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  • 1
    Electronic Resource
    Electronic Resource
    Factors predicting the therapeutic outcome of duodenal ulcer treatment with H2-receptor antagonists (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 1152-1159 
    Details
    ISSN: 1432-1440
    Keywords: Duodenal ulcer healing ; Acid secretion ; Cimetidine pharmacokinetics ; Treatment response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective trial 37 duodenal ulcer patients were treated daily with 1 g cimetidine. Personal and clinical data were obtained for all patients, acid secretion studies performed before and during treatment, and pharmacokinetic parameters of cimetidine determined. The healing rate after 4 weeks was 64.9% (24 patients). Non-Responders included a higher proportion of smokers, patients with a history of ulcer and previous treatment with H2-receptor antagonists than Responders. Basal acid output (BAO) and peak acid output (PAO) values were not different between the two groups, nor was the reduction of BAO and PAO under cimetidine. However, more Responders had complete suppression of BAO than Non-Responders. A correlation existed in both groups between cimetidine plasma concentration and PAO suppression but not with BAO suppression. Regular drug intake (compliance) was found in about 90% in both groups. Cimetidine bioavailability parameters were identical in both groups, but Non-Responders had a higher peak concentration and a shorter time of peak concentration. Discriminant analysis enabled a prediction of treatment response in 89.2% of the patients by using five factors: time of peak concentration of cimetidine, previous H2-receptorantagonist treatment, peak concentration, smoking, and alcohol use. Prediction of treatment response is increased by use of drug related variables.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01740590
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ein Beitrag zum Pseudo-LE-Syndrom (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 755-763 
    Details
    ISSN: 1432-1440
    Keywords: Autoimmune diseases ; Autoantibodies ; Drugs ; Systemic lupus erythematosus ; Autoimmunerkrankung ; Autoantikörper ; Medikamente ; Lupus erythematodes disseminatus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 30 Patienten mit Pseudo-LE-Syndrome wiesen im akuten Schub der Erkrankung 13 eine meist reversible Herzvergrößerung auf. Bei zwei Patienten hatte die im Rahmen der Erkrankung Über Jahre dauernde Carditis zur klinisch manifesten Herzinsuffizienz geführt und ein weiterer Patient war im akuten Stadium an der Carditis verstorben. Im Gegensatz zum Lupus erythematodes disseminatus wurde eine Hypertonie nicht gehäuft beobachtet. Rechtsherzkatheteruntersuchungen an 5 Patienten zeigten durchgehend geringgradige Erhöhungen des enddiastolischen Druckes im rechten Ventrikel und bei je zwei Patienten einen erhöhten Mitteldruck im rechten Vorhof und einen systolischen Druckgradienten über der Pulmonalis. — Szintigraphisch wurden teilweise deutliche Milzvergrößerungen und geringgradige Lebervergrößerungen nachgewiesen. Laparoskopisch fanden sich nach abgelaufener Peritonitis ausgedehnte Verwachsungen. — Lymphographisch konnten Veränderungen an den retroperitonealen Lymphknoten und Lymphbahnen im Gegensatz zu anderen rheumatischen Erkrankungen nicht festgestellt werden. — Arzneimittelanamnesen deckten in den meisten Fällen eine Einnahme von Venopyronum® Dragees vor Erkrankungsbeginn auf, doch kam es auch zum Auftreten neuer Krankheitsschübe, ohne daß jeweils das Medikament zuvor erneut eingenommen worden war.
    Notes: Summary 13 of 30 patients suffering from pseudo-LE-syndrome showed a usually reversible enlargement of the heart during the acute stage of the disease. In two patients carditis occurring in pseudo-LE-syndrome lead to congestive heart failure and an additional patient died in the acute stage of carditis. As opposed to Systemic Lupus Erythematosus hypertension did not occur in a higher frequency than normal. In five cases cardiac catheter examinations showed slight elevation of the end-diastolic pressure in the right ventricle, in two cases an abnormal high mean pressure in the right atrium and a systolic gradient at the pulmonic valve was found. — Scintigrams showed definite enlargement of the spleen and to a lesser degree enlargement of the liver was seen. Laparascopy showed multiple concretions after peritonitis. Lymphographic changes in the retroperitoneal lymph nodes and lymphatic ducts were not observed in contrast to rheumatic diseases. Drug histories in most cases discovered intake of Venopyronum® dragees prior to onset of the disease. But recurrent attacks of the disease also occurred without further intake of the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614292
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acute arterial occlusions due to accidental intra-arterial injections of diazepam (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 93-94 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733075
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of pantoprazole versus omeprazole in the treatment of acute duodenal ulceration—a multicentre study (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 9 (1995), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Methods: In this randomized, double-blind, multicentre study, the proton pump inhibitors pantoprazole and omeprazole were compared in patients with active duodenal ulcers. Two hundred and seventy-six protocol-correct patients received either pantoprazole 40 mg (n= 185) or omeprazole 20 mg (n= 91), once daily for 2 or 4 weeks, depending on the progress of ulcer healing. Results: Rates of complete ulcer healing after 2 weeks were 71% in patients given pantoprazole and 74% in patients given omeprazole. After 4 weeks the figures were 96% and 91%, respectively. These differences were not significant. There was no significant difference in ulcer pain prior to treatment, and 85% of the pantoprazole group and 86% on omeprazole were pain-free after 2 weeks (not significant). The time until complete pain relief with pantoprazole or omeprazole, based on data from diary cards, was not significantly different (P 〈 0.05, Uleman's U-test). Both treatments were equally well tolerated. Changes in routine laboratory parameters were minimal in both groups. Conclusion: Pantoprazole was shown to be a highly-effective and well-tolerated treatment for acute duodenal ulcer. Pantoprazole 40 mg and omeprazole 20 mg were equally effective with respect to ulcer healing and pain relief, and have similar adverse event profiles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1995.tb00399.x
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    Paper (German National Licenses)
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