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  • 1
    Electronic Resource
    Electronic Resource
    Actomyosin-like Protein in Mitochondria of the Mouse Liver (1963)
    [s.l.] : Nature Publishing Group
    Nature 197 (1963), S. 1106-1107 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] This evidence led to the assumption that release of glycolysis-stimulating factors within the cell was related to functioning of the enzymatic contractile system of mitochondrial membranes1'2. On the other hand, it had been suggested by Lehninger that intermediate enzymes of the coupled mechanism ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1971106a0
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of ceruloplasmin biosynthesis in human and monkey liver cells and its copper regulation (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 337-344 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Aus Affenserum (Macacus rhesus) ist das Zeruloplasmin in Form einer homogenen Eiweisssubstanz isoliert und in ihren physikalisch-chemischen Konstanten näher bestimmt worden. Der Vergleich der Eigenschaften des Zeruloplasmins des Menschen und des Affen ergibt eine Ähnlichkeit dieser beiden Substanzen. Bei der Untersuchung mittels spezifischer Präzipitation im Agar haben sich beim Antiserum des Kaninchens Beweisgründe für eine antigene Identität beider Zeruloplasmine ergeben. An Gewebeschnitten der Affenleber inkubiert bei aktiv oxydativer Phosphorylierung ergab sich die Bindung des Zeruloplasmins in vitro. Resynthetisierte Eiweißsubstanz bildet einen spezifischen Niederschlag mit dem Antiserum des Kaninchens, welches gegen das Zeruloplasmin des Menschen immunisiert ist. Mit Hilfe lumineszierender Antikörper ist die spezifische Lumineszenz des Zeruloplasmins nur in parenchimatösen Leberzellen gefunden worden. Die Biosynthese des Zeruloplasmins ist in der Leber lokalisiert. Aus In-vitro-Versuchen an Gewebeschnitten der Leber beim Affen und entsprechenden In-vivo-Versuchen ergibt sich, dass Kupfersalze in geringen Konzentrationen die Biosynthese verstärken, in grossen Konzentrationen hingegen die Biosynthese des Zeruloplasmins hemmen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01899902
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  • 3
    Electronic Resource
    Electronic Resource
    Chromosomal localization of ceruoplasmin and transferrin genes in laboratory rats, mice and in man by hybridization with specific DNA probes (1987)
    Springer
    Chromosoma 96 (1987), S. 60-66 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Fragments of the natural rat ceruloplasmin (Cp) gene and cDNA copies of rat Cp and transferring (Tf) mRNAs highly labelled by nick translation with 125I-dCTP were used as specific probes for assignment of these genes to the metaphase chromosomes of rat, mouse and man by in situ hybridization. Both Cp and Tf genes were found to be syntenic in rodents, occupying with high probability the regions 9D and 9F1–3 in mice and 7q11–13 and 7q31–34 in rats respectively. The significant increase in silver grain count over chromosome 15 in rats after hybridization with both the Cp and Tf probes suggests the presence of a related pseudogene cluster on this particular chromosome and thus favours its partial homeology to chromosome 7. The localization of silver grains in metaphase chromosome of man indicates subregional assignment of the Tf gene to 3q21. Use of the rat Cp DNA probe does not indicate synteny of the Cp and Tf genes in man and suggests the existence of a related DNA sequence in 15q11–13. The potential and limitations of the in situ hybridization technique with heterologous DNA probes for gene mapping in mammalian species are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285885
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  • 4
    Electronic Resource
    Electronic Resource
    On the repression of mitochondrial dna transcription by fructose 1.6-diphosphate and its derepression by cyclic adenosine 3′,5′-monophosphate (1974)
    Springer
    Molecular and cellular biochemistry 3 (1974), S. 165-168 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01659188
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  • 5
    Electronic Resource
    Electronic Resource
    Determinant for multiple drug resistance possessing features of a mitochondrial episome in saccharomyces cerevisiae (1977)
    Springer
    Molecular and cellular biochemistry 14 (1977), S. 19-24 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary A mutation for multiple resistance to tetracycline, cycloheximide and oligomycin appears to be followed by reconstruction of the mitochondrial genome resulting in the formation of independent nucleotide sequences that determine different resistant phenotypes. Heterozygotes for the cross resistance factor lack locus T responsible for relation tetracycline which comes from theα-parent. The nuclear recessive gene-suppressori induces deletion of the whole determinant for multiple resistance. The loss of mt-DNA on ethidium bromide treatment does not lead to the loss of this determinant which remains in the cells either in an active or in a passive state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734160
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  • 6
    Electronic Resource
    Electronic Resource
    On the cell-free system of protein synthesis from mammalian mitochondria (1977)
    Springer
