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  • 1
    Electronic Resource
    Electronic Resource
    Allergen skin test reactivity in an unselected Danish population (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to assess the distribution of allergen skin test reactivity in an unselected Danish population. A total of 793 subjects, aged 15–69 years, were invited, and 599 (75.5%) attended. The skin prick test was performed with standardized allergen extracts of high potency. Skin reactivity occurred in 28.4% of the subjects. The frequency of skin reactivity to the specific allergens ranged from 1.5% (Cladosporium) to 12.5% (Dermatophagoides pteronyssinus), and the frequencies of skin reactivity to the allergen groups (pollen, animal dander, house-dust mites, and molds) were 17.6%, 8.7%, 14.0%, and 3.2%, respectively. Young women appeared to reflect the average skin reactivity. When compared with young women, skin reactivity to animal dander was more probable in young men (odds ratio (OR) value = 2.6; 95% confidence interval (CI) of odds ratio value = 1.1–6.1). Current smokers were less likely than nonsmokers to be skin-reactive to pollen (OR = 0.4; 95%, CI = 0.3–0.7). In conclusion, allergen skin test reactivity was common, and was related to sex, age, smoking history, and probably genetic predisposition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1994.tb00805.x
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  • 2
    Electronic Resource
    Electronic Resource
    Incidence of allergic contact sensitization in Danish adults between 1990 and 1998; the Copenhagen Allergy Study, Denmark (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Studies of incidence of contact allergy in a general population have not been reported. Data from incidence studies may support and direct strategies for prevention of contact allergy and allergic contact dermatitis. Objectives To study the incidence of contact allergy and evaluate risk factors for developing contact allergy in an adult general population sample. Patients and methods In 1990 a random sample of 567 persons of the 15–69-year-old population living in the western part of Copenhagen County (Denmark) was patch tested in a cross-sectional study. In 1998 a follow-up study was performed. Of 540 invited, 365 (68%) were patch tested again. Results In the follow-up study, 37 persons (12%) of the 313 patch-test-negative persons in 1990 had developed one or more positive patch tests (incident contact allergy). Twenty cases (6%) of incident nickel allergy and 25 cases (8%) of incident contact allergy to one or more haptens other than nickel were found. The data indicate that female sex, young age and ear piercing (before 1990) were risk factors for developing nickel allergy. Between 1990 and 1998 metal contact dermatitis was reported in seven women with incident nickel allergy. Six of these women had bought the eliciting item in Denmark before 1995, when vigorous control of the Danish nickel legislation was introduced. Conclusions We found a considerable number of incident cases of contact allergy in the adult population. The results of the study support the actions taken to restrict the use of the allergens most frequently encountered, and to increase the labelling demands to products intended for prolonged contact with the skin or a combined action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04668.x
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  • 3
    Electronic Resource
    Electronic Resource
    Hidradenitis suppurativa - characteristics and consequences (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 21 (1996), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The general characteristics of patients with hidradenitis suppurativa have not been previously described in detail. Although rare complications of the disease have been described, little is known of the average impact of hidra-denitis suppurativa. We have now aimed to describe the general characteristics of the disease and its impact on patients with an established diagnosis of hidradenitis (a= 68) and compare these with those of an unselected general population sample (n= 523).Pierced earlobes were more common in patients than in the controls (P 〈 0·02). Female patients were younger (P= 0·0002) and better educated (p 〈 0·0001), and fewer had been pregnant (P= 0·0006). The median number of treatments prior to referral was two, and an average of 2–7 work days/patient per year were lost due to hidradenitis. The self-reported health of patients was significantly inferior to that of the general population (P 〈 0·001), mainly because of soreness and restriction of movement.Low grade hidradenitis suppurativa therefore has a considerable impact on the health of patients. Previously implied associations with the disease such as the use of cosmetics or oral contraceptives, menstrual cycle and body mass index (BMI) were not confirmed in our study, although they may influence the course of pre-existing disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1996.tb00145.x
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  • 4
    Electronic Resource
    Electronic Resource
