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  • 1
    Electronic Resource
    Electronic Resource
    The granulocyte colony-stimulating factor produced in the human lung and its effect on liquid movement in the rabbit lung (1994)
    Springer
    Surgery today 24 (1994), S. 1050-1055 
    Details
    ISSN: 1436-2813
    Keywords: granulocyte colony-stimulating factor ; extravascular lung water ; alveolar liquid clearance ; pulmonary resection ; cytokine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Levels of the granulocyte colony-stimulating factor (G-CSF) were determined in the plasma and resected lung tissue from patients who underwent pulmonary resection. Moreover, the effect of recombinant human (rh) G-CSF on the permeability of pulmonary endothelium and on liquid clearance from the alveolar spaces was investigated in rabbits. The plasma levels of G-CSF increased from 30 pg/ml preoperatively to 409 ± 236 pg/ml 3 h postoperatively (P 〈 0.05), while the levels of G-CSF in the resected lung tissue were increased in the alveolar fluid, to 1,834 ± 1,054 pg/ml, and in the pulmonary blood, to 5,466 ± 2,019 pg/ml. It was found that rh G-CSF 25 μg administered into the subcutaneous tissue of rabbits increased extravascular lung water to 3.45 ± 0.26 vs 2.98 ± 0.20 in control experiments (P 〈 0.05); however, rhG-CSF 0.75 pg/kg administered into the alveloar spaces did not affect liquid clearance from the alveolar spaces. The findings of this study led us to conclude that G-CSF is synthesized in the human lung and increases the permeability of pulmonary endothelium, but not liquid clearance across the alveolar epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01367455
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Increased alveolar fluid clearance following thoracotomy: Report of a case and results of an analysis (1997)
    Springer
    Surgery today 27 (1997), S. 762-765 
    Details
    ISSN: 1436-2813
    Keywords: pulmonary edema ; ion transport ; lobectomy ; alveolar type II epithelial cell ; human lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Alveolar fluid clearance was studied in the resected lung of a 58-year-old man who had undergone exploratory thoracotomy 9 days earlier. An isosmolar albumin solution was instilled into the distal air spaces, and the albumin and electrolyte concentrations were measured over 4h. Alveolar sodium and fluid clearance had increased by nearly 200% from the control values in the resected lungs of patients without prior thoracotomy (n=5), and histological examination showed that the number of alveolar type II epithelial cells was markedly elevated. These results suggest that an increase in the number of alveolar type II cells may accelerate alveolar fluid clearance under certain clinical conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02384993
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effects of hypothermia and hyperpotassium on alveolar fluid clearance in the resected human lung (1995)
    Springer
    Surgery today 25 (1995), S. 694-700 
    Details
    ISSN: 1436-2813
    Keywords: pulmonary edema ; potassium concentration ; osmolality ; alveolar epithelium ; lung transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of hypothermia and hyperpotassium on alveolar fluid clearance in the resected human lung was examined by instilling an isosmotic albumin solution with a potassium concentration of 0.3 mEq/l or 20 mEq/l into one segment of a resected lobe within 10 min of surgical removal for bronchogenic carcinoma. The experiments were carried out at 37°C, 25°C, and 8°C over 4h, after which the alveolar fluid was aspirated. Alveolar fluid clearance was calculated by a simple equation using the changes in the albumin concentration of the alveolar fluid. It was found that although hypothermia at 8°C abolished alveolar fluid clearance completely, alveolar fluid clearance at 25°C was not different from that at 37°C. Moreover, although the potassium concentration increased in the alveolar fluid at 37°C and 8°C, hyperpotassium did not affect the alveolar fluid clearance. These findings indicate that the net transport of potassium leans to influx from the alveolar epithelial cells into the alveolar spaces when the alveolar potassium concentration is low, and to efflux from the alveolar spaces when the alveolar potassium concentration is high. Thus, we conclude that hypothermia abolishes alveolar fluid clearance in resected human lungs, but that the potassium concentration in alveolar fluid does not affect alveolar fluid clearance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311485
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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