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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 966-967 
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The role of apoptosis in neurodegenerative disorders remains controversial. Most of the uncertainty derives from the fact that (i) since these diseases progress over years, the possibility of finding a single dying cell in vivo is extremely remote, (ii) tissues are from end-stage patients and ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Key words p27/kip1 ; Oligodendrogliomas ; Histological grading ; Prognosis ; MIB-1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract p27/kip1 regulates the G1-S transition of the cell cycle by inhibiting cyclinD-CDK4, cyclinE-CDK2 and cyclinA-CDK2 complexes. Regulation of p27 levels occurs mainly post-translationally by ubiquitin-mediated proteasomal proteolysis. Although genetic changes of p27/kip1 are extremely rare, in many human carcinomas p27 levels are reduced, correlate with histological malignancy, and are associated with poor prognosis. In astrocytic gliomas, p27 decreases with anaplasia and is almost absent in glioblastomas. p27/kip1 was immunohistochemically studied in 37 oligodendrogliomas, categorized according to WHO classification. In this series, the immunohistochemical reaction for p27 was confined to nuclei. p27 score showed a tendency to decrease with malignancy. When the p27 score was considered as high versus low expression (cut-off of p27 labeling index, LI, at 25%), it represented an independent prognostic factor in univariate (P = 0.02) and in multivariate analysis (P = 0.04). The risk ratio suggested that the p27 low expression group had a threefold increased possibility to show a reduced survival. Moreover, p27 levels did not correlate with MIB-1 LI, suggesting that p27 is not merely associated with the control of proliferation.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-5233
    Keywords: Blood glucose ; Gastroduodenal ulcer ; Insulin secretion ; Potential diabetes ; Serum insulin ; Tolbutamide i.v. administration ; Tolbutamide test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Resume Les AA. ont conduit une étude sur la réponse de l'insulinémie (IRI après administration intraveineuse de tolbutamide chez 13 sujets affects d'ulcère gastrique. Les résultats obtenus suggèrent une baisse de la sécrétion insulinique dans ces sujets. On fait l'hypothèse que l'état ulcératif et flogistique de la muqueuse puisse altérer la sécrétion normale des substances hormonales stimulantes la sécrétion insulinique par des cellules compétentes gastroduodénales.
    Abstract: Resumen Les AA. han efectuado un estudio en 13 pacientes ulcerosos sobre la respuesta insulinémica (IRI) al cabo de suministración intravenosa de tolbutamida. Los resultados obtenidos demuestran disminución de la secreción insulínica en este grupo de pacientes. Se presume que el estado ulcerativo y flogístico de la mucosa, provoca alteración de la secreción normal de las células gastroduodenales competentes, de substancias hormono-símiles que estimulan la secreción de insulina.
    Notes: Riassunto Gli AA. hanno condotto su 13 pazienti ulcerosi uno studio sulla risposta insulinemica (IRI) alla somministrazione endovenosa di tolbutamide. I risultati ottenuti depongono per una diminuita secrezione insulinica in questo gruppo di pazienti. Si prospetta l'ipotesi che lo stato ulcerativo e flogistico della mucosa alteri la normale secrezione, da parte delle cellule gastro-duodenali competenti, di sostanze ormonosimili stimolanti la secrezione insulinica.
    Type of Medium: Electronic Resource
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