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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 8 (1992), S. 774-781 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 247-248 
    ISSN: 1432-1440
    Keywords: Myoglobin ; Renal failure ; Myocardial infarction ; Myoglobin ; Niereninsuffizienz ; Myokardinfarkt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 44 Patienten mit chronischer Niereninsuffizienz unterschiedlicher Äthiologie wurde das immunreaktive Serum-Myoglobin bestimmt und mit den Werten von Probanden mit normaler Nierenfunktion verglichen. Es fand sich — unabhängig von der Grunderkrankung — eine hoch signifikante lineare Korrelation zwischen dem Serum-Myoglobin und der Serum-Kreatinin-Konzentration. Bei Patienten mit Serum-Kreatinin-Werten über 550 µMol/1 (6,2 mg-%) lagen die Serum-Myoglobin Konzentrationen fast regelmäßig im pathologischen Bereich. Dies gilt auch für chronische Dialysepatienten. Die Befunde zeigen, daß bei Patienten mit höhergradiger, chronischer Niereninsuffizienz das Serum-Myoglobin nur mit Einschränkung zur Infarktdiagnostik geeignet ist.
    Notes: Summary In 44 patients with chronic renal failure of varied etiology serum immunoreactive myoglobin was measured and compared to values obtained in patients with normal renal function. Irrespective of the underlying disease a highly significant linear correlation was found between serum immunoreactive myoglobin and serum creatinine concentration. In patients with serum creatinine concentrations above 550 µmol/1 (6.2 mg%) serum myoglobin was as a rule elevated above the range found in the controls with normal renal function. This was also true in dialysis patients. These result demonstrate that serum myoglobin may only be used with restrictions in the diagnosis of myocardial infarction in patients suffering from advanced chronic renal failure.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: Amiodarone ; Reverse T3 ; Antiarrhythmic efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-eight patients with refractory supraventricular and ventricular tachyarrhythmias were administered a mean oral dosage of 400 mg amiodarone daily (200–600 mg). A high-pressure liquid chromatography method was used to measure serum concentrations of amiodarone and its metabolite desethylamiodarone after one week, one month, three months, and then at 6-month intervals. In 24 patients subcutaneous fatty tissue concentrations were also measured. The mean follow-up was 9 months (4 days to 29 months). A linear correlation was found between amiodarone and its metabolite in serum (r=0.56,p〈0.001) as well as in subcutaneous fatty tissue (r=0.67,p〈0.001). While serum concentrations were dose dependent, tissue concentrations accumulated during chronic therapy (p〈0.01, both). Clinical efficacy was achieved in 84% of the patients. No statistically significant difference was found between responders and non-responders as regards serum and subcutaneous fatty tissue concentrations. Side effects of amiodarone occurred in 63%. The incidence of adverse effects was related to significantly higher serum and subcutaneous fatty tissue concentrations of amiodarone and its metablite (p〈0.001, both). Thus, although the determination of serum and subcutaneous fatty tissue concentrations does not seem to be helpful for assessing clinical efficacy of this antiarrhythmic drug, these values may predict the occurrence of adverse effects.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1440
    Keywords: Cineventriculography ; left ventricular function ; coronary heart disease ; mean velocity of circumferential fiber shortening ; left ventricular wall thickness ; Cineventrikulographie ; linksventriculäre Funktion ; Coronare Herzerkrankung ; mean velocity of circumferential fibershortening ; Wanddicke des linken Ventrikels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aus den Cineventrikulogrammen von 12 Herzgesunden und 24 Patienten mit coronarer Herzerkrankung wurde in jeweils drei Ventrikelabschnitten die Geschwindigkeit bestimmt, mit der sich die Circumferenz verkürzt (VCF). Zusätzlich wurde in den gleichen Abschnitten die Wanddicke gemessen. Bei den 12 Herzgesunden beträgt VCF in den einzelnen Abschnitten, bezeichnet B, D und A 1,26±0,5 circ/sec, 1,25±0,07 circ/sec und 1,26±0,07 circ/sec. In den zugeordneten Wandbezirken nahm die Wanddicke um 47,4±14,3%, 42,6±7,5% und 44,2±7,9% zu. Bei den 24 Patienten mit coronarer Herzerkrankung war VCF in allen Abschnitten deutlich vermindert und zudem in den einzelnen Abschnitten untereinander verschieden. Die Ergebnisse zeigen, daß beim normalen linken Ventrikel die Verkürzung in den drei Abschnitten nahezu gleichmäßig und gleichschnell erfolgt und die Wanddicke um annähernd den gleichen Betrag zunimmt. Der Mittelwert der drei Verkürzungsgeschwindigkeiten eines Ventrikels, bezeichnet als VCFmittelBDA, stellt einen guten Index für die ventriculäre Gesamtfunktion dar. Wird die Differenz aus der maximalen und der minimalen Verkürzungsgeschwindigkeit durch die maximale Verkürzungsgeschwindigkeit dividiert, so ergibt sich ein Quotient (Δmax/VCFmax), mit dem sich lokale Funktionsstörungen sicher erkennen lassen. An Hand des Quotienten ist eine ausgezeichnete Trennung zwischen normalen Ventrikeln und solchen mit coronaren Gefäßveränderungen möglich. Bei 95% der Patienten mit coronarer Herzerkrankung ließen sich lokale Störungen der Myokardfunktion nachweisen.
