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  • 1
    Electronic Resource
    Electronic Resource
    A new immunoperoxidase assay for Lolium perenne-specltic IgE in serum based on the biotin/avidin system (BAS) (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new solid-phase immunoassay based on the biotin/avidin system (BAS) for measuring scrum Lolium perenne (LP)-specific IgE antibody is described. LP-specific IgE was assayed by the BAS assay and RAST for comparison in the sera of thirty-two normal asymptomatic subjects R AST-negative for LP and of twenty-six subjects with hay fever and R AST-positive for LP. The specificity of the BAS assay for LP-specific IgE was demonstrated by absorption experiments. An overall agreement of 91% (53/58) was observed between the BAS and RAST and a high correlation (r= 0.87. P 〈 0.001) was found between the LP-specific IgE determined by the two methods. The advantages of ihe BAS assay as compared to both the RAST and classical ELISA arc discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1984.tb02218.x
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  • 2
    Electronic Resource
    Electronic Resource
    Different role of secretory IgA in the pathogenesis of RAST-positive and RAST-negative atopic dermatitis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 12 (1982), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Secretory-IgA (SIgA) concentrations were determined in whole saliva, unstimulated or stimulated by lemon juice, of thirty-eight children with atopic dermatitis, which comprised three adolescents, sixteen with IgE detected by RAST to one or more common allergen and twenty-two without specific IgE by RAST. There were thirty healthy controls matched for age and sex.The mean amount of total IgE was significantly greater in the RAST-positive than in the RAST-negative group. The mean SIgA concentration in unstimulated saliva of the RAST-positive atopic dermatitis group was less than that of the RAST-negative atopic dermatitis group and control groups, though the mean concentrations of SIgA of stimulated saliva were not significantly different in the three groups. It is suggested that the pathogenesis of atopic dermatitis may differ in children with or without specific-IgE antibodies; in those who were RAST-positive deficient exclusion of allergen by the intestinal barrier contributed to the pathogenesis, but not in those who were RAST-negative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1982.tb02545.x
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  • 3
    Electronic Resource
    Electronic Resource
    Selective IgA deficiency: Clinical and immunological evaluation of 50 pediatric patients (1980)
    Springer
    European journal of pediatrics 133 (1980), S. 101-106 
    Details
    ISSN: 1432-1076
    Keywords: IgA deficiency ; Atopy ; Infection ; Chromosome defects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fifty children with IgA deficiency were followed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (〈2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telangiectasia, were not included. Most children with complete deficiency of IgA had recurrent respiratory and/or gastrointestinal infections, about half with onset in the first year of life, while partial deficiency of IgA has probably little if any importance for anti-infectious immunity but is important in the pathogenesis of atopy. Atopic diseases were frequent in both groups. Chromosomal abnormalities were found in 2 patients: trisomy 21 in one and in the other a ring chromosome 18. No important defects in cellular immunity were detected but some isolated, borderline abnormalities were often present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441577
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  • 4
    Electronic Resource
    Electronic Resource
    Screening for delayed-hypersensitivity in Italian children: Multicentric study by multitest skin testing (1990)
    Springer
    European journal of pediatrics 150 (1990), S. 37-39 
    Details
    ISSN: 1432-1076
    Keywords: Delayed hypersensitivity ; Skin testing ; Cell-mediated immunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Multitest skin test allows the simultaneous intradermal application of seven standardized recall antigens in a reproducible manner. Response reading is based on a scoring system that distinguishes between normal and diminished delayed hypersensitivity (DH). To determine incidence and size of DH responses for each antigen in relation to age and sex in healthy Italian children, a multicentric study was performed on a representative paediatric population of 491 subjects (285 males and 296 females) aged from 4 months to 16 years. In both sexes DH reactivity as measured by score and number of positive responses increased significantly with age. The incidence of anergy was 8.8% for the whole population and decreased significantly with age in both sexes. Incidence of positive responses was highest for tetanus and diphteria toxoids, intermediate forCandida, Proteus andStreptococcus, and lowest for tuberculin andTrichophyton antigens. There was no significant difference between sexes in the incidence of positive response to each antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959477
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  • 5
    Electronic Resource
    Electronic Resource
    Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts (1989)
    Springer
    European journal of pediatrics 149 (1989), S. 164-167 
    Details
    ISSN: 1432-1076
    Keywords: IgG subclasses ; Immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract IgG subclass levels were determined in 448 normal children from 6 months to 18 years of age and in 141 healthy adults by radial immunodiffusion using monoclonal antibodies. Age-normal percentile values were calculated for each year of age up to 18 years for IgG1, IgG2, IgG3 and in adults for all four subclasses. The broad spread of IgG4 values in children did not permit calculation of reference values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958271
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  • 6
    Electronic Resource
    Electronic Resource
    Immunodeficiency in Down's syndrome: Relationship between presence of human thyroglobulin antibodies and HBsAg carrier status (1977)
    Springer
    European journal of pediatrics 126 (1977), S. 139-146 
    Details
    ISSN: 1432-1076
