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  • 1
    Electronic Resource
    Electronic Resource
    Increased expression of nitric oxide synthase in a subpopulation of rat sympathetic neurons after axotomy – correlation with vasoactive intestinal peptide (1996)
    Springer
    Cell & tissue research 285 (1996), S. 419-425 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Immunohistochemistry ; In situ hybridization ; Sympathetic neuron ; Nitric oxide synthase ; Vasoactive intestinal peptide ; Axotomy ; Neuroplasticity ; Rat (Sprague Dawley)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Nitric oxide synthase (NOS) expression is increased in peripheral sensory and central motor neurons after axotomy. By applying double-labelling immunofluorescence and non-radioactive in situ hybridization, we have investigated the regulation of NOS in axotomized sympathetic rat superior cervical ganglia. Furthermore, co-localization of NOS with vasoactive intestinal peptide, which is also induced by axotomy, has been examined. Very few (〈0.1%) NOS-expressing neurons are observed in control ganglia. Some large cell bodies located at the exit of the internal carotid nerve are additionally immunoreactive for vasoactive intestinal peptide. One week following postganglionic axotomy, the number of NOS-immunoreactive and NOS mRNA-expressing neurons increases but does not exceed 2% of the whole neuronal population. About 20% of these neurons are also immunoreactive for vasoactive intestinal peptide. Preganglionic nerve fibre meshworks that are immunoreactive for NOS in untreated ganglia disappear after ganglionic decentralization, whereas some presumably postganglionic fibres remain visible after combined axotomy and decentralization. The findings are indicative of an increased synthesis of NOS in a small subset of postganglionic neurons of the rat superior cervical ganglion, possibly because of the loss of target-derived factors that inhibit nitric oxide synthesis under normal conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050658
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  • 2
    Electronic Resource
    Electronic Resource
    An ever-expanding story of cyst formation (2000)
    Springer
    Cell & tissue research 300 (2000), S. 361-371 
    Details
    ISSN: 1432-0878
    Keywords: Polycystic kidney disease PKD1 PKD2 Polycystin-1 Polycystin-2 Two-hit hypothesis Stop-signal hypothesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Autosomal-dominant polycystic kidney disease represents one of the most common monogenetic human disorders. The cloning of the PKD1 and PKD2 genes, which are mutated in far more than 90% of the patients affected by this disease, has generated high hopes for a quick understanding of the pathogenesis of cyst formation. However, these expectations have not yet been fulfilled, since the function of both polycystin-1 and polycystin-2, the two proteins encoded by PKD1 and PKD2, still remains a puzzle. In this review, we will highlight some of the characteristics of polycystic kidney disease, briefly touch on polycystin-1, and then go on to describe recent results of experiments with polycystin-2, since the latter is the major focus of our work. We will discuss new evidence which suggests that autosomal-dominant polycystic kidney disease actually behaves recessively on a cellular level. Finally, a model will be presented that tries to explain the available data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410000215
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    Paper (German National Licenses)
    Fulltext
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