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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 5 (1978), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1.The angiotensin II antagonist, 1-Sar-8-Ala-angiotensin II (saralasin), was infused intravenously at a rate of 10 μg/kg per min in thirty-three hypertensive patients, on a normal sodium diet (130 mmol per day) and/or during sodium depletion by low sodium diet (20 mmol per day) and chlorthalidone.2. In both series, saralasin induced a transient rise in intra-arterial pressure (P 〈 0.01), accompanied by a slight decrease in heart rate (P 〈 0.01). The elevation of systolic arterial pressure reached its maximum after 4 min and was more pronounced in sodium-replete patients. Plasma noradrenaline was significantly elevated by 29.7% (P〈0.01), but the rise in pressure was not related to concomitant changes in plasma noradrenaline.3. After the initial pressor effect, arterial pressure, heart rate, cardiac output and total peripheral resistance remained unchanged in the sodium-replete patients, while in the sodium-depleted conditions mean arterial pressure and peripheral resistance were reduced, by 17.8% and 18.6% (P〈 0.001) respectively, within 60min. Reflex increases in heart rate (+3.8%) and cardiac output (+ 11.1%) occurred after 10 min (P〈0.05), but were not sustained thereafter.4. Pulmonary vascular resistance was not affected by saralasin. In sodium-depleted patients, pulmonary capillary wedge pressure decreased by 1.2mmHg (P〈0.01), with parallel changes of pulmonary artery pressure (P〈 0.01).
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1076
    Keywords: Exercise testing ; Congenital heart disease ; Acrobic capacity ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aerobic capacity of patients with different forms of congenital heart disease was serially evaluated in 79 patients and the evolution was correlated with the lesion and the level of daily activity. The patients were divided into six groups: patients with a small ventricular septal defect (VSD) with mini shunt (n=14), mild pulmonary valve stenosis with gradient 〈40 mm Hg (PS) (n=12), mild to moderate aortic valve stenosis (gradient 36±17 mm Hg) (AS) (n=12), patients 4.7±2.1 years after repair of tetralogy of Fallot (PO-TF) (n=16), patients 2.2±2.9 years after closure of a high flow/high gradient VSD (PO-VSD) (n=13), and patients 2.6±1.7 years after Fontan repair (Fontan-PO) (n=12). Aerobic capacity was assessed by determination of the ventilatory anaerobic threshold (VAT). VAT reflects the highest aerobic exercise level prior to a disproportionate increase of CO2 and ventilation relative to O2 uptake; it is independent of patient motivation. Data are expressed as percentage of normal O2 uptake at VAT, determined in 234 age/gender matched controls. The habitual level of physical activity was assessed by a standardised questionnaire. Aerobic capacity in all subgroups of patients, even with very mild defects, was at or below the lower limit of normal. Children left unrestricted from physical exercise (VSD, PS, PO-VSD) had no change over the study period. However, aerobic capacity of patients with medically imposed physical restrictions (AS) and significant residual haemodynamic lesions (PO-TF, Fontan) decreased with age. In patients with AS, PO-TF and Fontan-PO the habitual level of physical activity was significantly decreased compared to controls. Conclusion Cardiovascular exercise performance in children with medically imposed restriction of intensive physical exercise (AS) or residual haemodynamic lesions (TF and Fontan-PO) declines progressively during medium-term follow up. In the other patient groups (VSD, PS, VSD-PO), exercise performance remains stable.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 10 (1976), S. 297-303 
    ISSN: 1432-1041
    Keywords: Hypertension ; beta-blockers ; atenolol ; propranolol ; isoprenaline-tachycardia ; exercise tachycardia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The comparative potency of two beta-blockers, propranolol and atenolol, in the inhibition of exercise tachycardia and isoproterenol-tachycardia has been studied in two groups of hypertensive patients, using oral doses which were increased weekly. A linear correlation was observed between the reduction in exercise tachycardia and the dose of each drug, up to a daily dose of propranolol 480 mg and atenolol 600 mg. Propranolol was slightly (0.7/1) more potent in decreasing maximal exercise tachycardia than atenolol when tested in low doses (below 100 mg); at higher doses (480 mg) no differences were found. However, atenolol was 10 times less potent than propranolol in blocking isoprenaline-induced tachycardia, which seems to be related to the cardioselectivity of atenolol.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: Bunitrolol ; β-blockade ; partial agonist ; haemodynamic response ; exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of chronic beta blockade on the haemodynamic response to graded exercise was studied in 18 hypertensive patients treated with bunitrolol, which has partial agonist activity. The patients first received a placebo for 5 to 12 days, then bunitrolol 30 mg daily for one week and subsequently the dose was doubled weekly as necessary upto 240 mg daily. At rest haemodynamic changes after beta blockade were only minor; heart rate decreased by 8% and no significant change was observed in stroke index, cardiac index, (a-v)O2 difference and VO2. The hypotensive effect was not significant and no significant change in mean pulmonary arterial and wedge pressure was observed. Maximal exercise capacity remained unchanged, because of haemodynamic responses. The maximal exercise heart rate was reduced by 25% during beta blockade, which was compensated by a 34% elevation in stroke index, whereas maximal cardiac index and (a-v)O2 difference remained unchanged. There was no consistent change in mean pulmonary artery pressure during maximal exercise, but the mean brachial artery pressure fell by 12%.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1041
