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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of Brain Calpains (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 47 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract A new, simple one-step procedure [Karlsson et al. Biochem. J. 231, 201–204 (1985)] for the separation of calpains I and II was used prior to the characterization of these enzymes from rabbit brain, using alkali-denatured casein as the substrate. Enzyme activity was dependent on Ca2+ ions and free -SH groups and was maximal around pH 7.4. Incubation of calpains I and II with Ca2+ in the absence of substrate led to a rapid loss of enzyme activity. Enzyme activity was linear at room temperature and millimolar Ca2+ concentrations. However, when incubation ofcalpain I was performed with micromolar Ca2+ concentrations at room temperature proteolytic activity exhibited a lag period of approximately 10 min. This activation period was not as evident with calpain II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb00724.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunoregulatory Function of T8 and T4 Cells from Synovial Fluid and Blood of Patients with Rheumatoid Arthritis or Other Forms of Chronic Arthritis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 24 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The suppressor effect of synovial fluid (SF) T8 cells and blood T8 cells on the pokeweed mitogen (PWM)-induced T4 cell-dependent immunoglobulin production of autologous blood B cells was studied in nine patients with chronic rheumatic diseases (six patients with rheumatoid arthritis (RA), one patient with juvenile RA, and two patients with other forms of chronic arthritis). The suppressor effect of SF T8 cells was of the same magnitude as that of equal numbers of blood T8 cells from patients and healthy controls. However, the relative number of T8 cells was higher among SF T cells than among blood T cells in several cases. Good synovial T8 cell suppression was also demonstrated in coculture experiments where SF T4 cells and B cells were used. In PPD (purified protein derivative of tuberculin)-stimulated cultures the suppressor effect of SF T8 cells as well as of blood T8 cells from patients and controls was lower than it was in PWM-stimulated cultures. In most patients SF T4 cells showed a much better PWM-induced helper function than did non-fractionated SF T cells. Thus the poor PWM induced helper effect of non fractionated synovial T cells was in some cases mainly due to the suppressor effect of T8 cells, whereas in some cases there was also a deficient helper function of synovial T4 cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb02193.x
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  • 3
    Electronic Resource
    Electronic Resource
    The Effect of 20-Trifluoromethyl Leukotriene B4 on Neutrophil Functional Responses (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 20-triHuoromelhyl-lcLikotriene B4 (20CF3LTB4) is a stable derivative of leukotriene B4 (LTB4) that is not subjected to co-oxidation to less active metabolites. 2OCK3LTB4 was as potent as LTB4 as a chemotactic, adhesion-promoting and aggregatory agent for human neutrophils, but bad only 11 ± 3% of the ability to induce an Oxidative response. Nonetheless, both compounds were equally efficient in order to confer a rapid and monophasic increment of the concentration of cytosolic calcium. The kinetics of the calcium, aggregatory and chemiluminescent responses to 2OCF3-LTB4 were similar to that of LTB4. These findings suggest that the insertion of the trifluoromethyl group into the LTB4 molecule causes a shift of the biological activity profile, suggesting that 20CF3LTB4 binds mainly to high affinity LTB4 receptors. Moreover, the similarity of the response kinetics of LTB4 and 20CF3- LTB4 suggests that the mechanism for the rapid and transient responses of LTB4 is not due to its w-oxidation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01782.x
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  • 4
    Electronic Resource
    Electronic Resource
    T-Cell Helper Activity and B-Cell Function of Synovial and Blood Lymphocytes from Patients with Rheumatoid Arthritis or Other Forms of Chronic Arthritis (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 24 (1986), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The helper effect of T cells on B-cell immunoglobulin (Ig) responses induced by pokeweed mitogen (PWM) or purified protein derivative of tuberculin (PPD) was studied in lymphocytes from synovial fluid (SF) and blood of nine patients with rheumatoid arthritis (RA) and eight patients with other forms of chronic arthritis. In PWM cultures the helper effect of SF T cells on Ig responses (IgG, IgM, IgA) of autologous and allogeneic blood B cells was lower than that of blood T cells (P〈0.01). This decrease was more pronounced in patients with RA than in patients with non-RA. In PPD cultures no significant difference was found between the helper effect of SF T cells and blood T cells on the Ig responses of allogeneic blood B cells or on the IgG response of autologous blood B cells, whereas the helper effect of SF T cells on the IgM and IgA responses of autologous blood B cells was decreased. The Ig responses to PWM or PPD in cocultures of autologous blood B and T cells were not significantly different between patients and healthy controls. The PWM- and PPD-induced Ig responses of SF B cells were lower than those of blood B cells when cocultured with autologous blood T cells. SF B cells produced IgG but usually little IgM and IgA. Thus there was a dysfunction of SF B cells and of SF T cells in a PWM-driven system, but a fairly good helper function of SF T cells in a PPD-driven system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1986.tb02192.x
