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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of interventional cardiology 10 (1997), S. 0 
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 70 (1992), S. 1024-1026 
    ISSN: 1432-1440
    Keywords: Left main coronary artery stenosis ; Non-Hodgkin lymphoma ; Cardiac metastases ; Azathioprine side effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 50-year-old patient presented with a 3-month history of chest pain, a pathological result on electrocardiogram stress test, and signs of coronary heart disease on myocardial scintigraphy. Coronary angiography showed an isolated, moderate tubular stenosis of the left main coronary artery. Coronary bypass surgery was carried out, and intraoperative examination revealed a mediastinal lymphoma which caused the stenosis of the left main artery by external compression.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1440
    Keywords: Coronary angioplasty ; Excercise ; Atrial natriuretic factor ; Pulmonary artery pressure ; Right atrial pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary According to several reports of close correlations between pulmonary artery pressure and ANF plasma levels it would be convenient to replace invasive pressure monitoring by ANF determination. Mean pulmonary artery and right atrial pressures and pulmonary artery as well as peripheral venous ANF plasma concentrations were measured in 24 patients before and after coronary angioplasty (PTCA) continuously at rest and during exercise: At rest, both pressure and ANF-values remained unchanged before and after PTCA. At exercise, there was a decrease of mean pulmonary artery pressure (from 41.3±8.6 to 31.5±7.4 mmHg,p〈0.001), mean right atrial pressure (from 11.9±3.0 to 9.0±2.3 mmHg,p〈 0.001), pulmonary artery (282.5±191.0 to 207.3±157.2 pg/ml,p〈0.05) and peripheral venous (112.7±48.0 to 97.1±53.2 pg/ml, n.s.) ANF concentration after PTCA. We found no correlation between PTCA-induced changes of right arterial pressures and ANF concentrations, while changes of pulmonary artery pressures were significantly correlated to changes of peripheral venous (r=0.79,p〈0.001) as well as pulmonary artery (r=0.59,p〈0.01) ANF concentrations at exercise. In 6 of the 24 patients, however there was an inverse relationship between changes of pulmonary artery pressures and ANF concentrations. — Our data demonstrate a significant correlation between changes of ANF plasma level and pulmonary artery pressure values at exercise after PTCA. In the individual case however invasive pressure monitoring cannot be replaced by determination of ANF plasma levels.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 263 (1969), S. 185-185 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 64 (1986), S. 587-589 
    ISSN: 1432-1440
    Keywords: Kidney ; Fibrinolysis ; Renal veins ; Acute renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 50 patients without renal insufficiency, fibrinolytic activity, as reflected by euglobulin lysis time, was determined in blood obtained from the renal veins, the renal artery and a peripheral vein. Fibrinolytic activity was found to be significantly higher in the renal veins than in the renal artery and the peripheral vein. Other coagulation and fibrinolysis parameters did not show such differences. In addition, a patient with acute oligoanuric renal failure was investigated. This patient demonstrated reduced overall fibrinolytic activity, but there were no differences between the activity in the blood of the renal veins and that of the renal artery or peripheral vein. It seems, therefore, that the kidneys release plasminogen activators into the systemic circulation. This may be decreased in renal failure, probably contributing to the well-known diminished fibrinolysis in some kidney diseases.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 35 (1988), S. 305-308 
    ISSN: 1432-1041
    Keywords: urapidil ; left ventricular failure ; haemodynamic parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Urapidil, a new alpha1-adrenoceptor blocking drug, has been shown to be effective in the treatment of hypertension. Ten normotensive patients with severe congestive heart failure were given Urapidil 25 mg i.v. twice in 15 min and the haemodynamic effects were measured. There was a significant fall in systolic blood pressure (−16%), mean blood pressure (−13%), left ventricular end-diastolic pressure (−38%), mean pulmonary artery pressure (−31%) and wedge pressure (−40%). Total peripheral resistance fell by 25%, whereas pulmonary arteriolar resistance did not change significantly. Cardiac output increased by 22%. The increase in cardiac output with decreasing peripheral resistance and LV pressures suggests that urapidil may be useful in the therapy of congestive heart failure.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1440