    Keywords: Hypertension ; low sodium diet ; angiotensin antagonist ; plasma renin ; chlorthalidone ; hypotensive effect ; sodium depletion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypotensive effect of acute sodium volume depletion, produced by chlorthalidone and a low sodium diet, was inversely related to the plasma renin concentration (PRC) in 13 hypertensive patients of varying aetiology (r=0.61; p〈0.05); weight reduction induced by this therapy was not related to PRC (r=0.12; p〉0.1). The angiotensin II antagonist 1-sar-8-ala-angiotensin II failed to reduce arterial pressure when the patients ingested 130 mEq sodium per day, but pressure fell when it was infused during sodium volume depletion, except when PRC remained low; the changes in pressure were related to the plasma renin level (r=0.78; p〈0.005). The combined hypotensive response to acute sodium volume depletion and to angiotensin II blockade during sodium volume depletion was not related to PRC (r=0.15; p〉0.1). The results demonstrate that acute sodium volume depletion caused similar weight loss in patients with high and low PRC values, and it would have had similar hypotensive effects but for angiotensin-induced vasoconstriction in the high renin patients. Since 1-sar-8-ala-angiotensin II also reduced arterial pressure in 6 patients during chronic diuretic therapy, angiotensin II must still induce vasoconstriction in these circumstances.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 54 (1985), S. 278-284 
    ISSN: 1439-6327
    Keywords: Exercise ; Children ; Anaerobic threshold ; Anaerobic metabolism ; Performance capacity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ventilatory anaerobic threshold (VAT) during graded exercise was defined as the oxygen uptake ( $$\dot V_{{\text{O}}_{\text{2}} }$$ ) immediately below the exercise intensity at which pulmonary ventilation increased disproportionally relative to $$\dot V_{{\text{O}}_{\text{2}} }$$ . Since VAT is considered to be a sensitive and noninvasive measure for evaluating cardiorespiratoy endurance performance, the purpose of the present study was to determine normal values in children. We examined 257 healthy children (140 boys and 117 girls) varying in age from 5.7 to 18.5 years, during treadmill exercise. The data were analyzed in relation to sex and age. In boys the lowest $$\dot V_{{\text{O}}_{{\text{2max}}} }$$ (ml · min−1 · kg−1) was found in the youngest age group (5–6 year). In girls, on the other hand, no significant increase occurred with age. For VAT, expressed as ml O2 · min−1 · kg−1 or as a percent of $$\dot V_{{\text{O}}_{{\text{2max}}} }$$ a significant decrease was found in boys and girls with age. This suggests an increase in lactacid anaerobic capacity during growth. In contrast to observations in adults, only low correlations were found between $$\dot V_{{\text{O}}_{{\text{2max}}} }$$ and VAT (r=0.28 in boys and r=0.52 in girls), which suggests that the development of the underlying physiological mechanism does not occur at the same rate in growing children. These data provide normal values for VAT that can be used for clinical exercise testing in the pediatric age group.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 58 (1989), S. 803-807 
    ISSN: 1439-6327
    Keywords: Children ; Exercise ; Physical activity ; Endurance ; Performance ; Ventilatory threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 257 healthy children (140 boys, 117 girls) varying in age from 5.7 to 18.5 years underwent graded exercise tests on a treadmill. Cardiorespiratory endurance capacity was assessed by determination of the ventilatory threshold, which was defined as the highest exercise intensity before a disproportionate increase occurred in pulmonary ventilation ( $$\dot V$$ E) relative to oxygen uptake ( $$\dot V_{o_2 } $$ ). The purpose of the present study was to investigate the relationship between the habitual level of physical activity (HLPA) and the cardiorespiratory endurance capacity in children. The HLPA was assessed by a standardized questionnaire. In boys and girls HLPA increased gradually with advancing age. For the group as a whole, the boys reached the highest values for HLPA. The most active boys reached the highest value for ventilatory threshold and the lowest value was found in the less active ones, except for the age span of 12–16 years. It is concluded that more active boys showed a higher cardiorespiratory endurance capacity, as assessed by the ventilatory threshold, compared to less active ones, except during puberty. It can be postulated that during puberty this effect may be overruled by the influence of other more dominant growth-related factors. In girls, because HLPA was rather low, there was no discriminative effect of HLPA on exercise performance, as would be expected.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of applied physiology 50 (1982), S. 79-85 
    ISSN: 1439-6327
    Keywords: Exercise ; Anaerobic threshold ; Children ; Physical working capacity ; Anaerobic metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cardiorespiratory response to graded treadmill exercise was studied in a group of kindergarten children, aged 5 to 6 years. From the non-linear change of pulmonary ventilation with increasing exercise intensity a “ventilatory threshold” was determined which averaged 28.1±4.9 (SD) ml O2·min−1·kg−1. A significant correlation was established between this ventilatory threshold (ml O2·min−1) and the physical working capacity at a heart rate of 170 beats per min (PWC170, ml O2·min−1):r=0.93,p〈0.001. These data show that a ventilatory threshold can be obtained in young children which is an objective index of cardiorespiratory performance capacity.
    Type of Medium: Electronic Resource
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