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  • 1
    Electronic Resource
    Electronic Resource
    Effect of phthalic acid esters on gonadal function in male rats (1979)
    Springer
    Bulletin of environmental contamination and toxicology 21 (1979), S. 65-67 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01685387
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) to serum protein components in rats (1977)
    Springer
    Bulletin of environmental contamination and toxicology 18 (1977), S. 773-777 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01691991
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  • 3
    Electronic Resource
    Electronic Resource
    Mutagenicity of Tama River sediments (1987)
    Springer
    Bulletin of environmental contamination and toxicology 39 (1987), S. 696-700 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01698464
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  • 4
    Electronic Resource
    Electronic Resource
    Distribution and elimination of di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) after a single oral administration of DEHP in rats (1982)
    Springer
    Archives of toxicology 51 (1982), S. 149-155 
    Details
    ISSN: 1432-0738
    Keywords: Di-2-ethylhexyl phthalate ; Mono-2-ethylhexyl phthalate ; Simultaneous determination ; Distribution and elimination ; Biological half-life ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution and elimination of di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) after a single oral administration of DEHP (25 mmol/kg) were studied. A gas-liquid Chromatographic method was used for the simultaneous determination of MEHP and DEHP. The compounds were extracted with methylene chloride and the monoester was alkylated to the hexyl derivative by solid-liquid phase transfer catalysis in methylethyl ketone. The coefficients of variation of this method for determination of DEHP and MEHP were 8.3% and 11.4% respectively. The concentration of DEHP and MEHP in blood and tissues increased to maximum within 6–24 h after dosing, while the highest levels observed in the heart and lungs occurred within 1 h. At 6 h after administration, the highest ratio of MEHP/DEHP (mol%) were recorded in testes (210%) while the other tissues exhibited less than 100%. MEHP disappeared exponentially with t 1/2 values ranging from 23 to 68 h; DEHP t 1/2 ranged from 8 to 156 h and the t 1/2 values of MEHP in several tissues were slightly longer than DEHP. The t 1/2 values in blood were 23.8 h and 18.6 h for MEHP and DEHP, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302755
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  • 5
    Electronic Resource
    Electronic Resource
    Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis (1986)
    Springer
    Archives of toxicology 59 (1986), S. 290-295 
    Details
    ISSN: 1432-0738
    Keywords: Di(2-ethylhexyl)phthalate ; Rats ; Testicularatrophy ; Testicular enzymes ; Zinc concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Daily administration of 2 g/kg/day di(2-ethyl-hexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydrogenase, were lower than those of control by day 10, coincident with degeneration of spermatogenic cells. The specific activities of enzymes associated with premeiotic spermatogenic cells, Sertoli cells or interstitial cells (β-glucuronidase, γ-glutamyl transpeptidase and malate dehydrogenase) were higher than those of control by day 10. The specific activities of alcohol dehydrogenase and aldolase, zinc containing enzymes, increased after DEHP treatment in spite of the decrease in zinc concentration in the testis. In conclusion, changes in several testicular cell-specific enzymes appear to be useful biochemical markers of testicular injury induced by testicular toxicants such as DEHP. However, these changes occurred after or simultaneous with massive histological or morphological changes rather than prior to such changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290553
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of co-administration of Di(2-ethylhexyl)phthalate and testosterone on several parameters in the testis and pharmacokinetics of its mono-de-esterified metabolite (1989)
    Springer
    Archives of toxicology 63 (1989), S. 289-295 
    Details
    ISSN: 1432-0738
    Keywords: Di(2-ethylhexyl)phthalate ; Co-administration ; Mono-2-ethylhexyl phthalate ; Pharmacokinetics ; Testicular atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The administration of 1 g/kg di(2-ethylhexyl) phthalate (DEHP) or 5 mg/kg testosterone for 1 week did not affect the testicular and prostatic gland weights in rats. However, co-administration of DEHP and testosterone induced severe testicular atrophy accompanied by a decrease of zinc concentration in the testis and reduction of the activity of testicular specific lactate dehydrogenase isozyme. These changes were similar to the results of high dose administration of DEHP alone. Values of biological half-life and area under the concentration-time curve (AUC) of mono(2-ethylhexyl)phthalate, the main metabolite of DEHP, in testes after a single co-administration of DEHP (p.o.) and testosterone (i.p.) were higher than those after DEHP administration alone. Results suggest that the co-administration of DEHP and testosterone enhanced the adverse effects of DEHP on testes as the result of changes in pharmacokinetic values of MEHP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278642
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of phthalic acid esters on testicular mitochondrial functions in the rat (1990)
    Springer
    Archives of toxicology 64 (1990), S. 143-147 
    Details
    ISSN: 1432-0738
    Keywords: Di(2-ethylhexyl)phthalate ; Di-n-octyl phthalate ; Mitochondrial respiration ; Monoester metabolites ; Pharmacokinetics ; Testicular atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although it is well established that high dose administration of di(2-ethylhexyl) phthalate (DEHP) and its monoester metabolite (MEHP) induces severe testicular atrophy in rats, the mechanisms of this testicular injury is not clear. The present experiment was undertaken to examine the effects of DEHP and MEHP on mitochondrial functions of rat testis. DEHP and di-n-octyl phthalate (DOP), a DEHP isomer which causes less severe testicular injury, did not inhibit the state 3 oxygen consumption up to 0.65 μmole/ml in vitro. On the other hand, MEHP and mono-n-octyl phthalate (MOP), a metabolite of DOP, inhibited the state 3 oxygen consumption down to a concentration of 0.065 μmole/ml. Testicular mitochondrial respiratory functions of rats administered 2 g/kg DEHP were lower than those of control or DOP-treated rats. These differences were verified by characteristics of pharmacokinetic parameters and testicular concentrations of MEHP and MOP. It may be suggested that a possible mechanism of testicular atrophy induced by DEHP may be due to direct inhibition by MEHP (and partially DEHP) of the respiratory functions of Sertoli cell mitochondria in rat testis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974400
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