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  • 1
    Electronic Resource
    Electronic Resource
    Levels of circulating immune complexes in patients with ovarian cancer (1982)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 89 (1982), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Sera from patients with ovarian tumours were assayed for circulating immune complexes (CIC) by four well established assays based on the interaction of immune complexes with components of the complement system. There was no difference in control, pre- or post-operative or BCG-treated patients' sera. Levels were also unchanged in sera in antigen excess. In patients with ovarian tumours therefore the measurement of CIC would appear to be of little value as a screening test, as a guide to the extent of disease, prognosis or therapy. In a small pilot therapy-trial there was no difference in the survival rate between patients with stage III and IV ovarian cancer treated with cyclophosphamide plus BCG and those who received only cyclophosphamide. Treatment with BCG was associated with postoperative pyrexia and a prolonged hospital stay.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1982.tb03621.x
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  • 2
    Electronic Resource
    Electronic Resource
    Tumor Antigens and Tumor-Host Relationships (1976)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 27 (1976), S. 151-163 
    Details
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.me.27.020176.001055
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  • 3
    Electronic Resource
    Electronic Resource
    Embryonic Antigen Expression on Experimental Rat Tumours (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 20 (1974), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1974.tb00142.x
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  • 4
    Electronic Resource
    Electronic Resource
    Identification of an Anti-Human Osteogenic Sarcoma Monoclonal-Antibody-Defined Antigen on Mitogen-Stimulated Peripheral Blood Mononuclear Cells (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 18 (1983), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An anti-human osteogenic sarcoma monoclonal antibody (mouse IgG2b) termed 79 IT/36 was found to exert complement-dependent cytotoxicity against phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear (PBMN) cells. This reaction was examined by flow cytofluorimetry using indirect membrane immunofluorescence to detect cell-bound antibody and by measurement of the binding of fluroscreen-isothiocyanate-conjugated 791T/36 antibody to cells. The antibody reacted strongly wiih peripheral blood blast cells induced by PHA, and there was negligible reactivity wiih resting lymphocytes. Maximum binding was observed after 3 days' culture with PHA, coinciding with maximum DNA synthesis, and this represented of the order of 2 × 105 antibody molecules bound per cell. After cell surface radioiodination of PHA-stimulated PBMN cells, detergent lysis and immunoprecipitation of antigen wiih 791T/36 antibody and Sepharose-protein A, the apparent molecular weight of this antigen was determined to be 72,000 by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. This is identical to that of the 791T/36-defined antigen expressed on various osteogenic sarcoma cell lines [3, 17], and by this criterion the antigen is distinguishable from other cell surface markers of activated human lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1983.tb00873.x
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  • 5
    Electronic Resource
    Electronic Resource
    IMMUNOBIOLOGY OF RAT NEOPLASIA (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 276 (1976), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1976.tb41632.x
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  • 6
    Electronic Resource
    Electronic Resource
    Tumour markers with unknown functions in gynaecological neoplasia (1980)
    Springer
    Archives of gynecology and obstetrics 229 (1980), S. 325-331 
    Details
    ISSN: 1432-0711
    Keywords: Immune complexes ; Gynaecological neoplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pre- and post-operative ovarian cancer patients' sera were examined for the presence or circulating immune complexes using a variety of assay procedures. In contrast to findings with breast cancer patients' sera, sera from patients with other gynaecological tumours or with preclinical disease diagnosed by cytology, no evidence was obtained to indicate that circulating immune complexes were associated with ovarian cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02108583
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  • 7
    Electronic Resource
    Electronic Resource
    Expression of monoclonal-antibody-defined antigens in fractions isolated from human breast carcinomas and patients' serum (1995)
    Springer
    Cancer immunology immunotherapy 40 (1995), S. 132-137 
    Details
    ISSN: 1432-0851
