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  • 1
    Electronic Resource
    Electronic Resource
    Morphology of the perforating cartilage canals in the proximal tibial growth plate of the chickSupported in part by the USDA Cooperative Agreement 12-14-3001-294. (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 194 (1979), S. 143-157 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Perforating canals arise exclusively from junctional canals just above the reserve zone and they do not branch after entering the proliferative zone. They are uniformly spaced and arranged in parallel array. The cartilage canals terminate near the beginning of the zone of hypertrophic cartilage cells. Vascular components within the perforating canals consist of a central arteriole surrounded by enlarged, interconnected capillaries which are individually in contact with the adjacent cartilage matrix. TEM shows that the capillary endothelium is extremely attenuated, possesses numerous fenestrations and lacks a continuous basement membrane. The central arteriole is enlarged through the midpart of the canal and then narrows to communicate with the capillaries near the bottom of the canal. The large capillaries ascend from their point of origin and recombine near the top of the growth plate to exit as a single venule. The vascular arrangement therefore describes a system in which the outgoing blood runs in close proximity, but counter to, the incoming blood. This vascular arrangement within the perforating cartilage canal would most likely allow the zone of maturing cartilage cells to receive the highest concentration of nutrients.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091940110
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  • 2
    Electronic Resource
    Electronic Resource
    Intranuclear annulate lamellae in giant cells of the mouse chorioallantoic placentaThis study was supported by grant 4314-52 from the University of North Dakota School of Medicine General Research Support Grant. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 176 (1973), S. 101-109 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Intranuclear annulate lamellae were initially observed on day 9 of gestation. They increased in frequency until day 12, after which a decline in frequency was noted. Numerous IAL were in close association with nucleoli on days 11 and 12 and numerous large dilatations of the intermembranous space were present. IAL were also associated with cytoplasmic invaginations and inclusions of the nucleus. The frequency of invaginations and inclusions also increased from day 9 to 12 and brought increased amounts of cytoplasm into contact with the nucleus. Continuity of the intermembranous space of the IAL with the perinuclear space and the latter with the cisterns of rough endoplasmic reticulum suggested a possible route for nuclear-cytoplasmic exchange in either direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091760107
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of lithium carbonate on the structure of the rat kidneyAided by a Department of Health, Education and Welfare, National Institute of Mental Health grant 1-R03-MH-18784-01 (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 134 (1972), S. 97-106 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Female Sprague-Dawley rats were used to study effects of lithium carbonate on the ultrastructure of the rat kidney. Experimental rats received daily intraperitoneal injections of lithium carbonate in dosages of 10, 30 or 100 mg/kg/day. These animals were killed on day 12 to 60. Control rats were either non-injected or injected with either sodium chloride or sodium carbonate. Kidneys from control rats showed no abnormal changes. The 10 and 30 mg/kg lithium carbonate dosages caused progressive mitochondrial swelling, dilatation of cisternae of rough endoplasmic reticulum and occasional swelling of apical cytoplasm in tubular cells localized in the distal portion of the nephron. The 100 mg/kg lithium dosage produced damage in all portions of the nephron. However, the most severe damage, consisting of mitochondrial swelling, dilatation of the rough endoplasmic reticulum, apical cytoplasmic rarefaction and liquefaction, karyolysis and karyorrhexis was noted in the distal convoluted tubules and collecting ducts. The present study demonstrated that low dosages of lithium carbonate do affect the structure of the rat kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001340108
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  • 4
    Electronic Resource
    Electronic Resource
    Morphometric and electron microscopic studies of goiter induced by lithium in the ratPaper presented at the eighty-fifth annual meeting of the American Association of Anatomists, April 3-6, 1972, Dallas, Texas.Supported by grant 1 R03-MH-18784-01, National Institutes of Health. (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 136 (1973), S. 297-303 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Fifty-two male and female albino rats were used. Lithium-treated rats (30 animals) received twice daily intraperitoneal injections of lithium carbonate (40 mg/kg body weight) for 80 days. Three control groups were used. The first remained uninjected; the second received sodium chloride solution equal in volume and tonicity to the lithium carbonate solution; the third received sodium carbonate solution in which the carbonate ion concentration was equivalent to that in the lithium carbonate solution. Thyroid weights were analyzed as wet and dry weights, and as wet and dry thyroid weights in milligrams per 100 gm body weight. Morphometric or electron microscopic studies were carried out on Epon-embedded tissue routinely prepared for light or electron microscopy.Thyroid weights and values were greater in lithium-treated animals. A sex-related effect of lithium was indicated. The differences in thyroid weights between lithium-treated and control male rats were greater than those between female lithium-treated and control rats. Morphometric analysis revealed an increase in the mean diameter of sections of follicles and relative amounts of colloid, and a decrease in follicular cell heights in lithium-treated animals. The electron microscope revealed an enlarged Golgi apparatus in many thyroid follicular cells of lithium-treated rats. The enlargement of the Golgi apparatus was most evident in male lithium-treated animals. The relationship of these findings to the mechanism of lithium action was briefly discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001360304
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    Paper (German National Licenses)
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