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  • 1
    ISSN: 1432-1440
    Keywords: Physical exercise ; Emotional stress test ; Blood pressure reactivity ; Hypertension ; Physische Belastung ; Emotioneller ; Streßtest ; Blutdruckreaktivität ; Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Zusammenhang zwischen den Blutdruckreaktionen auf eine ergometrische und eine emotionelle Streßbelastung wurde bei 62 normotonen Probanden untersucht. Es wurden für systolischen (r=0,34,p=0,004) und diastolischen (r=0,30,p=0,01) Blutdruck signifikante Korrelationen gefunden. Es wurde geschlossen 1) daß es eine individualspezifische Blutdruckreagibilität gibt, 2) daß Hypertonie eng mit der individualspezifischen systolischen Blutdruckreaktivität zusammenhängt, da bekannt ist, daß Hypertoniker auf beide Stressoren eine stärkere systolische Blutdruckreaktivität aufweisen.
    Notes: Summary The relationship between blood pressure reactions on an ergometric and an emotional stress test was studied in a population of 62 normotensive subjects. Significant correlations for systolic (r=0.34,p=0.004) and diastolic (r=0.30,p=0.01) blood pressure were found. It is concluded that 1) there is a individual-specific blood pressure reactivity, 2) Hypertension is closely related to the individualspecific systolic blood pressure reactivity for it is known that hypertensives exhibit stronger systolic blood pressure reactions on both stressors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 63 (1985), S. 93-94 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 40 (1991), S. 67-70 
    ISSN: 1432-1041
    Keywords: Dilevalol ; oxprenolol ; hypertension ; emotional stress ; haemodynamic changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a single dose of 200 mg dilevalol, β-adrenoceptor blocker with additional vasodilating properties, and 200 mg oxprenolol on haemodynamic changes induced by emotional stress have been compared in 12 male young Caucasian patients with newly diagnosed labile hypertension. No difference was noted in the stress-induced increase of total peripheral resistance (TPR) following administration of the two substances (11% versus 6%). However, dilevalol revealed a vasodilating action by decreasing TPR at rest (from 1004 to 951 dyn·s·cm−5) and diastolic blood pressure (BP) (from 87 to 75 mm Hg) whereas TPR at rest remained unchanged after the intake of oxprenolol.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 47 (1980), S. 9-19 
    ISSN: 1432-1246
    Keywords: Noise ; Finger pulse amplitude ; Blood pressure ; Heart rate ; Lärm ; Fingerpulsamplitude ; Blutdruck ; Herzfrequenz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Dreiundvierzig Versuchspersonen (30 Männer und 13 Frauen) wurden mit Verkehrslärm von ca. 72 dB (A) belastet. Ihre Reaktionen in Blutdruck, Blutdruck-, Fingerpuls- und Radialispulsamplitude, Herzfrequenz, Atemfrequenz and Myointegral wurden untersucht. 2. Jeder Kreislaufparameter zeigte in über 40% der Versuchspersonen signifikante Reaktionen in unterschiedlicher Richtung. Am deutlichsten war dabei ein Trend der Fingerpulsamplitude zur Verengung erkennbar. Blut druck- und Radialispulsamplitude sowie Herzfrequenz neigten ebenfalls zum Abfall, der diastolische Blutdruck zum Anstieg. Demgegenüber blieben Atemfrequenz und Myointegral weitgehend unverändert. 3. Die unterschiedliche Richtung der Reaktionen läßt Mittelwertbildungen im Kollektiv als potentiell irreführend erscheinen. Weiterhin wird vorgeschlagen, die Fingerpulsreaktion auf die Standardabweichung der Vorruhe statt auf den Mittelwert der Vorruhe zu beziehen. 4. Männer reagieren mit stärkeren Herzfrequenzabfällen als Frauen. Innerhalb der Männer zeigten Fingerpulsamplitude und Herzfrequenz bei erhöhten diastolischen Gelegenheitsblutdruckwerten und -herzfrequenzen stär kere Abnahmen. Ältere Männer reagieren eher mit Herzfrequenzanstiegen. 5. Innerhalb der Männer korrelierte die Fingerpulsamplitude positiv mit der Reaktion von Blutdruckamplitude und Herzfrequenz, nicht aber mit der der Radialispulsamplitude. Der Versuch, mit Hilfe der Radialispulsamplitude vasoaktive und druckpassive Anteile der Fingerpulsamplitude zu trennen, zeigte keine befriedigenden Ergebnisse. Ursache ist vermutlich eine starke Artefaktanfälligkeit der Radial ispulsamplitude. 6. Die dargestellten Ergebnisse stützen die Hypothese, daß Gegenregulationen die Reaktionen auf Dauerlärm beeinflussen. Bei gleichzeitiger sympathischer und parasympathischer Erregung kommt es zu keiner nennenswerten Blutdruckerhöhung.