    Molecular and cellular biochemistry 14 (1977), S. 91-96 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Some properties of a submitochondrial cell-free system for protein synthesis are described. The system was prepared from rat liver mitochondria lysed with Triton X-100, and the lysate was characterized by a linear rate of [14C]amino acid incorporation for 15–20 min with subsequent decline in activity. The incorporation reaction was inhibited by chloramphenicol and was in-sensitive to cycloheximide. Poly(U) addition stimulated [14C]phenylalanine incorporation by the preincubated submitochondrial system. Upon the addition of 7.5S mRNA that was iso-lated from mitochondria the major translation product was identified as a hydrophobic poly-peptide which in some properties (solubility in chloroform-methanol mixture) was similar to one of polypeptides synthesized by the sub-mitochondrial system on endogeneous mRNAs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734170
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  • 7
    Electronic Resource
    Electronic Resource
    On the defect of synthesis ceruloplasmin in the liver polyribosomes in Wilson's disease (1975)
    Springer
    Biochemical genetics 13 (1975), S. 533-550 
    Details
    ISSN: 1573-4927
    Keywords: Wilson's disease ; ceruloplasmin ; genetic defect in protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Comparative immunochemical analysis of ceruloplasmin-synthesizing polyribosomes in liver biopsies from control subjects and homozygous carriers of the Wilson's mutation was performed. According to I 125 -antibody binding data, the amount of ceruloplasmin-forming liver polysomes in patients with Wilson's disease was 10–20 times lower than that in non-Wilson patients. Correspondingly, the pulse labeling of ceruloplasmin polypeptides was decreased severalfold in the cell-free liver preparations from patients with Wilson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484913
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  • 8
    Electronic Resource
    Electronic Resource
    Mitochondrial genes and cell heredity (1977)
    Springer
    Molecular and cellular biochemistry 14 (1977), S. 5-10 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary It is well known that mitochondria are only partly an autonomous system since they are subjected to nuclear control. For this reason, in studying mitochondrial genes one has to consider constantly the integration of mitochondrial and nuclear genetic systems. This fact makes experimental approaches still more sophisticated, especially, when one turns from individual genetic structures to mitochondrial heredity on the level of cells and multicellular organisms. Here we shall discuss some theoretical aspects of mitochondrial heredity that have been comparatively rarely dealt with in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734157
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  • 9
    Electronic Resource
    Electronic Resource
    Preproceruloplasmin is a primary product of cell-free translation of ceruloplasmin messenger RNA (1981)
    Springer
    Molecular and cellular biochemistry 35 (1981), S. 159-169 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Biosynthesis of ceruloplasmin was studied in wheat germ extract programmed with polysomal RNA from rat liver. Optimal potassium concentration for the total protein-synthesizing activity and for the synthesis of immunoreactive ceruloplasmin was 96 and 186 mM respectively. 7-methylguanosine 5′-monophosphate caused two-fold inhibition of the cell-free synthesis of ceruloplasmin. Immunoprecipitated ceruloplasmin that was synthesized at optimal potassium concentration was a homogeneous polypeptide of a molecular weight about 84 kD. The addition of membrane fractions from rat liver to the incubation mixture caused the conversion of the 84 kD polypeptide into 80 kD and 65 kD polypeptides that are similar to proceruloplasmins synthesized in rat liver during in vivo pulse labelling. The suggestion is made that 84 kD polypeptide is a primary product of the translation of ceruloplasmin mRNA (preproceruloplasmin).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02357086
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  • 10
    Electronic Resource
    Electronic Resource
    Highly purified ceruloplasmin messenger RNA from rat liver (1981)
    Springer
    Molecular and cellular biochemistry 35 (1981), S. 171-182 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Highly purified ceruloplasmin mRNA was isolated from rat liver polyribosomes. The molecular weight of ceruloplasmin mRNA is in a range from 1.05 to 1.25 · 106 daltons which is large enough to code for a putative precursor of ceruloplasmin (∼700 amino acids). Ceruloplasmin mRNA contains 3′-terminal poly(A) the length of which varies from 38 to 165 nucleotides. The 5′-end of ceruloplasmin mRNA is blocked with confronting m7G residue which is a component of cap I (m7G5′ppp5′XmpAp). The addition of ceruloplasmin mRNA to wheat-germ cell-free system programmed the synthesis of a product that was largely precipitated by anti-ceruloplasmin immunoglobulins. The translation product was homogeneous in polyacrylamide gel-sodium dodecylsulfate electrophoresis. Cell-free translation of ceruloplasmin mRNA was sensitive to inhibition by cap analogue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02357087
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