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  • 1
    Electronic Resource
    Electronic Resource
    Expression of p53 oncoprotein increases intratumoral microvessel formation in human salivary gland carcinomas (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 28 (1999), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: P53 protein and vascular endothelial growth factor (VEGF) expression, and mean intratumoral microvessel density (IMVD) were studied by immunohistochemistry in 31 salivary gland carcinoma, consisting of 11 adenoid cystic carcinomas (AdCCs), 10 mucoepidermoid carcinomas (MECs), 7 acinic cell carcinomas (AcCCs), and 3 squamous cell carcinomas (SCCs). Cases with p53 protein in more than 20% of tumor cells were detected in one AdCC, four MECs, one AcCC, and two SCCs. Both frequency of p53 and VEGF expression, and mean IMVD, were higher in the MECs and SCCs than in the AdCCs and AcCCs. Similarly, both VEGF expression and mean IMVD were significantly higher (P 0.05) in the eight p53-positive tumors than in the 23 negative tumors. Six cases with survival periods less than 5 years showed significantly higher frequency of p53 and VEGF expression and of mean IMVD than those with longer survival periods. These results indicate that p53 expression might partly correlate with VEGF expression and mean IMVD, and be a factor in the survival of patients with salivary gland carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1999.tb02035.x
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  • 2
    Electronic Resource
    Electronic Resource
    Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel density in human gastric carcinomas (2000)
    Springer
    Virchows Archiv 437 (2000), S. 31-36 
    Details
    ISSN: 1432-2307
    Keywords: Key words Apoptosis ; Gastric carcinoma ; Intratumoral microvessel density ; Thymidine phosphorylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Thymidine phosphorylase (dThdPase) / platelet- derived endothelial cell growth factor (PD-ECGF) is expressed at higher levels in a variety of human carcinomas than in adjacent normal tissue. The higher expression is associated with an increase in intratumoral microvessel density (IMVD) and an unfavorable patient prognosis. This study examined the role of dThdPase in apoptosis, IMVD and p53 expression in human gastric carcinomas. dThdPase expression was noted in 12 (35.3%) of 34 early carcinomas, and in 20 (55.6%) of 36 advanced carcinomas. At least 10 areas consisting of carcinoma cells with diffuse dThdPase expression from the 32 dThdPase-positive tumors (category I), and 10 areas without dThdPase expression from the 38 negative tumors (category II) were selected from each case. For early gastric carcinoma, the mean IMVD was 88.8±19.4 in category I and 61.4±17.3 in category II carcinomas, while for advanced gastric carcinoma, the mean IMVD was 98.8±21.0 in category I and 76.0±27.1 in category II carcinomas. The mean IMVD was significantly higher in category I than in category II tumors (P〈0.05). The mean apoptotic index (AI: percentage of apoptotic cells) was 1.95±1.30 in category I, and 3.76±1.49 in category II carcinomas for early gastric carcinoma, and 1.51±0.98 in category I and 2.14±0.66 in category II carcinomas for advanced gastric carcinoma, the value of the mean AI being significantly (P〈0.05) higher in dThdPase- negative tumors (category II) than in the positive tu-mors (category I), regardless of tumor stage or histological type. There was a significant inverse correlation (P〈0.001) between AI and IMVD. These results indicate that dThdPase expression is associated with both an increase in intratumoral microvessels and a decrease in apoptosis in human gastric carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000205
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  • 3
    Electronic Resource
    Electronic Resource
    A Secure Agent-based Framework for Internet Trading in Mobile Computing Environments (2000)
    Springer
    Distributed and parallel databases 8 (2000), S. 85-117 
    Details
    ISSN: 1573-7578
    Keywords: electronic commerce ; mobile agent ; auction-like negotiation ; secure electronic transaction (SET) ; signcryption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Most of the current Internet trading frameworks, in particular their negotiation and payment phases, are intended for customers frequently connected to the Internet during an entire transaction. This requirement cannot be easily met in the high communication cost and/or low bandwidth settings, typically found in mobile computing environments. Based on the software agent paradigm, a new secure agent-based framework for Internet trading in mobile computing environments is proposed in this paper. The framework is composed of two new protocols. One is the agent-based auction-like negotiation protocol, another is the agent-based payment protocol. Both of them are dedicated to solve the trade problems of Internet trading in mobile computing environments and ensured to be safe by cryptographic technologies. The combination of the two secure protocols constitutes an integrative solution for Internet trading in mobile computing environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008735301014
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    Paper (German National Licenses)
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