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  • 1
    ISSN: 1432-1041
    Keywords: diabetes mellitus ; Bay m 1099 ; Type II diabetic patients ; desoxynojirimycin ; alpha-glucosidase inhibitor ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Bay m 1099 is a newly developed inhibitor of intestinalα-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a standardized diet and were treated either with Bay m 1099, b.d. (100 mg before breakfast and dinner) or placebo for 3 days, according to a double-blind cross-over design. The postprandial blood glucose level was significantly lower during Bay m 1099 treatment compared to placebo after breakfast and dinner (AUC after breakfastp〈0.001). The reduced postprandial hyperglycaemia was associated with a decrease in meal stimulated serum insulin and C-peptide levels. Thus, Bay m 1099 may be a useful addition in the treatment of Type II diabetic patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1420
    Keywords: Key words Ethylene dichloride (EDC) ; intoxication ; cardiogenic shock ; percutaneous cardiopulmonary bypass ; Schlüsselwörter Ethylene-Dichloride (EDC) ; Vergiftung ; kardiogener Schock ; Herzlungenmaschine ; perkutan implantierbare
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ethylen-Dichlorid (EDC) ist ein technisches Lösemittel, zusätzlich wird es bei der Herstellung von Kunststoffen und Insektiziden industriell verwendet. Vergiftungen entstehen durch Inhalation, Ingestion und Resorption über intakte Haut. 20 ml gelten als tödliche Dosis. EDC greift in den Stoffwechsel aller Zellen ein, von klinischer Seite stehen die Funktionsstörungen des zentralen Nervensystems, der Leber, der Nieren und des Herzens im Vordergrund. Der Tod tritt meistens durch ein Versagen der Leber oder des zentralen Nervensystems ein. Wir berichten über den tödlichen Verlauf einer suizidalen EDC-Vergiftung bei einem jungen Mann. Er war 30 Minuten nach der Einnahme von 125 ml EDC auf der Notfallaufnahme eingetroffen. Er wurde sofort intubiert, eine Darmlavage unter Applikation von Aktivkohle begonnen. Es kam in kurzer Folge zu einem fulminanten Kreislaufversagen mit einer schweren metabolischen Acidose, schließlich zum Herzkreislaufstillstand. Mit dem Einsatz der perkutan implantierbaren Herzlungenmaschine (pHLM) konnte eine kurzfristige Besserung der Metabolik erreicht werden. Trotz des extrakorporalen Kreislaufs traten Muskelkontrakturen wie bei der Totenstarre auf. Bei persistierender Asystolie wurde der extrakorporale Kreislauf beendet.
    Notes: Summary Ethylene dichloride (EDC) is used as a solvent and in the rubber, plastic, and insecticide industry. The fatal adult dose is below 20 ml. Poisoning can occur from inhalation, ingestion or skin absorption. EDC depresses almost all cells, but essentially those of the central nervous system, liver, kidneys, and heart. Death is usually due to liver or central nervous failure. We report the lethal suicidal EDC poisoning in a young patient. The patient arrived in hospital 30 minutes after ingestion of 125 ml of EDC. He was intubated immediately; intestinal lavage with charcoal was installed. Fulminant cardiac failure and severe acidosis lead to cardiac arrest; treatment with the percutaneous cardiopulmonary bypass was started. A short period of metabolic improvement was followed by muscle contractures mimicking cadaverick rigidity, asystoly persisted, and the extracorporeal therapy was terminated.
    Type of Medium: Electronic Resource
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