    Notes: Summary The cineventriculograms were examined in 12 healthy subjects and 24 patients with coronary heart disease. In each ventricle the mean velocity of circumferential fiber shortening was determined for three different regions (B, D and A). In addition, the increase in left ventricular wall thickness was measured. In the 12 normal left ventricles the mean velocity of circumferential fiber shortening (VCF) averaged 1.26±0.05 circ/sec in region B, 1.25±0.07 in D and 1.26±0.07 circ/sec in A respectively. There was an average increase in wall thickness of 47.4±14.3% in region B, of 42.6±7.5% in D and of 44.2±7.9% in A, respectively. In the 24 ventricles with coronary artery disease VCF was clearly diminished in all regions and averaged 0.85±0.06 circ/sec in B, 0.68±0.08 in D and 0.66±0.06 circ/sec in A. The results indicate that fibers shortening in the normal left ventricle occurs in the three regions nearly uniformly and at the same speed. In ventricles with coronary artery disease, however, VCF is decreased and shows marked differences between the three regions. By averaging VCF of the 3 regions for each ventricle, total left ventricular function can be determined. Local disturbances in left ventricular function can be recognized by dividing the difference between maximal and minimal VCF by the maximal VCF. The index is called Δmax/VCFmax and allows to separate normal left ventricles from those with coronary artery disease. Local disorders in left ventricular function could be demonstrated using the index in 95% of the patients with coronary heart disease.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 65 (1987), S. 424-427 
    ISSN: 1432-1440
    Keywords: Valproate intoxication ; Cerebral edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 29-year-old man, who had been treated with sodium valproate for 3 years because of generalized cerebral seizures, ingested a large amount of this drug in an attempt to suicide. The exact amount he had swallowed could not be determined. The patient arrived in the intensive care unit in a deep coma, was intubated, and artificially ventilated. He developed a massive cerebral edema, as proved by computerized tomography (CT). This was supported by electroencephalography (EEG). The measured value for the concentration of valproate in serum was markedly elevated on the day of admission (2300 µmol/l; therapeutic range 350–700 µmol/l). Treatment with sodium thiopental, glycerol, and glucocorticoids was initiated. A second CT scan performed 9 days after admission showed a complete normalization and the EEG yielded a markedly improved pattern. At this point the patient slowly regained consciousness. We conclude that in patients with an acute sodium-valproate intoxication, care should be taken with regard to the development of a severe cerebral edema, which in the reported case could be treated successfully.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 66 (1988), S. 639-642 
    ISSN: 1432-1440
    Keywords: Acenocoumarol ; Coumarins ; Leukocytes ; Leukocytosis ; Side effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A male patient had been treated with acenocoumarol for 9 years. Raised white cell count returned to normal, when acenocoumarol was substituted by heparin, but rose again after reexposure. An analysis of variance showed that this effect is mediated by neutrophils only. The rise is quick and may therefore be caused by a redistribution of white cells rather than by increased cell production.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 57 (1979), S. 225-235 
    ISSN: 1432-1440
