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  • 1
    Electronic Resource
    Electronic Resource
    Asymmetric approach to Pauson-Khand bicyclization. Enantioselective formal synthesis of hirsutene (1990)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 9388-9389 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00181a048
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids fromTrypanosoma cruzi (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 880-881 
    Details
    ISSN: 1420-9071
    Keywords: Trypanosoma cruzi ; benznidazole ; Chagas' disease ; American trypanosomiasis ; chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Epimastigotes ofTrypanosoma cruzi (Tulahuen strain Tul 0 stock) biotransform benznidazole (N-benzyl-2-nitro-1-imidazone acetamide) to reactive metabolites that bind covalently to DNA, proteins and lipids of the parasite. These effects might be related to the trypanocidal action of benznidazole, a chemotherapeutic agent against Chagas' disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941187
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  • 3
    Electronic Resource
    Electronic Resource
    Carbon tetrachloride activation by highly purified liver mitochondrial preparations (1984)
    Springer
    Inflammation research 15 (1984), S. 664-667 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Highly purifled rat liver mitochondrial preparations were found to be able to activate CCl4 to reactive metabolites that bind covalently to lipids. Part of the process is of an enzymatic nature, but most of it is non-enzymatic, The enzymatic mitochondrial CCl4 activation operates more efficiently under anaerobic conditions; it requires NADPH, is CO sensitive, is inducible by phenobarbital pretreatment and is only weakly inhibited by high concentrations of cyanide or azide. The non-enzymatic mitochondrial CCl4 activation is not inhibited by CO and proceeds equally well under air or nitrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966789
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  • 4
    Electronic Resource
    Electronic Resource
    Pit lakes: their characteristics and the potential for their remediation (2000)
    Springer
    Environmental geology 39 (2000), S. 1254-1260 
    Details
    ISSN: 1432-0495
    Keywords: Key words Mine ; Pit lake ; Geochemistry ; Remediation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Pit lakes form when open-pit mining operations are discontinued and dewatering ceases. The increase in open-pit metal mining since the 1970s will lead to the formation of numerous pit lakes over the next 50 years. Many of these lakes will develop acid sulfate conditions with high levels of dissolved metals. Approaches to remediation of these conditions that have been recommended include the addition of lime or other alkaline materials and the stimulation of sulfate-reducing bacteria. However, prevention rather than remediation is probably the preferable approach. Measures to prevent oxidation of mining waste and wall rocks, including measures to fill pits quickly with water, to inhibit the activity of acidophilic sulfur-oxidizing bacteria, and to promote anoxic conditions at the lake bottoms may minimize the formation of acids and dissolved metals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002549900100
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of inhibitors of the FAD-containing monooxygenase system from rat liver microsomes on monomethylhydrazine metabolism and activation to reactive metabolites (1986)
    Springer
    Archives of toxicology 59 (1986), S. 64-66 
    Details
    ISSN: 1432-0738
    Keywords: Monomethylhydrazine ; Liver ; Monooxygenase ; Metabolism ; Activation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several inhibitors of the FAD-containing monooxygeanse (FAD-MO) system from rat liver microsomes (imipramine, chlorpromazine, mercaptoethylamine, dithiothreitol, naphthylthiourea, phenylthiocarbamide) and one inhibitor of the liver microsomal cytochrome P-450 (P-450)-mediated biotransformations (SKF 525 A), were tested as possible inhibitors of monomethylhydrazine (MMH) biotransformation to CO2 and to reactive metabolites that bind covalently to nucleic acids and proteins. Results confirm previous suggestions that both FAD-MO and P-450 are involved in MMH metabolism to CO2 and suggest a similar participation of both systems for production of reactive metabolites interacting with macromolecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263961
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  • 6
    Electronic Resource
    Electronic Resource
    Evidence for hydroxyl free radical formation during paraquat but not for nifurtimox liver microsomal biotransformation. A dimethyl-sulfoxide scavenging study (1988)
    Springer
    Archives of toxicology 62 (1988), S. 355-358 
    Details
    ISSN: 1432-0738
    Keywords: Dimethylsulfoxide ; Hydroxyl free radicals ; Paraquat ; Nifurtimox
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of several experimental conditions on methane (CH4) production from dimethylsulfoxide (DMSO) in incubation mixtures containing liver microsomes and NADPH generating systems was studied. The process was heat sensitive in part but a significant fraction was non-enzymatic in nature. CH4 formation from DMSO was not significantly modified by 2-diethylaminoethyl-2,2-diphenylvalerate. HC1 (SKF 525 A) or EDTA 1 mM and significantly enhanced under an atmosphere of (CO 80%+O2 20%) rather than under air. A marked increase in CH4 production was observed when paraquat (PQ) was included in incubation mixtures but not when nifurtimox (Nfx) was added. Results support the hypothesis of hydroxyl free radical (·OH) formation during PQ biotransformation but cast doubts about its production for the case of Nfx. The low temperature gas chromatographic separation of d3-CH4 from CH4 described opens the future possibility for detecting trace formation of ·OH in vivo, without interference from fecal CH4 formation by administering d6-DMSO to animals and collecting exhaled gases produced, in chambers containing the entire animal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293623
