ISSN:
1365-2036
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Aim : To compare the effect of effervescent ranitidine, almagate (magnesium carbonate-aluminium hydroxide) and placebo on gastric pH, in fasting and postprandial conditions.Methods : Twelve healthy volunteers underwent a gastro-oesophageal pH monitoring on three different occasions after the administration of each of the following randomly allocated treatments: almagate, effervescent ranitidine and placebo. Treatment effects were assessed in fasting and postprandial conditions. Onset and duration of alkalinization, percentage of time with pH 〉4 and median gastric pH after treatments were calculated in both periods.Results : Onset of action of effervescent ranitidine was similar to almagate in fasting [median 1.2 min (IQR: 0.6–12.7) vs. 2.9 min (0.4–227.6)] and postprandial conditions [1.4 min (0.5–4.9) vs. 4.1 min (1.3–63.8)] and both were significantly faster than placebo [fasting 211.1 min (2.7–240); postprandial 240 min (175.6–240)]. The duration of action of effervescent ranitidine was statistically significant longer than almagate in fasting [235 min (105.2–239.4) vs. 19.4 min (6.7–38.8)] and postprandial conditions [171.8 min (133.2–239.5) vs. 61.3 min (44.7–91.9)]. Effervescent ranitidine was more effective than almagate in increasing the percentage of time with a pH 〉4 both in fasting (73.9% vs. 7.3%) and postprandial (59.1% vs. 21.3%).Conclusions : Effervescent ranitidine shows an effect on gastric pH as fast as almagate but provides a duration of alkalinization longer than almagate, in both fasting and postprandial conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2036.2004.02178.x
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