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  • 1
    Electronic Resource
    Electronic Resource
    Weak Intramolecular Exchange Interaction between Two Carbenic Units in a Novel Organic High-Spin Ion. ESR Studies on a Monoanion of Biphenyl-3,3'-diylbis(phenylmethylene) (1995)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 11292-11298 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00150a029
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  • 2
    Electronic Resource
    Electronic Resource
    Novel organic ions of high-spin state. 2. Determination of the spin multiplicity of the ground state and 1H-ENDOR study of the monoanion of m-phenylenebis(phenylmethylene) (1992)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 114 (1992), S. 7470-7475 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00045a020
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Flumazenil does not antagonize the cardiac effects of midazolam in the isolated rat heart-lung preparation (1996)
    Springer
    Journal of anesthesia 10 (1996), S. 190-193 
    Details
    ISSN: 1438-8359
    Keywords: Flumazenil ; Midazolam ; Negative chronotropic effect ; Heart-lung preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the effects of midazolam and flumazenil on cardiac function and metabolism in the isolated rat heart-lung preparation. Wistar rats were divided into five groups (each group:n=8) as follows: (1) control (saline); (2) flumazenil (1.3×10−5M); (3) flumazenil (10−4M); (4) midazolam (60μg·ml−1); and (5) midazolam (60μg·ml−1) and flumazenil (1.3×10−5M). Systolic blood pressure and calculated left ventricular dP/dt maximum in the midazolam or midazolam conbined with flumazenil groups increased significantly in comparison with those in the control group. Heart rate in the midazolam group was lower than that in the control group. However, in the flumazenil group, there were no effects on the hemodynamics. There were no significant differences in the myocardial tissue concentration of ATP, lactate, and glycogen in all groups. In this study, midazolam decreased heart rate; however, flumazenil had no effect on the heart, nor did it antagonize the cardiac effects of midazolam. These results suggest that flumazenil has no effect on the peripheraltype benzodiazepine receptor of the myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471389
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of prostacyclin analogue, OP-2507, on function and metabolism in the ischemic working rat heart (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 446-454 
    Details
    ISSN: 1438-8359
    Keywords: Myocardial ischemia ; Myocardial metabolism ; Prostacyclin analogue OP-2507 ; Working rat heart preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined the effects of a new stable prostacyclin analogue, OP-2507, on myocardial function and metabolism in the ischemic working rat heart preparation. The hearts were perfused with Krebs-Henseleit bicarbonate (KHB) buffer, and whole heart ischemia was induced by one-way aortic valve for 15 min follows by reperfusion for 30 min. In the treated hearts, OP-2507, 20 ng·ml−1, was administered to KHB buffer from the beginning to the end of experiment. During ischemia, coronary flow in the OP-2507 group increased significantly more than that in the control group. The mechanical performance of both groups was impaired after ischemia. However, the recovery of coronary flow, cardiac output, peak systolic pressure and LV dP/dTmax was significantly higher in the treated group than in the control group. The incidence of ventricular fibrillation during reperfusion was 100% and 25% in the control and the OP-2507 groups, respectively. Myocardial ATP content was significantly higher in the treated hearts than that in the control hearts. These results indicate that this stable prostacyclin analogue is beneficial in myocardial ischemia, even without its well known action of preventing platelet aggregation. (Oguchi T, Kashimoto S, Nakamura T, et al.: Effects of prostacyclin analogue, OP-2507, on function and metabolism in the ischemic working rat heart. J Anesth 6: 446–454, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060446
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  • 5
    Electronic Resource
    Electronic Resource
    Functional and metabolic effects of propafenone in the rat heart-lung preparation (1991)
    Springer
    Journal of anesthesia 5 (1991), S. 392-395 
    Details
    ISSN: 1438-8359
    Keywords: Myocardial metabolism ; Propafenone ; Rat heart-lung preparation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of propafenone on cardiac function and myocardial metabolism were assessed in the isolated rat heart-lung preparation. Propafenone 0.3, 3 or 30 µg·ml−1 was administered 5 min after the start of perfusion. Heart rate decreased in the 30 µg·ml−1 group significantly following the drug administration. The highest dose of propafenone (30 µg·ml−1) reduced cardiac output significantly, and this dose was associated with a higher incidence of arrhythmias than the other groups. Although there were no significant differences in myocardial lactate and glycogen concentrations among groups, ATP content in the 30 µg·ml−1 group was significantly less than that in the control group. As therapeutic plasma concentration of propafenone is about 0.6 (range 0.06 to 1.0) µg·ml−1, 30 µg·ml−1 is 50 times greater than its concentration. These results suggest that the negative inotropic and chronotropic effects of propafenone are almost same with those of lidocaine which we have previously reported. (Kashimoto S, Oguchi T, Nakamura T, et al.: Functional and metabolic effects of propafenone in the rat heart-lung preparation. J Anesth 5: 392–395, 1991)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054010050392
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  • 6
    Electronic Resource
    Electronic Resource
    Prostaglandin E1 reduces blood loss during and after resection of lumbar herniated disc (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 294-296 
    Details
    ISSN: 1438-8359
