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  • 1
    Electronic Resource
    Electronic Resource
    Stabilization of asthma prevalence among adolescents and increase among schoolchildren (ISAAC phases I and III) in Spain (2004)
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Most studies show a steep increase in asthma prevalence in the last decades, although few studies had applied the same methodology. Recent reports point out the possibility that the epidemic has come to an end. We have studied the prevalence of asthma in a very large sample of children, repeating the study eight years apart.Methods:  Repeated cross-sectional studies using the International Study of Asthma and Allergies in Childhood (ISAAC) protocol in a sample of Spanish schoolchildren 6–7 (parent-reported) and 13–14 (self-reported) years old in 1994–95 (phase I) and 2002–2003 (phase III). The number of participants was 42 417 in phase I and 42 813 in phase III. The participation rate was over 87% (13–14 years) and 70% (6–7 years).Results:  The prevalence of wheezing in the previous year in children aged 13–14 years was 9.0 and 9.3% for boys and 9.6 and 9.2% for girls for phases I and III, respectively. Children 6–7 years of age showed a substantial increase in wheezing in the previous year (7.0 and 10.7% for boys and 5.3 and 8.2% for girls). Other symptoms and severity indexes followed the same patterns.Conclusions:  In the last 8 years, the prevalence of asthma has not changed in 13–14-year-old Spanish children but has increased substantially in 6–7-year olds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00562.x
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  • 2
    Electronic Resource
    Electronic Resource
    Different serum interleukin-12 and sCD30 levels in food- and pollen-sensitized children (1999)
    Copenhagen, Denmark : Munksgaard International Publishers
    Pediatric allergy and immunology 10 (1999), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It has been proposed that a down-regulation of interleukin (IL)-12 and interferon (IFN)-γ might be related to susceptibility to allergy in early life. The aim of this study was to assess serum IL-12 levels in food-sensitized and pollen-sensitized children and to compare these with another activation marker, sCD30. Twenty children with pollen allergy and 22 food-sensitized children were included. The diagnosis of immunoglobulin (Ig)-E-mediated allergy, suggested by clinical symptoms, was based on skin-prick tests, serum IgE antibodies and total IgE levels. Samples from 24 non-allergic children were used as controls. IL-12 and sCD30 levels were measured by ELISA. It was found that pollen-sensitized patients had normal IL-12 and higher sCD30 levels than controls (114 vs. 63 U/ml, p = 0.028), but, surprisingly, food-sensitized infants showed normal sCD30 and increased serum IL-12 levels (323 vs. 118 pg/ml, p = 0.0001). No differences were found in patients suffering from asthma or allergic dermatitis. Levels of sCD30 and IL-12 determined in May showed a strong correlation with those obtained in November. Interleukin-12 and IgE levels had an inverse correlation (r = –0.494, p = 0.0001) whereas no correlation was found between sCD30 and IgE. Age had a strong negative influence on IL-12 levels in allergic (Z = 4.834, p 〈 0.0005) and in normal children (Z = 3.00, p 〈 0.002); by contrast, sCD30 levels were not significantly age-dependent. When IL-12 levels from the food-allergy group were compared with those from normal controls younger than 4 years of age, the difference remained significant (p =  0.001), ruling out an age-bias. The conclusions made in this study were that serum IL-12 and sCD30 showed different behaviors in children with food or pollen allergy. We found IL-12 and sCD30 levels in pollen-allergic patients that agree with the classical T-helper (Th) 1/Th2 paradigm of allergy. In contrast, serum IL-12 levels were increased in food-sensitized children, suggesting a different immunologic pathogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1399-3038.1999.00039.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lack of association between atopy and RsaI polymorphism within intron 2 of the PcεRI-β gene in a Spanish population sample (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 53 (1998), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The B genotype of RasI polymorphism located within intron 2 of the Fc-lgE receptor I (Fc.Rl) gene was previously found to be increased in atopic patients from a Japanese population sample. Methods We studied these A/B genotypes in 70 Spanish atopic patients, and the results were compared to those of 51 nonatopic controls. RasI polymorphisms were studied by specific digestion of polymerase chain reaction fragments followed by polyacrylamide gel electrophoresis. Results The polymorphism frequency (A/A: 25/70, A/B: 28/70, B/B: 17/70) found in patients did not differ from the frequency in nonatopic control subjects. Conclusions We did not find RasI polymorphisms associated with atopic disease. The genetic findings in atopy and asthma may be very different according to ethnic and local characteristics, and they must be carefully verified in difFerent population samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1998.tb03819.x