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  • 5
    Electronic Resource
    Electronic Resource
    TREATMENT OF BARBITURATE POISONING (1954)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 9 (1954), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1954.tb01519.x
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  • 6
    Electronic Resource
    Electronic Resource
    Synovial Cells Responding to a 65-kDa Mycobacterial Heat Shock Protein have a High Proportion of a TcRγδ Subtype Uncommon in Peripheral Blood (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 32 (1990), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have analysed the ability of T cells from synovial fluid mononuclear cells (SFMC) and from peripheral blood mononuclear cells (PBMC) of inflammatory arthritic diseases to proliferate in response to mycobacterial antigens (65-kDa heal shock protein [hsp] of BCG. whole BCG) and to rat collagen type II. The SFMC demonstrated a significantly greater ability to respond to 65-kDa hsp of BCG. and to whole BCG, compared with PBMC from the same patients, With collagen type II, only a small proportion of the patients showed a proliferative response, although with this antigen also SFMC responded better than PBMC. There was no difference between SFMC and PBMC in the response to control antigen (tetanus toxoid), phytohaemagglutinin (PHA), or interleukin 2 (IL-2). A high proportion of cells in SFMC-derived short-term T-cell lines were of TcRγδ type, often exceeding the number of TcRγδ type. There was a significantly higher proportion of TcRγδ cells in the SFMC lines compared with the PBMC lines, and a large part of the TcRγδ cells in she SFMC cultures was CD8+ The SFMC lines had a high proportion of δ- TCS-1+ cells (Vδ1) among their TcRγδ cells, always exceeding the percentages of TiγA+ (Vγ9) and BB3+ (Vδ2) in the PBMC lines, the distribution of TcRγδ subtypes was markedly different, with a TiγA+/BB3+ population in the majority. These data argue for a different subpopulation distribution of TcRγδ cells in synovial fluid compared with peripheral blood of patients with inflammatory arthritic diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1990.tb03191.x
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  • 7
    Electronic Resource
    Electronic Resource
    Characteristics of oligotrophic hardwater lakes in a postglacial land-rise area in mid-Sweden (2002)
    Oxford UK : Blackwell Science Ltd
    Freshwater biology 47 (2002), S. 0 
    Details
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: 1. We describe some remarkable ephemeral, oligotrophic hardwater lakes formed because of land rise in the coastal areas of the Baltic Sea, that are unique in Sweden and probably also worldwide. Two younger, coastal lakes were studied by regular sampling for 1 year and compared with an older (i.e. greater altitude) lake, that passed through the oligotrophic hardwater stage some 3–4000 years ago.2. Despite some differences in composition of the catchment, the two younger lakes were similar with regard to water chemistry and plankton community composition. The concentration of phosphorus was low while nitrogen was high, resulting in very high N/P quotients (101 and 131). Although water colour was moderate, the concentration of organic carbon was extremely high (average values of ≥ 20 μg TOC L–1), consisting mainly of dissolved compounds (DOC).3. While the plankton was poorly developed, sediments in both lakes were covered by a layer of photosynthesising micro-organisms. This substantial `microbial mat', which has not been described in detail before, was up to 15 cm thick and dominated by cyanobacteria and purple sulphur bacteria. The concentration of sediment phosphorus was extremely low (352 μg g–1 dw) in one of the lakes and dominated by organic-bound (residual) phosphorus.4. Deep sediments in the older lake, representing its oligotrophic hardwater period, differed in phosphorus composition from the currently oligotrophic hardwater lakes by having a strong dominance of HCl-extractable (Ca-bound) phosphorus. This indicates that phosphorus, initially organic-bound within the microbial mat, is subsequently bound to calcium. We hypothesise that this is promoted by the environmental conditions created by the benthic photosynthetic activity, in combination with the prevailing hardwater conditions.5. The rich and flourishing microbial community on the sediments may also explain the high concentration of DOC in the lake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2427.2002.00881.x
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  • 8
    Electronic Resource
    Electronic Resource
    Production of very cold, highly charged ions by synchrotron radiation: Comparisons of the ''scalpel'' and ''hammer'' methods
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 262 (1987), S. 106-109 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(87)90197-5
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  • 9
    Electronic Resource
    Electronic Resource
    Characterization of cytochrome P-450-dependent activities in hagfish, dogfish, perch and spectacle caiman
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 94 (1989), S. 99-105 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(89)90017-5
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  • 10
    Electronic Resource
    Electronic Resource
    Calpain and capastatin levels in different organs of the rabbit
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 93 (1989), S. 403-407 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(89)90099-0
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