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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of hyperlipidemia m two patients with analbuminemia
    Amsterdam : Elsevier
    Clinica Chimica Acta 128 (1983), S. 307-319 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(83)90330-3
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  • 2
    Electronic Resource
    Electronic Resource
    Increased reactivity of laminin in the basement membranes of capillary walls in AIDS brain cortex (1991)
    Springer
    Acta neuropathologica 81 (1991), S. 552-556 
    Details
    ISSN: 1432-0533
    Keywords: Acquired immunodeficiency syndrome ; Brain cortex ; Capillary basement membrane ; Laminin ; Collagen IV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To verify how the components of the capillary wall are modified in the course of AIDS we studied the brain cortex from nine cases with AIDS. Cellular and extracellular components were delineated using antibodies for laminin and collagen IV for basement membranes and glial fibrillary acidic protein for astrocyte foot processes. We found a marked increase in reactivity for laminin in the basement membranes of capillary walls and hypertrophy and hyperplasia of astrocyte foot processes around vessels, when compared to control cortical tissue. We suggest that modifications of brain capillary wall may have a role in the pathogenesis of neurological disfunction in AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310137
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  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of Haemagglutinating Particles of Coxsackie B 5 Virus by HeLa Cell Cultures (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 323-324 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The receptor of human erythrocytes for some ECHO viruses is destroyed by chymotrypsin, but not by RDE or trypsin: it appears to be different from the erythro-cyte receptor for myxoviruses and is probably a protein3. In 1962 we isolated from a rectal swab of a child in Ossi (Sardinia) a strain of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209323a0
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  • 4
    Electronic Resource
    Electronic Resource
    Ceftriaxone versus aztreonam plus cefazolin for infections in cancer patients with adequate neutrophil counts (1990)
    Springer
    Infection 18 (1990), S. 166-169 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 154 Fieberschübe bei Krebspatienten mit adäquaten Neutrophilenzahlen (〉1.000 Zellen/mm3) wurden in einer prospektiven randomisierten Studie entweder mit Ceftriaxon (72 Episoden) oder Aztreonam plus Cefazolin (82 Episoden) behandelt. Nahezu die Hälfte der fieberhaften Episoden waren dokumentierte Infektionen. Die Gesamtansprechrate bei den 144 auswertbaren Episoden war für beide Therapien ähnlich: 76% für Ceftriaxon (51/67) und 82% für Aztreonam plus Cefazolin (63/77) (p=0,41; nicht signifikant). Bei mikrobiologisch dokumentierten Infektionen war die Ansprechrate unter der Doppel-Betalaktam-Kombination etwas besser (85 % im Vergleich zu 65%; p=0,16), doch war dieser Unterschied nicht signifikant. Bei den klinisch dokumentierten Infektionen zeigten die mit der Monotherapie behandelten Patienten bessere Ansprechraten (87% gegenüber 59%; p=0,12). Während der Studie wurden keine ernsthaften Nebenwirkungen beobachtet, beide Therapien wurden gut vertragen. In der empirischen Therapie von Infektionen bei Krebspatienten mit adäquaten Neutrophilenzahlen erwiesen sich Ceftriaxon und die Kombination von Aztreonam plus Cefazolin als vergleichbar wirksam.