    Keywords: Cineventriculography ; left ventricular function ; coronary heart disease ; mean velocity of circumferential fiber shortening ; left ventricular wall thickness ; Cineventrikulographie ; linksventriculäre Funktion ; Coronare Herzerkrankung ; mean velocity of circumferential fibershortening ; Wanddicke des linken Ventrikels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aus den Cineventrikulogrammen von 12 Herzgesunden und 24 Patienten mit coronarer Herzerkrankung wurde in jeweils drei Ventrikelabschnitten die Geschwindigkeit bestimmt, mit der sich die Circumferenz verkürzt (VCF). Zusätzlich wurde in den gleichen Abschnitten die Wanddicke gemessen. Bei den 12 Herzgesunden beträgt VCF in den einzelnen Abschnitten, bezeichnet B, D und A 1,26±0,5 circ/sec, 1,25±0,07 circ/sec und 1,26±0,07 circ/sec. In den zugeordneten Wandbezirken nahm die Wanddicke um 47,4±14,3%, 42,6±7,5% und 44,2±7,9% zu. Bei den 24 Patienten mit coronarer Herzerkrankung war VCF in allen Abschnitten deutlich vermindert und zudem in den einzelnen Abschnitten untereinander verschieden. Die Ergebnisse zeigen, daß beim normalen linken Ventrikel die Verkürzung in den drei Abschnitten nahezu gleichmäßig und gleichschnell erfolgt und die Wanddicke um annähernd den gleichen Betrag zunimmt. Der Mittelwert der drei Verkürzungsgeschwindigkeiten eines Ventrikels, bezeichnet als VCFmittelBDA, stellt einen guten Index für die ventriculäre Gesamtfunktion dar. Wird die Differenz aus der maximalen und der minimalen Verkürzungsgeschwindigkeit durch die maximale Verkürzungsgeschwindigkeit dividiert, so ergibt sich ein Quotient (Δmax/VCFmax), mit dem sich lokale Funktionsstörungen sicher erkennen lassen. An Hand des Quotienten ist eine ausgezeichnete Trennung zwischen normalen Ventrikeln und solchen mit coronaren Gefäßveränderungen möglich. Bei 95% der Patienten mit coronarer Herzerkrankung ließen sich lokale Störungen der Myokardfunktion nachweisen.
    Notes: Summary The cineventriculograms were examined in 12 healthy subjects and 24 patients with coronary heart disease. In each ventricle the mean velocity of circumferential fiber shortening was determined for three different regions (B, D and A). In addition, the increase in left ventricular wall thickness was measured. In the 12 normal left ventricles the mean velocity of circumferential fiber shortening (VCF) averaged 1.26±0.05 circ/sec in region B, 1.25±0.07 in D and 1.26±0.07 circ/sec in A respectively. There was an average increase in wall thickness of 47.4±14.3% in region B, of 42.6±7.5% in D and of 44.2±7.9% in A, respectively. In the 24 ventricles with coronary artery disease VCF was clearly diminished in all regions and averaged 0.85±0.06 circ/sec in B, 0.68±0.08 in D and 0.66±0.06 circ/sec in A. The results indicate that fibers shortening in the normal left ventricle occurs in the three regions nearly uniformly and at the same speed. In ventricles with coronary artery disease, however, VCF is decreased and shows marked differences between the three regions. By averaging VCF of the 3 regions for each ventricle, total left ventricular function can be determined. Local disturbances in left ventricular function can be recognized by dividing the difference between maximal and minimal VCF by the maximal VCF. The index is called Δmax/VCFmax and allows to separate normal left ventricles from those with coronary artery disease. Local disorders in left ventricular function could be demonstrated using the index in 95% of the patients with coronary heart disease.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-1285
    Keywords: Schlüsselwörter PTCA –¶linker Hauptstamm –¶Angioplastie ; Key words PTCA –¶left main coronary artery –¶angioplasty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In cases with protected left main stenosis by previous bypass surgery or as an emergency intervention in patients presenting with acute myocardial infarction and cardiogenic shock, percutaneous transluminal coronary angioplasty is performed as an alternative treatment strategy to bypass surgery. A review of 262 left main angioplasties revealed a procedure-related mortality in cases without protection of the left main coronary artery of 9.1% (4/44), in cases with partially protected left main stenosis by collaterals to either left coronary artery of 4.8% (1/21) and 0.5% (1/187) in cases with nonobstructed bypass grafts to either left coronary artery. Coronary angioplasty of an unprotected left main coronary artery, had an unacceptably high procedure-related mortality rate and should therefore not be performed even in cases of emergency intervention. The risk stratification of the procedure can be evaluated by the proposed grading of left main artery protection.
