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  • 1
    Electronic Resource
    Electronic Resource
    Italian multicenter study on Epiquick®, Rapid Patch Test® and TRUE TestTM (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 3 (1994), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Using 3 different ready-to-apply patch test systems (Epiquick®= EPI; Rapid Patch Test®= RPT; TRUE TestTM= TT), 316 patients sensitive to at least one allergen were studied in order to investigate the reproducibility of these tests in comparison with the Finn Chamber ®(FC) technique. Each patient was tested with a different ready-to-use system. Each test was compared to the same allergen applied with FC to either side of the upper back. Comparisons were made using EPI, RPT, and TT in 93 (183 tests), 119 (262 tests), and 104 (242 tests) patients respectively. When a positive test result occurred on only one side of the back, the concordance was defined as negative. Similarly, doubtful reactions on either side corresponding to positive or negative results were considered as non concordant. The concordance of positive reactions was 80.9% between the EPI and the FC technique, 77.5% between the RPT and the FC technique, and 72.3% between the TT and the FC technique. The frequency of questionable (+?) and irritant reactions (IR) was about the same for the different tests. Nevertheless, when comparing the positive reactions vs +?, IR, or negative reactions in paired tests, positive results were more frequently obtained with the FC technique. Our data suggest that the standard method with FC allows a better detection of contact allergy than the new ready-to-use systems tested in this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1994.tb00410.x
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  • 2
    Electronic Resource
    Electronic Resource
    Onycholysis and subungual haemorrhages secondary to systemic chemotherapy (paclitaxel) (2003)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 17 (2003), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Paclitaxel is a chemotherapic agent of the taxane family used in treatment of malignant solid tumory. We report here the case of a 40-year old woman referred to our clinic for nail changes involving all 20 digits and developed after 5 months of paclitaxel intake, due to a breast carcinoma.Clinical examination revealed red-brown discoloration of the nails associated with hematomas and onycholysis. The nail changes were very painful and the patient complained of discharge of bad-smelling yellow brown opaque fluid from underneath the nail plate.Hemorrhagic onycholysis and subungual abscesses are a possible side effect of taxane treatment that should be early recognized to prevent serious complications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2003.00774.x
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  • 3
    Electronic Resource
    Electronic Resource
    Management of androgenetic alopecia〈link href="#fn1"〉★〈/link〉 (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 12 (1999), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Androgenetic alopecia (AGA) is the most frequent cause of hair loss affecting up to 50% of men and 40% of women by the age of 50.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsThis paper outlines the current status of diagnosis and offers guidelines for optimal management of AGA in both men and women.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsThe diagnosis of AGA can usually be confirmed by medical history and physical examination alone. A trichogram can be useful to assess the progression of the hair loss. A scalp biospy is diagnostic but usually not required. In women with signs of hyperandrogenism, investigation for ovarian (polycystic ovarian disease) or adrenal (late-onset congenital adrenal hyperplasia) disorders is required. Mild to moderate AGA in men can be treated with oral finasteride or topical minoxidil. Oral finasteride at the dosage of 1 mg/day produced clinical improvement in up to 66% of patients treated for 2 years. The drug is effective for both frontal and vertex hair thinning. Medical treatment with finasteride or minoxidil should be continued indefinitely since interruption of therapy leads to hair loss with return to pretreatment status. Mild to moderate AGA in women can be treated with oral antiandrogens (cyproterone acetate, spironolactone) and/or topical minoxidil with good results in many cases. Hair systems and surgery may be considered for selected cases of severe AGA both in men and in women.〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionsPatients with AGA should be informed about the pathogenesis of the condition. If used correctly, available medical treatments arrest progression of the disease and reverse miniaturization in most patients with mild to moderate AGA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1999.tb01030.x
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  • 4
    Electronic Resource
    Electronic Resource
    Patients at risk of onychomycosis – risk factor identification and active prevention (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 19 (2005), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives  The aims of this workshop were to identify risk factors for onychomycosis and to reach consensus on the management of high-risk groups to allow the development of guidelines to help doctors recognize risk factors that complicate treatment.Results and Conclusions  Previous Trichophyton rubrum infection, older age, abnormal nail morphology, immunodeficiency and genetic factors were identified as risk factors for initial infections. Risk factors for recurrence (relapse and re-infection) are largely the same.The experts agreed that the prevention of onychomycosis and its recurrence should be based on the correct treatment of tinea pedis, screening family members and adequate patient education.In addition, generic management recommendations for each high-risk group were discussed:〈list xml:id="l1" style="custom"〉• Immunosuppressed patients〈list style="custom"〉◆ Usual dose and treatment length not appropriate◆ Follow-up required◆ Beware of drug interactions• Diabetics〈list style="custom"〉◆ Prophylactic foot care combined with nail treatment◆ Good opportunity for patient education, footwear, foot care, etc.◆ Beware of drug interactions• Psoriatics and patients with abnormal nails〈list style="custom"〉◆ Dermatophyte eradication does not restore normal nails• Children〈list style="custom"〉◆ High failure rate possibly due to compliance problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.2005.01282.x
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  • 5
    Electronic Resource
    Electronic Resource
