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  • 1
    Electronic Resource
    Electronic Resource
    Suppressed neutrophil function as a risk factor for severe infection after cytotoxic chemotherapy in patients with acute nonlymphocytic leukemia (1999)
    Springer
    Annals of hematology 78 (1999), S. 73-77 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute nonlymphocytic leukemia ; Chemotherapy ; Infection ; Neutrophil function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Severe infections are a major problem in patients suffering from acute nonlymphocytic leukemia (ANLL) undergoing myeloablative chemotherapy. Possible factors leading to infectious complications in these patients are suppressed immune defense mechanisms existing prior to therapy, including those involving the neutrophil granulocyte department. In this study we investigated whether neutrophil function as measured by oxidative burst and phagocytosis before the start of treatment correlates with the severity of infection after therapy. Forty-four patients were included, 27 men and 17 women. Their median age was 46 years (range 20–70 years). According to the development of infectious complications the patients were assigned retrospectively to group 1 (no or only mild infections, n=29) or to group 2 (severe infection or death due to infection, n=15). The phagocytic activity was significantly reduced in group 2 as compared with group 1 [113.7±13.7 (SEM) vs 170.0±19.2, mean channel fluorescence;p=0.04]. In contrast, the oxidative burst as measured by FMLP stimulation was pronounced but not significantly enhanced in group 2 (24.8±6.1 vs 14.5±3.4, mean channel fluorescence). In conclusion, patients with severe infections after chemotherapy might already have preactivated neutrophils with suppressed function prior to treatment. Thus, evaluating function parameters could help to estimate the individual risk of infection for a patient with ANLL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050475
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Perioperative treatment with Filgrastim stimulates granulocyte function and reduces infectious complications after esophagectomy (2000)
    Springer
    Annals of hematology 79 (2000), S. 143-151 
    Details
    ISSN: 1432-0584
    Keywords: Neutrophil function ; Esophageal cancer ; Filgrastim ; Infection ; Surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: n =27) were measured on days −2, 2, and 10. Neutrophil function was enhanced in the Filgrastim-treated group by factor 1.2 for phagocytosis (p=0.016) and 1.4 for oxidative burst (p=0.154). Leukocyte counts increased from 7.6×109/l (day −2) to a maximum of 45×109/l on day 6. No infection was reported in the study group (mean age 59.7 years; 13 men, seven women) up to 10 days after surgery. In contrast, 23 patients (29.9%) in a historical control group (mean age 56 years; 67 men, ten women) treated at the same center developed infections within the first 10 days (p=0.008). In addition, no postoperative deaths occurred in the study group, compared with 9.1% in the group of historical controls. Thus, in this study, administration of Filgrastim stimulated neutrophil function in patients undergoing esophagectomy, and it might be effective in reducing infectious complications related to the surgical procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050570
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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