    Keywords: Down's syndrome ; Immunodeficiency ; HBsAg ; Thyroglobulin antibodies ; Autoimmunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between the presence of hepatitis B surface antigen (HBsAg) and antibodies to human thyroglobulin (HTgAb) has been studied in 110 subjects with Down's syndrome (DS) from 4 months to 50 years of age and in 122 controls carefully matched for sex, age and socio-environmental conditions. The overall percentage of HBsAg carriers was 22.7 in DS and 6.6 in controls and that of HTgAb-positive subjects was 41.8 in DS and 19.7 in controls. In DS the frequency of HTgAb-positive subjects was very high, even in the youngest age groups in which the percentage of HBsAg carriers was relatively low; the latter thereafter showed a marked increase with age. A positive association between the presence of HBsAg and HTgAb was found only in the oldest age group of DS subjects. It is thus concluded that in DS the high frequency of HTgAb cannot be attributed to chronic hepatitis B virus infection. On the contrary, the presence of HTgAb might well represent an early “marker” of immunodeficiency and increased susceptibility to infection with hepatitis B virus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442195
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  • 7
    Electronic Resource
    Electronic Resource
    Pulmonary hypertrophic osteoarthropathy in a child with late-onset agammaglobulinemia (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 199-201 
    Details
    ISSN: 1432-1076
    Keywords: Pulmonary hypertrophic osteoarthropathy ; agammaglobulinemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of hypertrophic osteoarthropathy is described in an 8-year-old child with late-onset agammaglobulinemia, bronchiectasis and clubbing of the fingers and toes. The child presented with pain of recent onset in the legs, ankles, and knees and a diagnosis of hypertrophic osteoarthropathy was made on the basis of the radiologic findings. Therefore the differential diagnosis of bone and joint pain in agammaglobulinemic subjects must take into account hypertrophic osteoarthropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01377357
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  • 8
    Electronic Resource
    Electronic Resource
    Radiographic findings in hereditary multiple exostoses and a new theory of the pathogenesis of exostoses (1990)
    Springer
    Pediatric radiology 20 (1990), S. 594-597 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Analysis of 330 exostoses in 18 patients affected by hereditary multiple exostoses disease suggested a new classification of exostoses as eccentric or full-thickness. Radiographically arrest of metaphyseal remodeling with failure of coning and persistence of the primary metaphyseal trabeculae was evident in full-thickness exostoses. Similar bone lesions can be obtained experimentally with inhibitors of bone turn-over. A localized, peripheral defect in remodeling over a limited time can give a satisfactory explanation also for the origin of eccentric exostoses. The thesis that this is the basic mechanism of exostosis formation is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02129063
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  • 9
    Electronic Resource
    Electronic Resource
    Infectious mononucleosis fifty years after the discovery of the Paul-Bunnell test (1983)
    Springer
    Infection 11 (1983), S. 1-5 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Paul-Bunnell-Test ist nun 50 Jahre alt; trotz der Entwicklung verschiedener klinisch anwendbarer immunologischer Nachweisverfahren für Bestandteile des Epstein-Barr-Virus (EBV) ist er immer noch grundlegend wichtig für die Diagnose der infektiösen Mononukleose. Der Nachweis von Agglutininen gegen Schaferythrozyten bei der infektiösen Mononukleose (Paul-Bunnell) stellt im Grunde zugleich die erste Beobachtung von heterophilen Antikörpern bei dieser Viruskrankheit dar. Mehrere Jahrzehnte sind danach verstrichen, bis nachgewiesen wurde, daß die infektiöse Mononukleose eine polyklonale Antikörperbildung hervorruft, die auch gegen ein breites Spektrum von Autoantigenen gerichtet ist. Der selektive Tropismus des EBV für B-Lymphozyten und die Reaktionen der T-Lymphozyten gegen die infizierten B-Lymphozyten sind Ursache für diese massive Antikörperantwort und die charakteristischen pathophysiologischen Elemente der infektiösen Mononukleose.
    Notes: Summary The Paul-Bunnell test, now 50 years old, is still of fundamental importance in the diagnosis of infectious mononucleosis, even though various immunologic methods have been developed in clinical practice to identify constituents of the Epstein-Barr virus (EBV). The demonstration of sheep red cell agglutinins in infectious mononucleosis (Paul-Bunnell) was in fact the first observation of the presence of heterophil antibodies in this viral disease which was later shown to evoke a polyclonal antibody response to a wide spectrum of autoantigens as well. The selective tropism of EBV for B lymphocytes and the reactivity of T lymphocytes to these infected B lymphocytes are the pathophysiological elements characteristic of infectious mononucleosis, and are the reason for this massive antibody response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01651349
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  • 10
    Electronic Resource
    Electronic Resource
    Rapidly reversible depression of delayed hypersensitivity in two children with visceral leishmaniasis (1975)
    Springer
    Infection 3 (1975), S. 231-233 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es werden zwei Fälle viszeraler Leishmaniase bei Kindern beschrieben. In beiden Fällen war in vitro die Lymphozytenreaktion auf mitogene Substanz und allogene Zellen anfangs deutlich gehemmt, kehrte aber nach sechstägiger Behandlung mit N-methyl-glucamin-antimonat innerhalb einiger Tage zur Norm zurück. In einem Fall kehrte sich nach der Behandlung der Candidin-Hauttest von negativ nach positiv um und im zweiten Fall fand sich ein zirkulierender Serumfaktor, der die Phytohämagglutinin-sowie die gemischte Reaktivität normaler Lymphozyten stark hemmte, jedoch nach der Therapie verschwand.
    Notes: Summary Two cases of visceral leishmaniasis in children are described. In both “in vitro” lymphocyte response to mitogens and allogeneic cells was initially markedly depressed, but returned to normal within a few days after six days of treatment with N-methylglucamine antimonate; in one the candidin skin test reverted from negative to positive after treatment and in the other a circulating serum factor was found which strongly inhibited phytohemagglutinin — and mixed — responsiveness of normal lymphocytes, but disappeared after therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01642772
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