthermore, the interpretation that respiratory deficiency induced in yeast strains by anthralin is a consequence of petite mutations has to be reconsidered. Under in vivo conditions, anthralin inhibits respiration per se. Our experiments, including the electron spin resonance spectroscopy, reveal that anthralin alters mitochondrial membrane structure and function simultaneously. A redox or free-radical mediated step may be involved. In consequence, inhibition of ATP production occurs which may become the limiting factor for increased cellular metabolism in psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404360
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  • 9
    Electronic Resource
    Electronic Resource
    Multifunctional analysis of the interaction of anthralin and its metabolites anthraquinone and anthralin dimer with the inner mitochondrial membrane (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 47-55 
    Details
    ISSN: 1432-069X
    Keywords: Anthralin ; Anthraquinone ; Anthralin dimer ; Mitochondria ; Oxidation reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We studied the interaction of the antipsoriatic compound anthralin (1.8-dihydroxy-9-anthrone), and its metabolites anthraquinone (1.8-dihydroxy-9.10-anthraquinone) and anthralin dimer (1.8.1′.8′.-tetrahydroxy-10.10′-bis-9[10]-dianthrone) with the inner mitochondrial membrane. Mitochondrial membrane functions such as ubiquinone redox equilibria, redox status of iron sulfur clusters, cyanide-sensitive and cyanide-insensitive oxygen consumption, adenosine triphosphate (ATP) synthesis, ATP hydrolysis, and adenine nucleotide content of mitochondria were analyzed. Anthralin is an inhibitor of mitochondrial oxygen uptake in the presence of ADP and substrate (cyanide-sensitive respiration), inhibits ATP synthesis without affecting ATP hydrolysis, and depletes mitochondria of ATP. Anthralin dimer is a much weaker inhibitor of mitochondrial functions and anthraquinone is almost inactive. Anthralin, but not anthraquinone and anthralin dimer, reverses uncoupler stimulated oxygen consumption, stimulates cyanide-insensitive respiration, reduces mitochondrial ubiquinone-9 and -10 to the corresponding ubiquinols and reduces mitochondrial iron sulfur clusters. Anthralin may induce formation of reactive oxygen species by enhancing autoxidation of mitochondrial components and/or by catalyzed oxidation of anthralin. Taken together, anthralin acts as an electron donor to inner mitochondrial membrane associated redox components, inhibits the electron transport chain, and has an oligomycin-like effect. Anthralin dimer and anthraquinone do not function as electron donors and act by a different reaction mechanism. Respiratory measurements in human keratinocytes revealed similar results as obtained with isolated mitochondria. We suggest that modulation of membrane redox status may be a common concept of anthralin action in target cells such as keratinocytes and neutrophils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505645
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  • 10
    Electronic Resource
    Electronic Resource
    Vitiligo-Therapie mit Phenylalanin/UV A (1994)
    Springer
    Der Hautarzt 45 (1994), S. 460-463 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Vitiligo – Phenylalanin-UVA – Therapiestudie ; Key words: Vitiligo – Phenylalanine-UVA – Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary. Since 1983 the administration of phenylalanine combined with UVA exposure (PAUVA) has been a well-known therapy for vitiligo. We have found no retrospective studies on this therapy. To document the long-term results and side effects, we performed a retrospective study on 41 patients who had received PAUVA therapy about 5 years ago. Examination was possible in 25 of the 41 patients, and 11 of them (44%) had permanent repigmentation. Depigmentation either during or after PAUVA therapy was recognized in 16 of the 25 patients (64%). In 52% of cases the patients were satisfied with the therapy and would repeat it; 68% would recommend it. Positive features in prognosis, i.e. indicative of good repigmentation, were vitiligo extending over less than 25% of the body surface, onset of vitiligo before the age of 21, generalized and symmetrical distribution and a long duration of UV therapy. None of our patients developed long-term side effects. PAUVA therapy is demonstrably a therapeutic alternative for certain patients.
    Notes: Zusammenfassung. Seit 1983 wird zur Behandlung der Vitiligo Phenylalanin in Kombination mit UV-A-Bestrahlung (PAUVA) vermehrt eingesetzt. Langzeitergebnisse liegen bisher nicht vor. Um den Langzeitverlauf und die Langzeitnebenwirkungen zu erfassen, wurden 41 Patienten 5 Jahre nach PAUVA-Therapie angeschrieben. 25/41 konnten nachuntersucht werden. 11/25 (44%) zeigten einen anhaltenden Therapieerfolg. Eine Depigmentierung sowohl während als auch nach Therapieende trat bei 16/25 (64%) auf. 52% waren subjektiv zufrieden und würden die Therapie wiederholen, 68% würden diese weiterempfehlen. Als prognostisch günstige Parameter für ein gutes Ansprechen auf die Therapie konnten ein Befall der Körperoberfläche 〈25%, ein Vitiligobeginn vor dem 21. Lebensjahr, eine generalisierte stammbetonte Verteilung und UV-Bestrahlungen über längere Zeiträume angesehen werden. Langzeitnebenwirkungen wurden nicht festgestellt. Die PAUVA-Therapie kann demnach für bestimmte Patienten eine hilfreiche therapeutische Alternative darstellen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050104
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