    Notes: Summary 1. Forty-three (30 male and 13 female) subjects were exposed to traffic noise of ca. 72 dB. Their reactions concerning blood pressure, pulse pressure, finger pulse amplitude and radialis pulse amplitude, heart rate, breathing rate, and integrated EMG were analyzed. 2. Each of the circulatory parameters exhibited significant reactions in either direction in more than 40% of the subjects. The vasoconstrictive reaction in finger pulse amplitude was most outstanding. Moreover, pulse pressure, radialis pulse amplitude and, heart rate also tended to decrease whereas diastolic blood pressure tended to increase. Breathing rate and EMG remained mainly unchanged. 3. Owing to the different direction of reactions the mean values of a sample can yield possibly misleading information. Furthermore, it is suggested that the reaction of finger pulse amplitude should be related to the standard deviation of the prestimulus resting period instead of to the mean value of this period. 4. Male subjects react with a stronger decrease of heart rate than female subjects. Male subjects with higher diastolic casual blood pressure and heart rate values exhibit stronger decreases in finger pulse amplitude and heart rate. Older male subjects tend to react with an increase of heart rate. 5. Within the male subjects, the reaction of finger pulse amplitude correlated positively with the reactions of pulse pressure and heart rate, but not with the reaction of radialis pulse amplitude. The attempt to distinguish between vasoactive and pressure-dependent components in finger pulse amplitude means of radialis pulse amplitude failed, which is probably a consequence of artifacts in radialis pulse amplitude. 6. These results confirm the hypotheses that compensatory mechanisms influence the reactions caused by noise. There is no essential increase in blood pressure, sympathetic and parasympathetic activity being simultaneously increased.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 1315-1316 
    ISSN: 1432-1440
    Keywords: Type-A behaviour pattern ; Coronary heart disease ; β-Blockers ; Blood pressure reactivity ; Hypertension ; Typ-A-Interview ; koronare Herzerkrankung ; β-Blocker ; Blutdruckreaktivität ; Hypertonie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung koronargefährdender Verhaltensweisen (Typ-A-Verhalten) für die koronare Herzerkrankung ist bekannt. Eineβ-sympathomimetische Übererregbarkeit bei Typ-A-Personen wird vermutet, wenn auch der pathophysiologische Mechanismus noch nicht vollständig geklärt wurde. Bei der jetzigen Untersuchung wurde der Einfluß vonβ-Blockern auf das Typ-A-Verhalten in einem interindividuellen Vergleich gemessen. 16 männliche Hypertoniker wurden randomisiert in 2 Therapiegruppen (β-Blocker und Diuretika) aufgeteilt. Das Typ-A-Interview wurde bei jedem Patienten einmal vor Therapie durchgeführt und frühestens 4 Wochen nach Therapiebeginn wiederholt. Bezüglich Alter, Ruheblutdruck, kardiovaskulärer Reaktivität und Typ-A-Verhalten vor Therapie zeigten sich zwischen diesen beiden Gruppen keine Unterschiede. Nach Therapie waren bei der Gruppe, die mitβ-Blockern behandelt wurde, die Typ-A-Verhaltensweisen im Vergleich zu der Gruppe, die mit Diuretika behandelt wurde, geringer ausgeprägt. Die klinische Bedeutung dieser Ergebnisse im Hinblick auf die koronare Herzerkrankung muß in einer prospektiven Studie geklärt werden.
    Notes: Summary The influence of coronary-prone behaviour on coronary heart disease is well established, but the link between behavioural and pathophysiological processes is still unknown. Aβ-adrenergic hyper-reactivity of type-A subjects is assumed. In this investigation the influence ofβ-blockers on the type-A behaviour pattern was tested in an inter-individual comparison. Sixteen male hypertensive subjects (stage I or II) were divided at random into two therapeutic groups (β-blockers vs diuretics). Each patient was given a type-A interview before therapy and at a minimum of 4 weeks after the onset of therapy. Subjects in both groups were similar in age and before therapy they had similar blood pressure at rest as well as similar cardiovascular reactivity and type-A behaviour pattern. After therapy, subjects in the group treated withβ-blockers exhibited less type-A behaviour than those in the group treated with diuretics. The possible influence of the attenuation of the type-A behaviour on the risk of coronary heart disease should be investigated in a prospective study.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 68 (1990), S. 256-262 
    ISSN: 1432-1440
    Keywords: Microproteinuria ; Essential hypertension ; Nephropathy ; Left ventricular hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the clinical importance of microproteinuria, we examined the prevalence of microproteinuria and its relation to cardiac structural adaptation in 80 male, middle-aged patients with essential hypertension. Patients with secondary causes of hypertension were ruled out. 14 out of 80 hypertensives (18 percent) were found to have microproteinuria defined as “negative” for urinary protein excretion in the conventional test, but “positive” (above the upper normal limit) in the 24-hour urine samples. Patients with microproteinuria had a similar age and body weight, but a higher systolic and diastolic pressure (161±14/104±12 vs 148±14/97±9 mmHg,p〈 0.02) and greater creatinine clearance (163±36 vs 136±33 ml/min,p〈0.01) than those with normal protein excretion. Also, hypertensives with microproteinuria had a greater left ventricular mass (241±57 vs 207±45 g,p〈0.05) and greater cross sectional area (22.2±2.8 vs 20.5±2.9 cm2,p〈 0.05) evaluated by 2-D guided M-mode echocardiography than the control group. A positive Sokolow-index was more prevalent in patients with microproteinuria than in those without (x 2=6.2,p〈0.02). Patients with essential hypertension and microproteinuria (prevalence 21 per cent) were characterized by a higher arterial pressure, by a higher degree of echocardiographic and electrographic evidence of left ventricular hypertrophy. Thus, microproteinuria might serve as a marker for early target organ damage in essential hypertension.
    Type of Medium: Electronic Resource
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