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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 33 (1995), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 30 (1994), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim was to mimic the repeated open application test (ROAT) procedure, well established in humans, in an animal model. Guinea pigs were induced with cobalt chloride (CoCl2). They were then challenged by repeated open application (4 sites/animal) of various concentrations of the allergen in 10% DMSO 1 × a day for 7 days, to study dose dependency, morphology of test reactions and time course. The reactivity at the test sites to repeated open application was dose-and time-dependent. There was good agreement between the results of the treatments with CoCl2 and the post-treatment patch test results. Among 26 of the 29 animals, such agreement was found when 10% DMSO was used as vehicle. However, some reactivity was also observed in pretests at sites exposed to petrolatum. We suspect that this may be due to contamination and/or irritancy of the vehicle.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 30 (1994), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The report reviews individual-related variables (age, sex. race, anatomical site), intra- and inter-individual variation (temporal, physical and mental activity, food and drugs), and environment-related variables (air convection, temperature). Technical variation, instrument validation including a standard reactive hyperemia experiment, and a standard operating procedure are discussed and included in the guidelines.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 3 (1977), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During a 22-month period, 2.0% cadmium chloride in distilled water was included in our routine patch test series. Twenty-five of 1502 eczema patients showed reactions (1.7 %), but none had any relevant history. At serial dilution test only one patient reacted to 1.0 % cadmium; all the other dilutions applied gave negative reactions. Analysis by atomic absorption spectrophotometry of the cadmium chloride used for patch testing showed that it contained less than 1 μg/g of chromium, copper, cobalt and nickel. The conclusion is that no certain case of contact allergy to cadmium chloride has been revealed. An experimental study using the guinea pig maximization test is in progress.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During 1976–77 a field investigation was carried out into skin diseases among house painters in Stockholm, Sweden. The study was divided into three stages: I. questionnaire investigation, II. examination of painters who reported skin diseases, and III. patch testing and final classification. Of the 2,622 painters registered on 30 November 1976, 2239 (85.4 %) answered the questionnaire. Current dermatoses were reported by 373 painters (16.7 %) and of these, 227 were examined by us, 40 had recently been examined, and 106 did not attend. Occupational contact eczemas were diagnosed in 87 cases, and it was doubtful if the dermatoses were occupational in an additional 56 cases. A prevalence of 3.9 % was suggested, but this represents a minimum figure. Chloracetamide was found to be an important cause of occupational contact eczema. A personal and/or family history of atopy was common among the affected painters. Solvents were widely used for skin cleansing; there is a great need for continuous information on protective measurements, and on skin cleansing and care. It is concluded that field investigations give higher and probably more reliable prevalence figures for occupational dermatoses than data compiled from outpatient clinics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To determine the incidence of patch test reactions to copper, 2% copper sulphate was included incur routine patch test series. The allergic potential of copper sulphate was evaluated by the guinea pig maximization test method (GPMT). 13 of the 1190 eczema patients showed reactions (1.1 %), but they were considered non-relevant. 3 series of GPMT demonstrated that copper sulphate was a grade I allergen. A critical review of the literature disclosed that several reports on cases of allergic contact dermatitis to copper must be regarded as uncertain or non-relevant. 4 eases were considered relevant and another 20 cases probably relevant. It is suggested that a test reaction to copper sulphate should be verified by a serial dilution test (SDT). Furthermore, the sensitivity of patients to other metals should be stated, so that one can be aware that false positive reactions from metal impurities, especially nickel, in the copper salt used for testing may occur.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is desirable to use more objective methods than visual scoring for the assessment of skin irritancy reactions. The edema, or fluid accumulation in the exposed skin sites, can be accurately measured by a caliper and this alternative method of assessment is evaluated from different aspects. Sodium lauryl sulfate (SLS) and non-anoic acid in different concentrations were applied daily to human and animal (rabbit and guinea pig) skin, and a dose-response relationship established. Higher concentrations of the irritants induced an earlier response. With 5% SLS as the test substance and the increase in skin fold thickness as the single parameter of skin irritancy, the guinea pig was found to be less reactive than rabbit and man. Measurement techniques, reproduceability and advantages and disadvantages with different animal models are discussed.
    Type of Medium: Electronic Resource
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