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  • 1
    Electronic Resource
    Electronic Resource
    Hemocompatibility of PET (Polyethylene Terephthalate) Films Grafted PEG (Polyethylene Glycol) by Plasma Surface Modification (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 339-342 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In this paper, polyethylene glycol (PEG) of various different molecular weights was grafted onto PET films using plasma surface grafting modification. The surface structure of PEG-grafted PET films was analyzed by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS), suggesting that the surface structure and composition of PET films changes due to the presence of PEG. Blood compatibility was characterized by in vitro platelet adhesion experiments and coagulation factors. The tests of platelet adhesion and coagulation factors in vitro suggest that PEG grafted onto polymer surfaces can improve the blood compatibility of PET films remarkably. The modified PET films were pre-coated with albumin and fibrinogen respectively; platelet adhesion tests in vitro then indicated that samples pre-coated with albumin have better blood compatibility than with fibrinogen, resulting in the conclusion that the albumin can improve blood compatibility. The contact angle of PEG-grafted films was measured by the sessile drop method and the surface free energy andinterface free energy were induced. It is indicated that the PEG-grafted PET films have the characteristic of preferentially adsorbing albumin
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.339.pdf
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Rapamycin/Curcumin Co-Loaded Poly(Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 317-320 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Rapamycin/curcumin co-loaded and rapamycin-loaded poly(lactide-co-glycolide)(PLGA)films were prepared by a casting method. The components of different drug-loaded films wereanalyzed by Fourier transform infrared spectroscopy (FTIR), and the major peaks of rapacymin andcurcumin were both observed in these films. Compared to the rapamycin-loaded film, the results ofin vitro platelet adhesion tests show that the number of adhered platelets reduce, and few aggregatedand activated platelets are observed. The APTTs (activated partial thromboplastin time) ofrapamycin/curcumin co-loaded films is nearly 6 seconds longer than for the rapamycin-loadedPLGA films. All results indicate that curcumin may suppress thrombosis activated by rapamycinloadedfilm, and improve the anticoagulative property. The results of alamar blue indicate that therapamycin/curcumin co-loaded film has better antiproliferation effect than 316 stainless steel (SS)
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.317.pdf
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Anticoagulation and Drug Release Behavior of Curcumin-Loaded PLGA Films (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 342-343 (July 2007), p. 481-484 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Three kinds of curcumin-loaded films (3wt%, 5wt%, 8wt%) were prepared usingpoly(lactic acid-co-glycol acid (PLGA) as the carrier of curcumin, and studied. The result of Fouriertransform infrared spectroscopy (FTIR) and X-ray electron spectroscopy (XPS) show that thecurcumin is dispersed in the PLGA films. High performance liquid chromatography (HPLC)analysis suggests that the release of curcumin can last 22-43 days. A fewer number of adhered andactivated platelets are observed on the curcumin-loaded PLGA films. The activated partialthromboplastin time (APTT) increases for all curcumin-loaded films
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.481.pdf
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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