    Notes: Summary In a prospective randomized trial, 154 febrile episodes in cancer patients with adequate neutrophil counts (〉1,000 cells/mm3) were treated with either ceftriaxone (72 episodes) or aztreonam plus cefazolin (82 episodes). Documented infections represented almost half of the febrile episodes. The overall response rates among the 144 evaluable episodes were similar for the two regimens: 76% (51/67) with ceftriaxone versus 82% (63/77) with aztreonam plus cefazolin (p=0.41, not significant). Although not statistically significant, the response rate of the microbiologically documented infections was slightly better in patients treated with the double β-lactam combination (85% vs. 65%, p=0.16) and clinically documented infections showed a better response in the group of patients receiving monotherapy (87% vs. 59%, p=0.12). No serious adverse effects were observed during this study and both regimens were well tolerated. Ceftriaxone or the combination of aztreonam plus cefazolin showed a similar efficacy as empirical therapy for infections in cancer patients with adequate neutrophil counts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01642106
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  • 5
    Electronic Resource
    Electronic Resource
    Viridans streptococci septicemia in cancer patients: A clinical study (1987)
    Springer
    European journal of epidemiology 3 (1987), S. 316-318 
    Details
    ISSN: 1573-7284
    Keywords: Viridans streptococci ; Bacteremia in cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Viridans streptococci septicemia was documented in ten cancer patients, 7 of whom were neutropenic (〈 1000/mmc). Pneumonia was presumed to be the source of bacteremia in six patients. Viridans streptococci isolated from sputum culture in an immunocompromised host must be regarded as the potential etiological agent, then further characterized and checked for antibiotic sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00149743
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  • 6
    Electronic Resource
    Electronic Resource
    Risk factors for acute parenterally transmitted viral hepatitis: A 20-year study (1993)
    Springer
    European journal of epidemiology 9 (1993), S. 625-628 
    Details
    ISSN: 1573-7284
    Keywords: Viral hepatitis ; Risk factors ; Parenteral transmission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to verify the relative role of each single risk factor during a long period of observation, and to compare the frequency of risk factors in parenterally and non-parenterally transmitted acute viral hepatitis, we studied 1,251 patients admitted to our Department from 1971 to 1991. Acute hepatitis A cases were considered non-parenterally transmitted, whereas B, C, NANB and Delta hepatitis were grouped together as parenterally transmitted. The two groups were compared for age, sex and the following risk factors: surgical procedures, transfusion, dental procedures, intravenous drug addiction, infected partner, infected relative and hospital admission. There were 243 non-parenterally transmitted and 1,008 parenterally transmitted cases. In univariate analysis, mean age in the two groups was 20 and 37 years (p = 0.000001) for non-parenterally and parenterally transmitted cases respectively; mean ages of patients with different parenterally transmitted hepatitis (B, NANB, C, Delta) did not differ significantly (p = 0.35). The following risk factors were significantly more frequent in the parenterally transmitted hepatitis group: surgical procedure (odds ratio = 8.04, 95% confidence intervals: 3.75, 20.51), transfusion (OR= 18.79, 95% Cl: 5.03, 157.72), dental procedures (OR = 2.19, 95% CI: 1.2, 4.06), drug addiction (OR: 11.02: 95% Cl: 4.15, 41.34), and infected partner (OR = 17.61, Cl: 3.02, 708.65). However, logistic regression showed the following factors as being significant: age (p = 0.00001), transfusion (OR = 3.35, 95% CI: 1.61, 6.94), dental procedures (OR = 1.61, 95% Cl: 1.18, 2.2), drug addiction (OR = 4.88, 95% Cl: 2.94, 8.1). Therefore we suggest that, besides considering surgery and - in the near future - transfusion as less important risk factors for acute parenterally transmitted hepatitis, and while continuing social and medical campaigns against drug addiction, special efforts should be concentrated on increasing the use of all possible hygienic measures in dental care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00211436
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  • 7
    Electronic Resource
    Electronic Resource
    Empiric antimicrobial therapy in febrile granulocytopenic patients. Randomized prospective comparison of amikacin plus piperacillin with or without parenteral trimethoprim/sulphamethoxazole (1986)
