ISSN:
1437-7799
Keywords:
pirarubicin
;
doxorubicin
;
nephrotoxicity
;
rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Background Our objectives were to determine whether pirarubicin induces nephrotic syndrome or chronic renal failure similar to doxorubicin in rats; and to compare the nephrotoxicity of pirubicin with that of doxorubicin. Methods Wistar rats were given doxorubicin (6.5 mg/kg and 3.25 mg/kg) or pirarubicin (9 mg/kg). The lethal dose 50 for doxirubicin is 13 mg/kg, and for pirarubicin, 18 mg/kg. In the pirarubicin groups, additional doses of 9 mg/kg or 4.5 mg/kg of pirarubicin were given 36 days after the first injection. We measured urinary protein, BUN, serum creatinine, and total cholesterol, and performed histologic studies of the kidneys. Results Rats given doxorubicin (6.5 mg/kg or 3.25 mg/kg) showed severe persistent proteinuria. Hypoalbuminemia and hypercholesterolemia appeared after the doxorubicin injection. BUN and creatinine in the doxorubicin (6.5 mg/kg) group of rats began to increase significantly after 10 weeks, and the rats died within 11 weeks. Pirarubicin groups did not show any significant increase in urine protein after 36 days. After an additional injection of 9 mg/kg of pirarubicin, the rats showed an increase in urine protein. However, the pirarubicin-treated rats did not show nephrotic syndrome or chronic renal failure during the observation period. Conclusion Because pirarubicin has far less nephrotoxicity than doxorubicin, it would be a safer and useful antitumor drug.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02480564
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