    Keywords: Blood loss ; Herniotomy ; Prostaglandin E1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Controlled hypotension was employed during resection of lumbar herniated disc on 10 patients. Prostaglandin E1 (PG) was used as a hypotensive agent. The systolic blood pressure was lowered less than 100 mmHg in the hypotensive group. The average blood loss during surgery was 95 ± 41 ml for the hypotensive group compared with 154 ± 81 ml for the normotensive group (P ≪ 0.05). The blood loss after surgery was also significantly less in the hypotensive group than in the normotensive group (P ≪ 0.05). We conclude that PG is an effective hypotensive agent on blood loss during and after surgery. (Kashimoto S, Nakamura T, Yamaguchi T: Prostaglandin E1 reduces blood loss during and after resection of lumbar herniated disc. J Anesth 6: 294–296, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060294
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  • 7
    Electronic Resource
    Electronic Resource
    Protective effects of prostaglandin I2 analogues on CPK release in rat’s heart-lung preparation (1991)
    Springer
    Journal of anesthesia 5 (1991), S. 359-362 
    Details
    ISSN: 1438-8359
    Keywords: Creatine phosphokinase ; Heart lung preparation ; Hyperoxia ; Prostaglandin I2 analogues
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of prostaglandin I2 analogues (PGI2-a: op-41483 and op-2507) on oxygen toxicity during hyperoxic perfusion were evaluated in an experiment on isolated rat heart lung preparation, with the release of creatine phosphokinase (CPK) in the perfusate blood. There were no significant differences in heart rate and right atrial pressure between PGI2-a treated and untreated hearts. The CPK release from the heart with oxygen was significantly higher than that of the air (P 〈 0.001). However, the CPK release from the PGI2-a treated hearts was significantly less than that from the untreated hearts (P 〈 0.05). These results indicate that PGI2-a may prevent cell damage which was induced by hyperoxia. (Kashimoto S, Nakamura T, Oguchi T, et al.: Protective effects of prostaglandin I2 analogues on CPK release in rat’s heart-lung preparation. J Anesth 5: 359–362, 1991)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054010050359
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  • 8
    Electronic Resource
    Electronic Resource
    Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 284-288 
    Details
    ISSN: 1438-8359
    Keywords: Cardiac and hepatic metabolism ; Hemorrhagic shock ; Spontaneously hypertensive rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seven spontaneously hypertensive rats (SHRs) and eight Wistar-St rats were used to assess the influence of hemorrhage on myocardial and hepatic energy metabolism. They received 2% halothane and pancuronium, 0.3 mg·kg−1, during preparation. After discontinuation of halothane, blood (2 ml·100 g body weight−1) was gradually withdrawn over a 5 min period from a femoral artery. Thirty min after induction of hemorrhage, the heart and liver were removed and myocardial and hepatic metabolites (ATP, lactate, pyruvate and glycogen) were measured by the enzymatic methods. Acidosis and decreased hematocrit were noted in the both groups after hemorrhage. Mean arterial pressure (MAP) in SHR was significantly higher than that in Wistar rat before hemorrhage. However, there were no significant differences in MAP and heart rate between the two groups after hemorrhage. Although there were no significant differences in cardiac metabolites, a significant decrease of hepatic ATP and an increase of hepatic lactate/pyruvate ratio were found in SHR when compared with Wistar rat. These results suggest that human hypertensive disease may run a high risk in connection with acute hemorrhage. (Kashimoto S, Nonaka A, Nakamura T, et al: Cardiac and hepatic metabolism in spontaneously hypertensive rats following acute blood loss. J Anesth 6: 284–288, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060284
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  • 9
    Electronic Resource
    Electronic Resource
    Divergent intron arrangement in the MB1/LMP7 proteasome gene pair (1996)
    Springer
    Immunogenetics 44 (1996), S. 254-258 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  We sequenced the human MB1 gene from a cosmid clone mapping to chromosome 14q11.2-12. The gene spans about 6 kilobases and contains three exons and two introns. There was no evidence of an alternative leader exon, which is a characteristic of the major histocompatibility complex (MHC)-encoded LMP7 gene, the closest relative of MB1, with which it shares 67% amino acid identity. Conceptual translation of the 5′ end of the gene calls for a cleaved leader sequence of 59 amino acids, consistent with western blot data. None of the MB1 gene’s three exons were coincident with any of the six exons in LMP7. In contrast, in the delta-encoding gene and its counterpart, the MHC-encoded LMP2 gene (59% amino acid identity), all six exons are arranged at equivalent positions in respect to the coding frame. The unique structure of MB1 implies a separate origin or different selection pressures acting at this particular locus. DNA repeat analysis provides information on the minimum time of separation of the MB1/LMP7 pair of genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050121
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  • 10
    Electronic Resource
    Electronic Resource
    The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs (1998)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 358 (1998), S. 275-278 
    Details
    ISSN: 1432-1912
    Keywords: Key words 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone ; O6-methylguanine ; K-ras mutation ; Vitamin E ; Lung tumorigenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to estimate the effect of vitamin E on DNA injury and K-ras point mutation at an early stage of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK)-induced lung tumorigenesis in mice, the present study was carried out. Presupplement with vitamin E about 15 times more than control for a week significantly inhibited NNK-induced O6-methylguanine formation in the lungs of mice at 4 and 168 h after the injection. At 30 days after the NNK injection, the activation of K-ras oncogene with a 12th codon GC→AT transition was detected in 56% of lung samples tested by mutant-allele-specific amplification. Vitamin E supplement reduced the frequency of the mutation to 30%. These results suggest that vitamin E suppresses NNK-induced DNA injury and subsequent fixation of the injury during the initiation and post-initiation phases of the lung tumorigenesis in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005253
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