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  • 1
    Electronic Resource
    Electronic Resource
    Primary osteosarcoma of the cerebrum with immunohistochemical and ultrastructural studies: report of a case (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 384-388 
    Details
    ISSN: 1432-0533
    Keywords: Key words Extraskeletal osteosarcoma ; Brain neoplasms ; Ultrastructure ; Multinucleated giant cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 57-year-old woman with primary intracerebral osteosarcoma is reported. The tumor was identified by computed tomography as a mass with hemorrhage in the right parietal lobe. The surgical and pathological examinations confirmed an osteosarcoma of intracerebral origin. She suffered from repeated local recurrence of the tumor and died about 1 year after the onset. The pathological findings showed features of osteoblastic osteosarcoma with numerous osteoclast-like multinucleated giant cells. Immunohistochemically, tumor cells were positive for vimentin, and partially for actin. Multinucleated giant cells were reactive with vimentin and CD68 antibodies. Ultrastructurally, tumor cells were rich with rough endoplasmic reticulum. These findings are consistent with the histological features of skeletal or extraskeletal osteosarcoma. This is the third case of primary intracerebral osteosarcoma reported in the literature and the first one analyzed ultrastructurally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310384
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Primary osteosarcoma of the cerebrum with immunohistochemical and ultrastructural studies: report of a case (1994)
    Springer
    Acta neuropathologica 88 (1994), S. 384-388 
    Details
    ISSN: 1432-0533
    Keywords: Extraskeletal osteosarcoma ; Brain neoplasms ; Ultrastructure ; Multinucleated giant cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 57-year-old woman with primary intracerebral osteosarcoma is reported. The tumor was identified by computed tomography as a mass with hemorrhage in the right parietal lobe. The surgical and pathological examinations confirmed an osteosarcoma of intracerebral origin. She suffered from repeated local recurrence of the tumor and died about 1 year after the onset. The pathological findings showed features of osteoblastic osteosarcoma with numerous osteoclastlike multinucleated giant cells. Immunohistochemically, tumor cells were positive for vimentin, and partially for actin. Multinucleated giant cells were reactive with vimentin and CD68 antibodies. Ultrastructurally, tumor cells were rich with rough endoplasmic reticulum. These findings are consistent with the histological features of skeletal or extraskeletal osteosarcoma. This is the third case of primary intracerebral osteosarcoma reported in the literature and the first one analyzed ultrastructurally.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310384
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Co-expression of CD4 and CD8 associated with elevated interleukin-4 in a cord T cell line derived by cocultivating normal cord leukocytes and an HTLV-II-producing simian leukocyte cell line (Si-IIA) (1993)
    Springer
    Journal of cancer research and clinical oncology 119 (1993), S. 137-141 
    Details
    ISSN: 1432-1335
    Keywords: Human-T-lymphotropic virus type II ; Human T cell line ; Human interleukin-4
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new interleukin-2(IL-2)-dependent T cell line, designated CS-IIA, was established by cocultivating normal human cord leukocytes and a lethally X-irradiated HTLV-II-producing simian leukocyte cell line (Si-IIA). CS-IIA showed CD4 dominance during the early culture. However, after addition of IL-2, CS-IIA predominantly co-expressed CD4 and CD8 (69.5%) and also expressed the surface markers CD1−, CD3+, CD19−, CD25+ and HLA-DR+. A significantly elevated level of IL-4 (1697 pg/ml) was observed in the culture supernatant from CS-IIA. In addition, the conversion of phenotype from some CD4+CD8+ cells to CD4+CD8− was demonstrated by the neutralization assay using anti-IL-4 antibody. CS-IIA had a normal human karyotype and was free from Epstein-Barr virus nuclear antigen and immunoreactive with sera of HTLV-I- or HTLV-II-infected patients and anti-HTLV-1, p19 or p24 mAb. The provirus genome of HTLV-II was detected in this cell line by the polymerase chain reaction combined with a digoxigenin-enzyme-linked immunosorbent assay. However, electron microscopy of CS-IIA cells revealed no C-type virus particles in the extracellular space. These results indicate that HTLV-II can be transmitted from an HTLV-II-infected simian leukocyte cell line to human cord T lymphocytes and suggest that co-expression of CD4 and CD8 on T cells may be induced by the high level of IL-4, which can mediate CD8 induction on CD4+ T cell clones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01229527
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Immunoelectron microscopy study on the expression of T-cell markers in human T-lymphotropic virus type II-(HTLV-II-) producing cells (1997)
    Springer
    Medical molecular morphology 30 (1997), S. 125-130 
    Details
    ISSN: 1860-1499
    Keywords: Human T-lymphotropic virus type II ; T-cell receptor ; Lymphocyte marker ; Immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An immunoelectron microscopy study of human T-lymphotropic virus (HLTV) type IIa- and type IIb-producing cells was performed to clarify lymphocyte marker expression including that of T-cell receptor (TCR). Although an immune reaction with TCR antibody β-chain was detected in the rough endoplasmic reticulum, but not the plasma membrane (PM), staining for TCR α-chain antibody was mostly negative in HLTV-IIa- and IIb-producing cells. Moreover. TCR α/β antibody yielded no positive reaction in HLTV-IIa- and-IIb-producing cells, including PM. Both the PM and nuclear membrane in HLTV-IIa- and-IIb-producing cells were positive for CD3; CD25 and HLA-DR were positive for the PM of HLTV-IIa- and-IIb-producing cells. These findings suggest that HLTV-IIa- and-IIb-producing cells are activated T cells expressing CD3, CD25, and HLA-DR antigens, but are immune deficient for antigen recognition because of defective expression of TCR-CD3 complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01545313
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    Paper (German National Licenses)
    Fulltext
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