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  • 7
    Electronic Resource
    Electronic Resource
    Antioxidative stress therapy with dithiothreitol tetraacetate I. Protection against carbon tetrachloride induced liver necrosis (1993)
    Springer
    Archives of toxicology 67 (1993), S. 547-551 
    Details
    ISSN: 1432-0738
    Keywords: Carbon tetrachloride ; Dithiothreitol ; Dithiothreitol tetraacetate ; Oxidative stress ; Liver injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dithiothreitol (DTT) is kown to prevent or even reverse several deleterious effects of radiation or of chemical agents operating via free radical and oxidative stress. However, its use has been hampered by its chemical instability and toxic properties. In this work, we synthesized and characterized dithiothreitol tetraacetate (DTT-Ac) which is less toxic and chemically stable, and we provided GLC/MS evidence that it is able to rapidly generate fully deacetylated DTT in liver after its administration to rats. Treatment with DTT-Ac simultaneously with CCl4 or 3 h after the hepatotoxin was able to significantly prevent the CCl4-induced liver necrosis at 24 h after poisoning. DTT-Ac administration was able to significantly reduce the intensity of the covalent binding of CCl4 reactive metabolites to microsomal lipids (CB), but it did not prevent the CCl4-induced initiation of a lipid peroxidation (LP) process as evidenced by diene hyperconjugation of microsomal lipids. Results suggest that DTT-Ac protective effects might be due to its in vivo conversion to DTT which in turn would decrease the intensity of CB via different potential mechanisms to be explored. Protection cannot be attributed to decreases in levels of CC4 reaching the liver or to chain breaking effects on LP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969267
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  • 8
    Electronic Resource
    Electronic Resource
    Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis (1993)
    Springer
    Archives of toxicology 67 (1993), S. 386-391 
    Details
    ISSN: 1432-0738
    Keywords: Quinacrine ; Carbon tetrachloride ; Liver ; Phospholipase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously reported that treatments stimulating phospholipid (PL) synthesis or preventing PL degradation were late preventive agents against CCl4-induced liver necrosis. Later studies by others postulated that stimulation of phospholipase A2 (PLA2) plays a role in PL degradative processes responsible for CCl4 damage. Quinacrine (QUIN) is a well known inhibitor of PLA2. In this work we report that QUIN (150 mg/kg i.p.) partially prevents CCl4-induced liver necrosis at 24 h when given 30 min before or 6 or 10 h after CCl4 (2.5 ml/kg p.o.) QUIN administration does not modify at 1 or 3 h after poisoning CCl4 levels reaching the liver, covalent binding of CCl4 reactive metabolites to proteins or lipids, CCl4-induced lipid peroxidation process, CCl4-induced decreases in body temperature, or glutathione levels in liver. QUIN concentrations in liver at times from 1 to 24 h are well over those required to inhibit PLA2 activity. Results are compatible with the hypothesis that CCl4 activation of PLA2 at late stages of poisoning plays a role in CCl4-induced liver necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01977399
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  • 9
    Electronic Resource
    Electronic Resource
    Readiness to recover in adolescent anorexia nervosa: prediction of hospital admission (2005)
    Oxford, UK : Blackwell Publishing
    The @journal of child psychology and psychiatry 46 (2005), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Objectives:  To determine if motivation to change in anorexia nervosa during treatment is a predictor of hospitalisation in adolescent patients.Method:  The Anorexia Nervosa Stages of Change Questionnaire (ANSOCQ), the Eating Disorders Inventory-2 (EDI-2) and the Beck Depression Inventory (BDI) were administered to a group of 70 anorexia nervosa patients (mean age 15.6 years). They were all receiving treatment at a specialised Eating Disorder Unit and were at different points in the treatment programme. Admission during 6–9 month follow-up was recorded in 63 of these patients who had been admitted to the Unit. The other 7 patients were contacted by phone to determine if they had been hospitalised in another unit during the follow-up period.Results:  Patients who needed hospital admission during follow-up had higher mean scores at first evaluation on some of the EDI-2 scales and on the BDI, lower ANSOCQ scores and were more likely to have been outpatients at first evaluation. In the logistic regression analysis a low ANSOCQ score and being an outpatient at first evaluation were shown to be independent predictors of hospitalisation during follow-up.Conclusions:  Low motivation to change, depressive symptomatology and some EDI-2 scales are related to the necessity of hospital admission in adolescent patients with anorexia nervosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.2004.00360.x
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  • 10
    Electronic Resource
    Electronic Resource
    Photoallergy – musk ambrette (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 9 (1983), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1983.tb04418.x
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