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  • 4
    Electronic Resource
    Electronic Resource
    Allotetraploid hybrids between citrus and seven related genera produced by somatic hybridization (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 577-582 
    Details
    ISSN: 1432-2242
    Keywords: Key words  Citrus cultivar improvement ; Germ plasm expansion ; Protoplast fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract   We have developed an efficient protoplast-fusion method to produce somatic hybrid allopolyploid plants that combine Citrus with seven related genera, including four that are sexually incompatible. In this paper we report the creation of 18 new allotetraploid hybrids of Citrus, including ten among sexually incompatible related genera, that may have direct cultivar potential as improved citrus rootstocks. All hybrids were confirmed by cytological and RAPD analyses. If fertile, the attributes of these hybrids may be amenable to further genetic manipulation by breeding at the tetraploid level. Wide somatic hybridization of Citrus via protoplast fusion bypasses biological barriers to the natural allopolyploidization of Citrus, and creates new evolutionary opportunities that would be difficult or impossible to achieve by natural or conventional hybridization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050166
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  • 5
    Electronic Resource
    Electronic Resource
    Anti-immunoglobulin antibodies in children with Schönlein-Henoch syndrome. Absence of serum anti-IgA antibodies (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 103-106 
    Details
    ISSN: 1432-1076
    Keywords: Schönlein-Henoch syndrome ; IgA ; IgG ; Anti-IgA antibodies ; Rheumatoid factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Circulating immune complexes (CIC) that simultaneously contain IgG and IgA are frequently found in IgA nephropathy (IgA-N) and the Schönlein-Henoch syndrome (SHS). The presence of anti-immunoglobulin antibodies (IgA anti-IgG and IgG anti-IgA) was studied by ELISA in the serum of 39 children with SHS and compared to 30 normal children. The mean level of IgG anti-IgA antibodies (240±104 u/ml) in SHS patients was similar to control values (251±85 u/ml); the IgA anti-IgG antibodies were increased, although only the antibodies against Fc fraction of IgG were elevated (185±71 u/ml in patients vs 127±24 μ/ml in controls,P〈0.0001) without a significant increase of IgA anti-IgGFab antibodies (141±54 μ/ml vs. 137±25 u/ml); 16/39 (41%) of the patients had increased levels of IgA anti-IgGFc and 6 of these had also high IgA anti-IgGFab. None of these patients had high IgA anti-IgGFab antibodies without simultaneous augmentation of IgA anti-IgGFc. Only 3/39 (7.7%) of SHS patients showed high levels of IgG anti-IgA antibodies. The correlation of IgA anti-IgGFc antibodies with IgA anti-IgGFab was very strong (P〈0.0001) but lower with IgG anti-IgA antibodies (P〈0.002). In addition, 8/39 children had renal involvement, nevertheless in these patients the findings were quite similar, with a non-significant elevation of IgA anti-IgGF ab antibodies. These results show that the IgA anti-IgG antibodies are more frequently increased than IgG anti-IgA antibodies in the SHS; moreover they are mainly directed against Fc fraction and are IgA-FR isotype. Our findings suggest that the CIC in SHS are likely formed by the reaction of IgA antibodies against IgG and not vice versa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959218
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  • 6
    Electronic Resource
    Electronic Resource
    Anti-immunoglobulin antibodies in children with Schönlein-Henoch syndrome. Absence of serum anti-IgA antibodies (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 103-106 
    Details
    ISSN: 1432-1076