    Springer
    Infection 14 (1986), S. 261-267 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer prospektiven, randomisierten Studie wurde die Kombination Amikacin plus Piperacillin plus Trimethoprim/Sulfamethoxazol mit der Standard-Zweierkombination Amikacin-Piperacillin in der empirischen Behandlung von Fieberschüben bei granulozytopenischen Patienten verglichen. 161 Fieberepisoden wurden ausgewertet, davon waren 74 mit Amikacin plus Piperacillin und 87 mit Amikacin plus Piperacillin plus Trimethoprim/Sulfamethoxazol behandelt worden. Bei Patienten, die die Antibiotika-Dreierkombination erhalten hatten, war der Gesamt-Therapieerfolg wie auch das Ansprechen mikrobiologisch nachgewiesener Infektionen mit 84% bzw. 82% signifikant besser als bei Patienten, die nur Amikacin-Piperacillin erhalten hatten, mit Ansprechraten von 63% bzw. 60% (p 〈 0,05). Bei Auswertung der Ansprechraten nach Infektionslokalisation oder Erregern fanden sich hingegen keine signifikanten Unterschiede zwischen den beiden Gruppen. Die Zugabe von Trimethoprim/Sulfamethoxazol zu Amikacin-Piperacillin verstärkte offensichtlich die Toxizität der Antibiotikatherapie mit vermehrtem Auftreten von Übelkeit und Erbrechen, doch standen diese Nebenwirkungen eindeutig in Beziehung zur Infusionsgeschwindigkeit von Trimethoprim/Sulfamethoxazol. Die Ergebnisse dieser Studie sprechen für die Verwendung einer Kombination von drei Antibiotika anstelle einer Zweierkombination in der empirischen Therapie von Fieberschüben bei granulozytopenischen Patienten.
    Notes: Summary In a prospective randomized trial parenteral trimethoprim/sulphamethoxazole was added to amikacin plus piperacillin in order to compare triple-drug antibiotic combination with a standard regimen as empiric therapy of fever in patients with granulocytopenia. One hundred and sixty-one episodes were evaluated; 74 episodes with amikacin plus piperacillin and 87 episodes with amikacin plus piperacillin plus trimethoprim/sulphamethoxazole. The overall response to therapy (63% vs. 84%) as well as the response of microbiologically documented infections (60% vs. 82%) was significantly better in patients treated with the triple-drug combination (p 〈 0.05). However, no statistically significant differences in response to antibiotics at different infection sites or with regard to any single pathogen was found between the two groups. Trimethoprim/sulphamethoxazole seemed to be responsible for additional toxicity (nausea and vomiting) when added to amikacin plus piperacillin, but these side-effects were clearly related to the rate of infusion of trimethoprim/sulphamethoxazole. The findings of this study support the use of a three-drug versus a two-drug combination as empiric antibiotic regimen in febrile granulocytopenic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01643959
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  • 8
    Electronic Resource
    Electronic Resource
    Role of antigenemia assay in the early diagnosis and prediction of human cytomegalovirus organ involvement in AIDS patients (1995)
    Springer
    European journal of clinical microbiology & infectious diseases 14 (1995), S. 498-503 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of an antigenemia assay in the diagnosis and prediction of human cytomegalovirus (HCMV) disease in AIDS patients was evaluated. The clinical history of 62 patients with advanced HIV infection from whom a total of 248 blood samples were drawn and tested by the HCMV antigenemia assay was examined retrospectively. Between December 1992 and January 1994, 28 episodes of HCMV disease with organ involvement were recorded; the antigenemia assay was positive in 23 of them (82.1 %). In particular, this test was positive in 11 of 12 (91.6 %) first episodes and in 3 of 3 (100 %) recurrent episodes occurring in patients not receiving maintenance therapy. The same test was positive in 9 of 13 (69.2 %) recurrent episodes occurring in patients receiving maintenance therapy. The first occurrence of HCMV disease was always preceded by a positive antigenemia assay 2 and 4 months before diagnosis (in all 7 patients of the 7 for whom a blood sample was available before HCMV disease). A positive antigenemia test result was not always followed by organ involvement, but a high positive cell count (〉100/200,000 polymorphonuclear leukocytes) strongly correlated with the appearance of HCMV disease in the following 1 to 3 months (100 % of cases). The antigenemia assay is a useful and reliable indirect method for the diagnosis and prediction of HCMV endorgan disease in severely and persistently immunocompromised AIDS patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113427
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