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  • 1
    Electronic Resource
    Electronic Resource
    Modulation of Bone Resorption by Tetracyclines (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 732 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb24733.x
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of indomethacin on alveolar bone loss in experimental periodontitis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 17 (1982), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was undertaken to determine if prostaglandins play a role in the events leading to loss of bone in the ligature model of periodontitis. Periodontitis was induced by placement of the ligatures around mandibular teeth on one side of the jaw of squirrel monkeys (Saimiri sciureus). From one day prior to ligature placement, half the animals were administered indomethacin (5 mg/kg/day), a potent inhibitor of prostaglandin synthesis. Animals were sacrificed after one and two weeks of experimental periodontitis. It was found that indomethacin treatment abolished the significant losses of alveolar bone height and bone mass seen in non-indomethacin-treated (NIT) animals following ligature placement. Indomethacin also depressed the large increase in osteoclast density measured at one week in the NIT animals. The results support the hypothesis that prostaglandins are an important mediator of bone loss in the ligature model of periodontitis. Evidence is also presented for the coupling of bone resorption with osteoblastic neo-osteogenesis on both periodontal ligament and endosteal bone surfaces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1982.tb01134.x
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  • 3
    Electronic Resource
    Electronic Resource
    The nuclear fibrous lamina of alveolar bone cells (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 14 (1979), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The nuclear fibrous lamina, a structure of unknown composition and function, is described in alveolar bone cells of squirrel monkeys. Osteoblasts, osteocytes, and osteoprogenitor cells contain nuclear envelopes with prominent fibrous laminas measuring up to 800° A. in width, while osteoclasts have nuclei with poorly developed laminas. The fibrous lamina is an amorphous or fine-textures, moderaly electron dense layer directly applied on its external surface to the inner nuclear membrane. Its interior surface is bordered by beads of heterochromatin. At nuclear pore sites the lamina is either absent or markedly attenuated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1979.tb00782.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Fine structure of fetal rat calvarium; provisional identification of preosteoclasts (1980)
    Springer
    Calcified tissue international 31 (1980), S. 21-28 
    Details
    ISSN: 1432-0827
    Keywords: Rat ; Calvarium ; Electron microscopy ; Preosteoclasts ; Osteoclasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary This is a study of the fine structure of cells of the 20-day fetal rat calvarium. Special attention is given to identifying and characterizing preosteoclasts. These cells are relatively common and located largely, but not exclusively, at the endocranial bone surface. The preosteoclasts are characterized by abundant mitochondria, an incomplete perinuclear Golgi apparatus, and variable-shaped dense granules. The dense granules are unique in appearance in that they contain an internal dense matrix surrounded by a clear halo. Most granules are circular in shape but some are elongate or tubular in form. Granules with identical appearance are observed in osteoclasts. The preosteoclasts are mononucleate, or occasionally binucleate. It is suggested that because preosteoclasts are morphologically distinctive and relatively abundant, it should be feasible to separate these cells from a heterogeneous cell isolate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02407163
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  • 5
    Electronic Resource
    Electronic Resource
    Tetracyclines modulate cytosolic Ca2+ responses in the osteoclast associated with “Ca2+ receptor” activation (1993)
    Springer
    Bioscience reports 13 (1993), S. 169-174 
    Details
    ISSN: 1573-4935
    Keywords: tetracycline ; osteoclasts ; cytosolic Ca2+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We report the effects of tetracycline analogues on cytosolic Ca2+ transients resulting from application of ionic nickel (Ni2+), a potent surrogate agonist of the osteoclast Ca2+ “receptor”. Preincubation with minocycline (1 mg/l) or a chemically modified tetracycline, 4-dedimethyl-aminotetracycline (CMT-1) (1 or 10 mg/l), resulted in a significant attenuation of the magnitude of the cytosolic [Ca2+] response to an application of 5 mM-[Ni2+]. Preincubation with doxycycline (1 or 10 mg/l) failed to produce similar results. In addition, application of minocycline alone (0.1–100 mg/l) resulted in a 3.5-fold elevation of cytosolic [Ca2+]. The results suggest a novel action of tetracyclines on the osteoclast Ca2+ “receptor”.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01149961