    Notes: Zusammenfassung Die Behandlung hochgradiger symptomatischer Hauptstammstenosen der linken Koronararterie ist die operative Revaskularisation. Bei geschütztem Hauptstamm durch vorangegangene Bypass-Operation oder als Notfall-Eingriff im akuten Myokardinfarkt mit kardiogenem Schock wird die perkutane transluminale Angioplastie als Behandlungsalternative durchgeführt. Die Durchsicht von 262 Interventionen ergab eine Mortalität der Intervention von 9,1% ¶(4/44) bei Patienten ohne Hauptstamm-Protektion, 4,8% (1/21) bei Patienten mit Kollateralen und 0,5% (1/197) bei Patienten mit offenem Bypass-Gefäß zu einem der Gefäße der linken Koronararterie. Die koronare Agioplastie des ungeschützten Hauptstamms hat ein nicht akzeptables Risiko und sollte daher auch als Notfall-Eingriff nicht durchgeführt werden. Das Risiko der Hauptstamm-PTCA kann durch die vorgeschlagene Einteilung der Hauptstamm-Protektion durchgeführt werden.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 364 (1984), S. 472-472 
    ISSN: 1435-2451
    Keywords: Coronary revascularization ; Bypass stenosis ; Bypass occlusion ; Angina pectoris ; Coronarrevascularisation ; Bypassverschluß ; Reoperation ; Angina pectoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Angina pectoris-Beschwerden und EKG-Veränderungen stellen die Indikation zur Re-Angiographie nach Coronar-Bypassoperation dar. Ursachen sind: 1. Bypasstenose oder Bypassverschluß, 2. inkomplette Revascularisation, 3. Fortschreiten der KHK, 3. Kombinationen. Reoperationsrate in der Literatur 1,2-3,5%, Göttingen 1% (21/2067 Patienten). Diffus arteriosklerotisch veränderte Coronargefäße mit schlechtem Run-off limitieren die Indikation zur Reoperation. Das Risiko für den Zweiteingriff wird beeinflußt von Verwachsungen und intra- bzw. postoperativen Blutungen, die Operationsletalität ist in unserem Krankengut nicht wesentlich höher.
    Notes: Summary After coronary artery bypass surgery, reangiography is indicated by angina pectoris and changes in the ECG. The causes are: (1) bypass stenosis or occlusion, (2) incomplete revascularization, (3) progressive coronary artery sclerosis, and (4) combinations of these conditions. The rate of reoperation is between 1.2% and 3.5%; in Göttingen it is 1% (21/2,067 patients). The indication for reoperation is limited by diffuse atherosclerosis of coronary artery vessels with poor run-off. The risk of coronary reoperation depends on adhesions and intra- or postoperative bleeding and is no higher than for the first operation. For bypass stenosis, balloon dilatation is a useful alternative.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Am Modellkreislauf wurde in 89 Einzelmessungen bei kontinuierlicher und pulsierender Strömung die Beziehung zwischen videodensitometrisch mittels Frontgeschwindigkeit bestimmtem und elektromagnetisch ermitteltem Fluß untersucht. Der Rohrdurchmesser der videodensitometrischen Meßstrecke lag zwischen 0,305 cm und 0,518 cm. Zwischen den Flußgeschwindigkeiten bestand bis zu einer Reynold-Zahl von Re=225 ein linearer Zusammenhang. Dabei wurde der wahre (elektromagnetische Messung) Fluß bei kontinuierlicher Strömung um 21% (r=0,99; Syx=±14.5 ml/min) und bei pulsierender Strömung um 24% (r=0,98; Syx=±20.8 ml/min) überschätzt. Danach ist unter Berücksichtigung der Überschätzung eine videodensitometrische Bestimmung des phasischen und mittleren Flusses zuverlässig möglich.
    Notes: Summary The relation between videodensitometrically measured front velocity and electromagnetically assessed flow was examined in a circulatory model with continuous as well as pulsatile flow (89 experiments). The diameter of the tubes in the videodensitometric measuring section was 0.305 to 0.518 cm. A linear correlation was proved in flow velocities up to Reynold's number Re=225. The exact flow, measured electromagnetically, was overestimated in continuous flow by 21% (r=0.99, Syx=±14.5 ml/min) and in pulsatile flow by 24% (r=0.98, Syx=±20.8 ml/min). In view of these results the phasic and average flow can be calculated acurately using videodensitometric techniques.
    Type of Medium: Electronic Resource
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