Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Involvement of oxidative stress in the accelerated formation of pentosidine in patients with end-stage renal failure (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 4 (1998), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY: Advanced glycation end products (AGEs) have been found to accumulate in the amyloid deposits, skin and plasma of haemodialysis patients (HD), implicating the possible involvement of AGE-modified protein in pathogenesis in dialysis-related amyloidosis. Pentosidine, an AGE cross-link, is a specific marker for AGEs. Plasma pentosidine levels in HD patients were increased dramatically. In the present study, plasma pentosidine, fructoselysine, advanced oxidation protein products (AOPP) and glutathione peroxidase (GSHPx) levels were measured to elucidate the role of oxidative stress in pentosidine formation in nondiabetic HD patients. Plasma pentosidine did not correlate with fructoselysine; plasma AOPP levels were significantly higher than those in normal subjects (201.45 ± 57.93 vs. 55.91 ± 6.57 μmol/L, P〈0.001) and correlated positively with plasma pentosidine in HD patients (r=0.52, P〈0.005); plasma GSHPx levels were significantly lower than those in normal subjects (168.40 ± 65.08 vs. 348.87 ± 86.10 U/I, P〈0.001) and correlated negatively with plasma pentosidine (r=0.54, P〈0.001) in HD patients. Decreased GSHPx levels may lead to the accumulation of hydrogen peroxide. These findings implicate the involvement of oxidative stress in the accelerated formation of pentosidine in uraemia and suggest that pentosidine could be considered as an oxidative stress biomarker to estimate the degree of oxidative-stress-mediated protein damage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.1998.tb00380.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Variable expression of heparan sulfate epitopes in crescents of human glomerulonephritis (1999)
    Springer
    Virchows Archiv 434 (1999), S. 145-151 
    Details
    ISSN: 1432-2307
    Keywords: Key words Carbohydrates ; N-Sulfation ; O-Sulfation ; Immunohistochemistry ; Rapidly progressive glomerulonephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Crescentic glomerulonephritis leads to a rapid loss of renal function. Although glomerular crescents are rich in extracellular matrix (ECM), the composition and genesis of the ECM are incompletely understood. Heparan sulfate (HS) is a major ECM molecule and has polymeric structure of great variability. Recent findings that alterations in HS epitopes are associated with renal pathology prompted us to hypothesize that specific HS epitopes might be expressed in the evolution of crescents. We reviewed clinical records of 724 patients who underwent renal biopsy and found 21 patients with rapidly progressive glomerulonephritis. Immunohistochemistry was performed using monoclonal antibodies (mAbs) against well-defined HS epitopes. One mAb was directed against unsaturated uronic acid residues generated during the selective removal of HS by heparitinase (a), and a further two different mAbs against N-sulfate-enriched and O-sulfate-poor portions of HS (b). Results showed that mAb (a) reacted to ECM of normal, sclerosed and crescentic glomeruli and that mAbs (b) reacted strongly to ECM of fibrocellular crescents but not to fibrous crescents, the periglomerular areas and noncrescentic intraglomerular areas. We concluded there are regional differences in HS epitope expression, although HS are ubiquitous components of glomerular ECM. N-sulfate-enriched and O-sulfate-poor portions of HS might play a role in crescent formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050318
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Predialysis serum albumin concentration and creatinine generation rate do not reflect the same pathophysiologic status (1998)
    Springer
    Clinical and experimental nephrology 2 (1998), S. 44-49 
    Details
    ISSN: 1437-7799
    Keywords: nutrition ; mortality ; hemodialysis ; albumin ; creatinine ; nitrogen balance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Whereas the creatinine generation rate may reflect only the protein nutritional status by way of muscle mass, the predialysis serum albumin concentration may well reflect a variety of aspects of a patient's pathophysiologic status, including the protein nutritional status. The aim of this study was to clarify whether or not serum albumin concentration and the creatinine generation rate reflect the same pathophysiologic status. Methods The risk of death associated with the creatinine generation rate was studied with and without adjustment for the serum albumin concentration in 1588 patients undergoing hemodialysis. A comparison was also made between the death risk associated with serum albumin concentrations with and without adjustment for the creatinine generation rate. Possible correlations between the creatinine generation rate and serum albumin concentration were evaluated. Results The death risk associated with the creatinine generation rate was little changed when adjusted for serum albumin concentration. However, the death risk associated with serum albumin concentration remained high even after being adjusted by the creatinine generation rate. Moreover, the correlation was very weak between the creatinine generation rate and the serum albumin concentration. Conclusions Serum albumin concentration and the creatinine generation rate do not reflect the same pathophysiologic status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02480623
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...