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Assessment of skin irritancy in man by laser Doppler flowmetry (1982)

Nilsson, Gert E. ; Otto, Uno ; Wahlberg, Jan E.

Oxford, UK : Blackwell Publishing Ltd

Contact dermatitis 8 (1982), S. 0

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ISSN: 1600-0536

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: It is desirable to use more objective methods than visual storing for the assessment of skin irritancy reactions. In the present study the blood flow in skin sites exposed to sodium lauryl sulfate (SLS) was recorded by a laser Doppler flowmeter. The irritant was applied to the volar forearm of healthy volunteers in concentrations ranginig from 0.001% to 5% under occlusion for 24 h. The test sites were scored visually and the blood flow was recorded at 3 different times: 26 h, 48 h and 72 h after the application of SLS. Approximately 950 recording were performed and a clear relationship was observed the applied doses of SLS, the recorded blood flow values and the corresponding scores. In a few cases a deviation from the general trend was observed, implying that the naked eye might be unreliable for the assessment of skin irritancy reactions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0536.1982.tb04266.x

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Dose-dependence of the pharmacokinetics of quinidine (1977)

Bolme, Per ; Otto, Uno

Springer

European journal of clinical pharmacology 12 (1977), S. 73-76

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ISSN: 1432-1041

Keywords: Quinidine ; pharmacokinetics ; non-linearity ; dose-dependent pharmacokinetics ; steady state plasma level ; oral administration

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Quinidine was administrated orally to five healthy male volunteers. Doses of 0.2 g t. i. d., 0.3 g t. i. d. and 0.4 g t. i. d. were given for five days with at least four weeks between each test period. The plasma concentration of quinidine was measured before the morning dose on Days 2–5 of treatment, and 1, 2, 4 and 8 h after the morning dose on the 5th day. There was not a linear relationship between the increase in dose and the increase in plasma concentration of quinidine. A dose increase of 50% from 0.6 to 0.9 g quinidine sulphate per day resulted in an increase in steady state concentration of 94%. A further 33% increase in dose, from 0.9 to 1.2 g daily, resulted in a 55% increase in the steady stae concentration of quinidine. The results demonstrate dose-dependent pharmacokinetics for quinidine. Possible explanations for the nonlinear pharmacokinetics are discussed.