    Keywords: Key words: Schönlein-Henoch syndrome – IgA – IgG – Anti-IgA antibodies – Rheumatoid factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Circulating immune complexes (CIC) that simultaneously contain IgG and IgA are frequently found in IgA nephropathy (IgA-N) and the Schönlein-Henoch syndrome (SHS). The presence of anti-immunoglobulin antibodies (IgA anti-IgG and IgG anti-IgA) was studied by ELISA in the serum of 39 children with SHS and compared to 30 normal children. The mean level of IgG anti-IgA antibodies (240±104 u/ml) in SHS patients was similar to control values (251±85 u/ml); the IgA anti-IgG antibodies were increased, although only the antibodies against Fc fraction of IgG were elevated (185±71 u/ml in patients vs 127±24 u/ml in controls, P〈0.0001) without a significant increase of IgA anti-IgGFab antibodies (141±54 u/ml vs 137±25 u/ml); 16/39 (41%) of the patients had increased levels of IgA anti-IgGFc and 6 of these had also high IgA anti-IgGFab. None of these patients had high IgA anti-IgGFab antibodies without simultaneous augmentation of IgA anti-IgGFc. Only 3/39 (7.7%) of SHS patients showed high levels of IgG anti-IgA antibodies. The correlation of IgA anti-IgGFc antibodies with IgA anti-IgGFab was very strong (P〈0.0001) but lower with IgG anti-IgA antibodies (P〈0.002). In addition, 8/39 children had renal involvement, nevertheless in these patients the findings were quite similar, with a non-significant elevation of IgA anti-IgGF ab antibodies. These results show that the IgA anti-IgG antibodies are more frequently increased than IgG anti-IgA antibodies in the SHS; moreover they are mainly directed against Fc fraction and are IgA-FR isotype. Our findings suggest that the CIC in SHS are likely formed by the reaction of IgA antibodies against IgG and not vice versa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01959218
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Allotetraploid hybrids between citrus and seven related genera produced by somatic hybridization (1996)
    Springer
    Theoretical and applied genetics 92 (1996), S. 577-582 
    Details
    ISSN: 1432-2242
    Keywords: Citrus cultivar improvement ; Germ plasm expansion ; Protoplast fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have developed an efficient protoplast-fusion method to produce somatic hybrid allopolyploid plants that combine Citrus with seven related genera, including four that are sexually incompatible. In this paper we report the creation of 18 new allotetraploid hybrids of Citrus, including ten among sexually incompatible related genera, that may have direct cultivar potential as improved citrus rootstocks. All hybrids were confirmed by cytological and RAPD analyses. If fertile, the attributes of these hybrids may be amenable to further genetic manipulation by breeding at the tetraploid level. Wide somatic hybridization of Citrus via protoplast fusion bypasses biological barriers to the natural allopolyploidization of Citrus, and creates new evolutionary opportunities that would be difficult or impossible to achieve by natural or conventional hybridization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224561
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  • 8
    Electronic Resource
    Electronic Resource
    Helicobacter pylori seroepidemiology in risk groups (1994)
    Springer
    European journal of epidemiology 10 (1994), S. 299-301 
    Details
    ISSN: 1573-7284
    Keywords: Antibody response ; Curved bacilli ; Gastric pathology ; Helicobacter pylori
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Helicobacter pylori is associated with peptic ulcer and chronic active gastritis. The response to infection can be determined by measuring serum titers of anti-H.pylori antibodies. We compared antibody liters in 612 serum samples from 570 individuals considered at risk forH. pylori infection, 170 of them are control sera from 110 adults and 60 children with no gastric alterations. The study groups were 93 institutionalized mentally handicapped children, 40 heterosexual couples, 101 HIV-sero-positive patients, 86 patients with chronic renal failure and 40 individuals (20 adults and 20 children) with symptoms associated with gastritis or gastro duodenal ulcer disease. In the adult and child control groups, 33.5% and 11.6% of the individuals had circulating anti-H.pylori antibodies. Significantly more adults (80%) and children (75%) with gastric symptoms had detectable circulating antibody titers. Elevated titers were also found in institutionalized children and in adults with renal failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719353
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