ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A total synthesis of salmon calcitonin is described. The C-terminal nonapeptide amide 24-32 was coupled with the heptapeptide 17-23. The resulting hexadecapeptide amide 17-32 was reacted with the heptapeptide 10-16 to give the tricosapeptide 10-32. This was condensed with the N-terminal nonapeptide 1-9, yielding the protected dotriacontapeptide amide 1-32. After removal of the protective groups and purification by gel-filtration the free peptide obtained exhibited the physical, chemical and biological properties of the natural hormone. Its hypocalcaemic activity (ca. 3500 MRC U/mg) is 20-30 times higher than that of porcine or human calcitonin.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19690520702
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