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  • 1
    Electronic Resource
    Electronic Resource
    Isolation of cis-dimethyl(methoxycarbonyl)(triphenylphosphine)gold(III) (1988)
    s.l. : American Chemical Society
    Organometallics 7 (1988), S. 2238-2239 
    Details
    ISSN: 1520-6041
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/om00100a029
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neovascularization of the outermost area of herniated lumbar intervertebral discs (1999)
    Springer
    Journal of orthopaedic science 4 (1999), S. 286-292 
    Details
    ISSN: 1436-2023
    Keywords: Key words: lumbar disc herniation ; histology ; neovasculari-zation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: In 64 surgically treated herniated lumbar intervertebral discs, we performed histopathological studies of neovascularization in the outermost layer of the herniated mass in various types of hernia. We obtained specimens separately from the capsule tissue covering the herniated mass and the inner tip tissue of the herniated mass for comparison. Histologically, in most cases, the capsule tissue was the outermost layer of the annulus fibrosus or posterior longitudinal ligament, and the inner tip tissue was the nucleus pulposus. In the capsule tissue, newly formed small blood vessels were present in 73.4% of the total cases examined, regardless of the hernia type. However, the frequency and degree of such vessels in the tip tissue were significantly higher in hernias that perforated the posterior longitudinal ligament than in those that did not. When the intervertebral disc herniates, new blood vessels proliferate in the capsule of the hernial tissue. At the stage when the hernial capsule tissue is still present, these vessels were observed to have difficulty reaching the inner tip portion. These findings suggest that when the nucleus pulposus portion of the herniated mass perforates the posterior longitudinal ligament, it may be subject to a stronger neovascularization reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760050105
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Identification and partial characterization of a glycoprotein species with high affinity for methylmercury in peripheral nervous tissues of man and experimental animals (1993)
    Springer
    Archives of toxicology 67 (1993), S. 268-276 
    Details
    ISSN: 1432-0738
    Keywords: Methylmercury ; Protein binding ; Peripheral nerves ; Myelin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A small amount of a glycoprotein species (21-kDa glycoprotein) with high affinity for methylmercury (MeHg) was detected in the post-nuclear or post-mitochondrial supernatant fraction of the homogenate of rat sciatic nerve on electrophoresis and autoradiography after binding of Me203Hg to the fraction. The 21-kDa glycoprotein was also found in the subcellular fractions of mouse, hamster, guinea pig, rabbit and human peripheral nervous tissues. Experiments with the cellular fractions of the tissues revealed that the 21-kDa glycoprotein is localized mainly in the myelin fraction, whereas it was not found in the cellular fractions of brain, spinal cord and nonneural tissues, such as kidney and liver. The specific binding activity of the 21-kDa glycoprotein with MeHg was 12–15 fold that of the major myelin protein, Po. It was shown that the interaction of the 21-kDa glycoprotein with MeHg was mediated through sulfhydryl groups in experiments with iodoacetamide and dithiothreitol. The amino acid compositions of the rat and human 21-kDa glycoproteins were similar but very different from that of a typical metallothionein. The N-terminal amino acid sequences of the two components of the rat 21-kDa glycoprotein were identical to those of Po and PMP-22, respectively. The in vitro binding of MeHg was also observed in the myelin fraction obtained from the sciatic nerves of MeHg-dosed rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974346
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  • 4
    Electronic Resource
    Electronic Resource
    Comparative Genomic Hybridization Analysis of Genetic Alterations Associated with Malignant Progression of Meningioma (1999)
    Springer
    Journal of neuro-oncology 41 (1999), S. 167-174 
    Details
    ISSN: 1573-7373
    Keywords: genetic alterations ; meningioma ; CGH ; malignant progression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Little is known about genetic alterations during malignant progression of meningioma. We used comparative genomic hybridization (CGH) in 20 patients (13 with typical, 4 with atypical and 3 with anaplastic meningiomas) to investigate the genetic pathway underlying the development of meningioma. Typical meningiomas displayed only a few genetic changes such as monosomy 22. Anaplastic meningiomas manifested more aberrations than typical meningiomas, frequently exhibiting losses of 1p, 2p, 6q, chromosome 10 and 14q, and gain of 20q, in addition to monosomy 22. The average number of alteration sites in each patient with typical meningioma was significantly less than those in each patient with atypical (p〈0.01) and with anaplastic meningioma (p〈0.05). Anaplastic meningiomas showed the chromosomal changes seen in atypical meningiomas together with other aberrations. These CGH findings suggest that losses of 1p, 2p, 6q, chromosome 10 and 14q, and gain of 20q are genetic changes implicated in the malignant progression of meningioma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006086723607
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  • 5
    Electronic Resource
    Electronic Resource
    Consistency of lumbar discograms of the same disc obtained twice at a 2-week interval: Influence of needle tip position (1998)
    Springer
    Journal of orthopaedic science 3 (1998), S. 243-251 
    Details
    ISSN: 1436-2023
    Keywords: Key words: lumbar dicography ; needle tip position ; same disc ; consistent image rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Although numerous papers have emphasized the importance of accurate needle positioning in lumbar discography, no concrete evidence is available to support this contention, and no study has evaluated the image consistency of discography as influenced by this factor. By observing the consistency of two images in relation to needle tip position we aimed to clarify the importance of needle positioning in discography. One hundred and ninety-two patients (324 discs) receiving steroid intradiscal therapy in whom discography of the same disc was performed twice at a 2-week interval and in whom the needle tip position was within the acceptable range (as defined by us) were studied. The patients were divided into two groups: in group G, in whom the needle tip was within a limited range on both discograms, and group P, in whom the needle tip was in this range on only one discogram. Image consistency was compared roentgenographically in the two groups. The consistent image rate for the total number of discs was 48.5%, being significantly higher in group G (53.2%) than in group P (39.0%). The rates were lower in the nucleus pulposus and the posterior portion of the disc than in the other disc areas, but were significantly higher in group G (85.4% and 75.0%, respectively, for these two areas). The necessity for accurate needle tip positioning was proved roentgenographically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760050049
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    Paper (German National Licenses)
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