    Loratadine and cetirizine in the treatment of chronic urticaria (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 3 (1994), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim This study was designed to compare loratadine and cetirizine in controlling the symptoms of chronic urticaria.Subjects One hundred and sixteen adult patients with chronic urticaria.Methods In this double-blind study the patients were randomly divided into three therapeutic groups: 38 received loratadine (10 mg), 40 cetirizine (10 mg) and 38 placebo tablets once daily for 28 days. Steroid-dependent subjects and patients with physical urticaria or with angioncurotic hereditary oedema as well as pregnant or breast-feeding women were excluded from the study. A suitable wash-out period was observed in case of previous treatments for the same disease. Itching, erythema, number of lesions and diameter of the largest one were evaluated according to a scale from 0 (absent) to 3 (severe). The minimum entry study score for itching plus number of lesions had to be at least equal to three. Control visits were scheduled after 3, 7 and 14 days of therapy. Symptoms, disease status, therapeutic response, side effects and compliance were evaluated at each visit. Diary cards were filled in by patients at home.Results Active drugs compared to placebo significantly reduced global clinical symptoms (p 〈 0.05). Loratadine was more rapid in developing its activity than the other two agents (p 〈 0.01 at day 3). Each single symptom showed the same trend. At the end of the study 24 (63%) patients treated with loratadine, 18 (45%) with cetirizine and 5 (13%) with placebo were free from symptoms. Four failures occurred with loratadine, six with cetirizine and seventeen with placebo. The tolerability profile was similar for all three groups. One patient receiving cetirizine dropped out due to severe gastric pain.Conclusions Loratadine is more active and safer than cetirizine in the treatment of chronic urticaria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1994.tb00089.x
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacoeconomics – an aid to better decision-making (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 19 (2005), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives  The first aim of this workshop was to define pharmacoeconomic concepts and terminology. Pharmacoeconomics can be defined as the branch of economics that uses cost-benefit, cost-effectiveness, cost-minimization, cost-of-illness and cost-utility analyses to compare pharmaceutical products and treatment strategies. Economic evaluations provide healthcare decision-makers with valuable information, allowing optimal allocation of limited resources. However, pharmacoeconomics is based on long-term benefits, whereas physicians are typically forced to seek immediate savings. The second aim was to review pharmacoeconomic studies in the field of onychomycosis and finally to discuss future perspectives.Results and Conclusions  We discussed current pharmacoeconomic issues on the management of onychomycosis. Consensus was reached on the following issues:〈list xml:id="l1" style="custom"〉• Published pharmacoeconomic studies concerning onychomycosis are flawed. Future studies should be based on internationally validated principles and appropriate models. The fact that costs of different drugs, laboratory examinations and physician visits vary worldwide should be considered. Cost-benefit studies are required.• The National Institute for Clinical Excellence (NICE) recommendations are often considered in countries other than the UK, even when not adapted to the country in question.• Generic drugs might reduce costs, but this depends on their effectiveness (bioavailability).• Sampling requests affect the economic cost (dependent on methodology, which depends on country) and physicians often trust their instincts even when tests are repeatedly negative.• The cost of adverse event management is usually considered to be 10%; this may be too high for onychomycosis, as treatments are relatively safe without severe side-effects.• Probability of recurrence for each drug should be determined.• Need for disease severity standardization, definition of diagnostic criteria and successful treatment (mycological and clinical cure).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.2005.01285.x
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation of sexual function in subjects taking finasteride for the treatment of androgenetic alopecia (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 15 (2001), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Our practical experience indicates that sexual side-effects in subjects taking finasteride 1 mg (Propecia®) for androgenetic alopecia are much less common than reported in the literature.〈section xml:id="abs1-3"〉〈title type="main"〉ObjectiveTo evaluate the sexual function in subjects taking finasteride (1 mg) compared with age-matched controls using the International Index of Erectile Function (IIEF).〈section xml:id="abs1-4"〉〈title type="main"〉MethodsThe IIEF, a brief, reliable questionnaire, was self-administered to 236 patients taking Propecia® and 236 age-matched males attending the Department of Dermatology of the University of Bologna.〈section xml:id="abs1-5"〉〈title type="main"〉ResultsStatistical analysis showed no differences between scores obtained with the IIEF in subjects taking finasteride and controls.〈section xml:id="abs1-6"〉〈title type="main"〉ConclusionsThe sexual and erectile function of subjects taking finasteride does not significantly differ from that of age-matched controls. This is consistent with the experience of many dermatologists who do not see sexual or erectile dysfunction in patients taking Propecia®.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2001.00315.x
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  • 8
    Electronic Resource
    Electronic Resource
    ‘Deep’ white superficial onychomycosis due to molds (2002)
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 16 (2002), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-3083.2002.00559_1.x
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  • 9
    Electronic Resource
    Electronic Resource
    Contact stomatitis due to N, N-dimethyl-para-toluidine (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 22 (1990), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1990.tb01533.x
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  • 10
    Electronic Resource
    Electronic Resource
    Occupational contact dermatitis due to sodium pyrithione (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 22 (1990), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1990.tb01538.x
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