    Keywords: Breast cancer ; MUC1 mucin ; Immune complexes ; Western blotting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to examine tissue from patients with breast carcinoma or benign breast disease for the presence of monoclonal-antibody-defined antigens, including the MUC1 mucin and carcinoembryonic antigen CEA. The tests were performed by sodium dodecyl sulphate/polyacrylamide gel electrophoretic separation of proteins, electrophoretic transfer to nitrocellulose membranes and immunostaining with the monoclonal antibodies. Some of the antigens identified are known to circulate at high levels in some but not necessarily all, breast carcinoma patients. Serum from a panel of ten breast cancer patients was subjected to a fractionation procedure designed to release antigen from immune complexes, and again these smaples were analysed for the presence of monoclonal-antibody-defined antigens. A high frequency of positive reactions was detected by the anti-MUC1 monoclonal antibody C595 with both breast carcinoma subcellular membrane fractions as well as antigen fractions eluted from circulating immune complexes. No reactions were observed with equivalent materials from benign breast disease samples. The findings illustrate the variability in antigen expression between breast tumours. The data also indicate that a proportion of patients respond to their tumour by the production of antibodies that recognise the MUC1 antigen in their circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01520296
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  • 8
    Electronic Resource
    Electronic Resource
    Induction of immunity to chemically-induced rat tumours by cellular or soluble antigens (1978)
    Springer
    Cancer immunology immunotherapy 3 (1978), S. 247-252 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Radiation-attenuated, aminoazo dye-induced rat hepatoma cells were employed as a standard immunogen in tests evaluating the optimal conditions for the demonstration of resistance to subcutaneous challenge with viable tumour cells. These tests revealed that maximal sensitivity for the detection of the immunogenicity of γ-irradiated cells was obtained using multiple immunisations via the intraperitoneal route rather than the subcutaneous route. When 3 M KCl extracts of tumours (as soluble tumour antigens) were evaluated for the induction of specific immunoprotection under comparable conditions, weak resistance to tumour was demonstrable, but only within a restricted dose range of the antigen preparation. No significant effects upon tumour growth were observed in rats pretreated with fractions of tumour-bearer serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00200078
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  • 9
    Electronic Resource
    Electronic Resource
    Reactivity of an anti-(human gastric carcinoma) monoclonal antibody with core-related peptides of gastrointestinal mucin (1991)
    Springer
    Cancer immunology immunotherapy 33 (1991), S. 80-84 
    Details
    ISSN: 1432-0851
    Keywords: Monoclonal antibody ; Antigenic peptides ; Gastric carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A murine anti-(human gastric carcinoma) monoclonal antibody, GL-013 (IgG1), which reacts with a high-molecular-mass glycoprotein from colorectal tumour tissue [Yang and Price (1989) Anticancer Res 9: 1707], was examined for reactivity against a panel of purified and partially purified antigens associated with tumours of the gastrointestinal tract. These included carcinoembryonic antigen (CEA), normal cross-reacting antigen, Y-hapten glycoproteins, and perchloric acid extracts and glycolipid preparations from colorectal tumours. While the GL-013 antibody failed to bind to these antigens, it was found to react strongly with synthetic peptides with sequences based upon that reported for the protein core of a human gastrointestinal mucin [Barnd et al. (1989) Proc Natl Acad Sci USA 86: 7159; Gum et al. (1989) J Biol Chem 264: 6480]. In control tests, a series of other anti-(colorectal tumour) antibodies (IgG1 and IgG3), with broad reactivity towards gastrointestinal carcinomas, as well as an anti-CEA antibody, (IgG1) failed to react with the synthetic peptides. It is concluded that the anti-(gastric carcinoma) monoclonal antibody GL-013 binds to a threonine-rich peptide epitope expressed within the protein core of gastrointestinal mucins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01742533
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  • 10
    Electronic Resource
    Electronic Resource
    Detection of polymorphic epithelial mucins in the serum of systemic breast cancer patients using the monoclonal antibody, NCRC-11 (1990)
    Springer
    Cancer immunology immunotherapy 31 (1990), S. 269-272 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum from patients with systemic breast cancer was found to contain elevated levels of polymorphic epithelial mucin (PEM) as detected using an immunoradiometric assay employing the monoclonal antibody NCRC-11. PEM was partially purified from pooled sera from these patients and the complex, polymorphic, high-molecular-mass (〉400 kDa) mucin was identified by sodium dodecylsulphate/polyacrylamide gel electrophoresis, Western blotting and immunostaining with the NCRC-11 antibody. Serial serum samples from 16 patients with metastatic breast cancer were assayed for circulating PEM defined by the monoclonal antibody NCRC-11. The clinical course of disease in these patients was assessed independently as progressive, static or responsive. Increasing NCRC-11 antigen levels correlated with disease progression in 6/7 patients, and decreasing antigen levels correlated with an objective response to treatment in 5/6 patients. Measurement of NCRC-11-defined PEM antigen in patients undergoing therapy for metastatic breast cancer showed an overall accuracy of 75%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740933
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