ISSN:
1573-7373
Keywords:
leptomeningeal metastasis
;
B16 melanoma
;
magnetic resonance imaging
;
animal model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract MR imaging of the rat brain has become an increasingly frequently used method in experimental neuroradiology. On a generally available 1.5 T whole body tomograph, supplemented with an individually made small coil and a special SE sequence we obtained fairly fine images of the structures of the rat brain. With gadolinium-DTPA, we were able to visualize posterior fossa and cervical leptomeningeal growth of intrathecally injected B16 melanoma in nude rats. Using MRI to follow experimental leptomeningeal metastasis, may provide a new means for diagnostic evaluation and preclinical testing of treatment modalities.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00172596
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