    Keywords: Angina pectoris ; Diagnostic criteria ; Myocardial infarction ; Serum myoglobin ; Radioimmunoassay ; Angina pectoris ; Diagnostik ; Myokardinfarkt ; Radioimmunoassay ; Serum-Myoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Radioimmunoassay zur Bestimmung von Serum-Myoglobin (SMb) wird vorgestellt. Bei 50 gesunden Probanden beträgt der Meßwertbereich 0–90 ng/ml. Serielle Bestimmungen an 10 Patienten mit akutem Myokardinfarkt beziehungsweise Angina pectoris (AP) zeigen, daß SMb bei Myokardinfarkt vor CK und CK-MB pathologische Werte erreicht (im Mittel 250±95 ng/ml bei stationärer Aufnahme 3,3±1,4 h nach AP-Beginn). Die gleichzeitig bestimmte NAC-aktivierte CK liegt zu diesem Zeitpunkt noch im Normbereich und erreicht pathologische Werte erst 6,2±1,9 h nach Schmerzbeginn. Der Peak des Serum-Myoglobins liegt mit 506±194 ng/ml 8,8±2,8 h, der der CK mit 905±475 mU/ml 20,0±7,8 h nach Anginabeginn. CK-MB und CK unterscheiden sich im zeitlichen Verlauf nur unwesentlich. Ein Patient mit ausgeprägter AP hat bei sonst unauffälligem Enzymmuster pathologisch erhöhte SMb-Werte. Methodische und klinische Ergebnisse werden diskutiert.
    Notes: Summary A radioimmunoassay was developed to determine serum myoglobin (SMb). 50 healthy persons showed values between 0 and 90 ng/ml. Serial tests of 10 patients following acute myocardial infarction or during angina pectoris (AP) indicated that SMb reached pathological values before CK and CK-MB (average 250±95 ng/ml at the time of hospitalisation which corresponds to 3.3±1.4 h after beginning of angina pectoris). At hospitalisation the simultaneously determined CK was within normal limits and reached pathological values only 6.2±1.9 h after the onset of angina. Maximum of SMb was 506±194 ng/ml occurring 8.8±2.8 h after the beginning of AP, maximum of CK was 905±475 mU/ml occurring 20.0±7.8 h after AP. CK-MB and CK differed only slightly in their time course. One patient with severe AP had pathologically increased SMb values whilst all other enzymes were completely normal. Methodical and clinical results are discussed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1440
    Keywords: Myocardial infarction ; Hodgkin's disease ; Radiation therapy ; Chemotherapy ; Splenectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among a total of 2147 patients admitted to our hospital for acute myocardial infarction between 1978 and 1987, three young patients aged 24, 29, and 39 years had previously been treated for Hodgkin's disease. Staging laparotomy, including splenectomy, had been performed in all three patients. Two patients had both mediastinal irradiation (21 and 27 months before infarction) and chemotherapy. In the first patient, postmortem histologic examination of the coronary arteries revealed fibrotic changes, which were probably induced by radiotherapy. In our second patient, myocardial infarction developed 5 days after vinblastine treatment; early angiography showed thrombotic occlusion of the proximal right coronary artery, which was recanalized using the diagnostic Sones catheter. Subsequent angiography revealed normal coronary arteries. This is, to our knowledge, the first case of documented coronary artery thrombosis after treatment with vinca-alkaloids. In our third patient, neither mediastinal irradiation nor chemotherapy had been performed prior to myocardial infarction. However, a marked increase in platelet counts following splenectomy was observed in this patient. The role of radiotherapy, chemotherapy, and splenectomy with consecutive thrombocytosis as a third possible pathogenic factor for subsequent development of myocardial infarction is discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 67 (1989), S. 1010-1013 
    ISSN: 1432-1440
    Keywords: Acute myocardial infarction ; Erythrocytosis ; Smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 29-year-old heavy smoker presented with an acute myocardial infarction and hematocrit of 70%. At immediate coronary angiography a complete occlusion of the right coronary artery was found. After intracoronary urokinase the coronary arteries were found to be completely normal. Causes for the erythrocytosis other than smoking could be excluded. We conclude that thrombotic coronary occlusion with acute myocardial infarction was caused by erythrocytosis due to heavy smoking.
    Type of Medium: Electronic Resource
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