ISSN:
1432-1459
Keywords:
Key words Parkinson’s disease
;
Parkinsonism
;
Genetic susceptibility
;
α-Synuclein
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The finding of a mutation in the α-synuclein gene in a rare autosomal dominant form of idiopathic Parkinson’s disease (IPD), has prompted increased interest in identifying genes that account for the more common sporadic form. A number of association studies have suggested that functional polymorphisms in genes that play a role in dopamine, drug and toxin metabolism may increase the relative risk of IPD. Unfortunately, patient numbers are often small, and the results have not been consistently reproduced. This article reviews the evidence from epidemiological, imaging and genetic studies to determine the role of genetic susceptibility in IPD and parkinsonian syndromes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004150050258
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