    The relationship between IgE-mediated and cell-mediated hypersensitivities in an unselected Danish population: The Glostrup Allergy Study, Denmark (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary In this study, we have assessed the relationship between IgE-mediated and cell-mediated hypersensitivities in an unselected population living in western Copenhagen, Denmark. A total of 793 subjects, aged 15–69 years, were studied. Measurements of total serum IgE prick tests with aeroallergens and patch tests with environmental haptens were performed in 561 (70·7% of 793) subjects. One or more positive prick tests were present in 28·4%, and contact sensitization occurred in 15·2%. When adjusted for the effects of sex and age, the probability of contact sensitization to one or more hapten was independent of serum IgE level (the odds ratio value (OR) = 1.0; 95% confidence interval (CI) = 0·7–1·4), and the probability of contact sensitization was independent of the number of positive prick tests (0R = 1·0; CI = 0·8–1·2). Contact sensitization appeared to be independent of enhanced IgE responsiveness in an unselected adult population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb06967.x
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  • 5
    Electronic Resource
    Electronic Resource
    A link between skin and airways regarding sensitivity to fragrance products? (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Exposure to volatile fragrances is commonplace and may be related to various eye and airway symptoms. Skin exposure to fragrances is known to cause perfume contact allergy and eczema, but it is unknown whether eye or airway symptoms elicited by fragrance products are associated with contact allergy or eczema.Objectives  To investigate if eye and airway symptoms elicited by fragrance products are associated with perfume contact allergy or hand eczema in a population-based sample.Methods  A questionnaire on eye and airway symptoms elicited by fragrance products was mailed to 1189 individuals who had recently participated in a Danish population-based study of allergic diseases. Results from the questionnaire about localization and character of the symptoms were compared with data on patch testing and 1-year prevalence of hand eczema collected during the health examination.Results  Positive, independent and significant (P 〈 0·05) associations were found between eye and airway symptoms elicited by fragrance products and perfume contact allergy (adjusted odds ratios 2·0–3·7) and hand eczema (adjusted odds ratios 1·6–2·6). In further analysis, similar and consistent results were found regarding severity of the symptoms. No associations were found between nickel contact allergy and the symptoms. Female sex and psychological vulnerability were independently associated with eye and airway symptoms elicited by fragrance products, but adjustment in multivariate analysis did not change the results regarding perfume contact allergy and hand eczema.Conclusions  Individuals with perfume contact allergy and/or hand eczema, as opposed to those without, have more frequent and more severe eye or airway symptoms after exposure to volatile fragrance products. Having hand eczema has the greatest impact on reporting eye and airway symptoms elicited by fragrance products.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.06251.x
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  • 6
    Electronic Resource
    Electronic Resource
    Increasing prevalence of allergic rhinitis symptoms in an adult Danish population (1999)
    Copenhagen : Munksgaard International Publishers
    Allergy 54 (1999), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is evidence that the prevalence of respiratory allergy is increasing. This is mainly based on studies in children and young adults. The aim of the study was to compare the prevalences of self-reported symptoms of respiratory allergy among Danish adults in two surveys 8 years apart. Identical questionnaires were mailed to two random general population samples in 1989 and 1997. The response rates were 86.1% (n=3603) and 86.4% (n=817), respectively. The sampling frame and sampling method were identical in both surveys. The changes in the prevalences of symptoms were expressed by sex- and age-adjusted odds ratios comparing 1997 to 1989. We found a significant increase in the prevalence of seasonal rhinitis symptoms (OR=1.6, 95% CI 1.4–1.9), rhinitis symptoms on exposure to pollen (OR=1.6, 95% CI 1.4–1.9), rhinitis symptoms on exposure to furry animals (odds ratio 1.6, 95% CI 1.3–2.0), rhinitis symptoms on exposure to house dust (OR=1.3, 95% CI 1.1–1.6), and breathlessness on exposure to pollen (OR=1.5, 95% CI 1.0–2.0). The observed increases were independent of sex and age. The questionnaire was validated in relation to allergen skin test reactivity in a subgroup of the responders to the 1989 survey. When the estimated associations between symptoms and skin test reactivity were considered, the results suggested an increase in allergy to pollen and animal dander. In conclusion, we found evidence of increased prevalence of allergic rhinitis symptoms associated with skin test reactivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.1999.00180.x
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