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of tetracyclines on quantitative measures of osteoclast morphology (1993)
    Springer
    Bioscience reports 13 (1993), S. 175-182 
    Details
    ISSN: 1573-4935
    Keywords: tetracyclines ; 4-dedimethylaminotetracycline ; osteoclastic resorption ; osteoclast Ca2+ receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We report the effects of the tetracycline analogues 4-dedimethylaminotetracycline (CMT-1) and minocycline on osteoclast spreading and motility. Both agents influenced the morphometric descriptor of cell spread area, ϱ, producting cellular retraction or an R effect (half-times: 30 and 44 minutes for CMT-1 and minocycline, respectively). At the concentrations employed, the tetracycline-induced R effects were significantly slower than, but were qualitatively similar to, those resulting from Ca2+ “receptor” activation through the application of 15 mM-[Ca2+] (slopes: −1.25, −0.18, and −4.40/minute for 10 mg/l-[CMT-1], 10 mg/l-[minocycline] and 15 mM-[Ca2+], respectively). In contrast, the same tetracycline concentrations did not influence osteoclast margin ruffling activity as described by μ, a motility descriptor known to be influenced by elevations of cellular cyclic AMP. Thus, the tetracyclines exert morphometric effects comparable to changes selectively activated by occupancy of the osteoclast Ca2+ “receptor” which may act through an increase in cytosolic [Ca2+].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01149962
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  • 7
    Electronic Resource
    Electronic Resource
    An ultrastructural study of macrophage-mediated resorption of calcified tissue (1979)
    Springer
    Cell & tissue research 202 (1979), S. 125-132 
    Details
    ISSN: 1432-0878
    Keywords: Macrophage ; Osteoclast ; Bone resorption ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ultrastructural observations on macrophage-mediated resorption of calcified tissue of killed fetal long bones are described and correlated with increased 45Ca release into the medium. Macrophages disrupt calcified tissue extracellularly and appear to engulf large fragments of mineralized matrix. Ruffled borders, which are common features of osteoclasts at sites of resorption of bone, do not develop in macrophages. However, clear zones are seen in macrophages as well as osteoclasts. These findings provide additional evidence for non-osteoclast-mediated resorption of calcified tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239225
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of prostaglandin E2 on macrophages and osteoclasts in cultured fetal long bones (1980)
    Springer
    Cell & tissue research 207 (1980), S. 341-346 
    Details
    ISSN: 1432-0878
    Keywords: Macrophage ; Osteoclast ; Prostaglandin ; Bone resorption ; Organ culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Bone cultures exposed to prostaglandin E2 (PGE2) revealed an increase in 45Ca release from bone to medium and an increase in osteoclast number compared to control bones. In addition, PGE2-treated osteoclasts contained a more extensive ruffled border region than control osteoclasts. These data suggest that PGE2 activates existing osteoclasts and causes proliferation and differentiation of osteoclast precursor cells. The existence of macrophages in resorbing fetal bone explants was documented. These macrophages contain numerous phagolysosomes and lipid vacuoles and are often located adjacent to osteoclasts or closely apposed to calcified tissue surfaces. PGE2 caused an early increase in the number of macrophages. It is postulated that fetal bone macrophages are primarily engaged in phagocytosis and digestion of cellular debris, but also play a role in the process of bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237817
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  • 9
    Electronic Resource
    Electronic Resource
    Osteoid resorption by mononuclear cells in vitro (1980)
    Springer
    Cell & tissue research 210 (1980), S. 493-500 
    Details
    ISSN: 1432-0878
    Keywords: Mononuclear cell ; Organ culture ; Osteoid ; Bone resorption ; Macrophage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary For the first time, mononuclear cell-mediated ingestion of osteoid in cultures of long bones of fetal rats is described and characterized. The mononuclear cells, located at sites of osteoid deposition, ingest collagen fibrils and clumps of mineral crystals which are segregated within cytoplasmic vacuoles or multivesicular bodies. The ingestion of osteoid continues in cultures treated with agents that normally inhibit osteoclastic bone resorption. Morphologically, the osteoid-containing cells are characterized by a moderate number of mitochondria and short-stranded rough endoplasmic reticulum, a modest Golgi apparatus and variable numbers of vesicles, vacuoles, and multivesicular bodies. The morphologic appearance of the mononuclear cell is consistent with that of a macrophage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220205
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