ISSN:
1432-1238
Keywords:
Key words Toxic shock syndrome
;
Urokinase-type plasminogen activator
;
Tissue-type plasminogen activator
;
Acute respiratory distress syndrome
;
Acute renal failure
;
Plasminogen activator inhibitor-1
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: Definition of the changes in the activators of plasminogen, u-PA and t-PA, and examination of the possible generation of plasmin in the circulation in overwhelming sepsis. Design: Serial blood analysis starting 4 h after development of symptoms of toxic shock syndrome. Setting: Intensive care unit. Patient: A previously healthy woman underwent endometrial ablation and rapidly thereafter developed staphylococcal toxic shock syndrome with organ failure. Measurement and result: t-PA, PAI-1, t-PA-PAI-1 complexes, plasminogen, fibrinogen and plasmin-α2-antiplasmin complexes were measured serially by ELISA and free u-PA by SDS-PAGE with zymography. The onset of symptoms was accompanied by a rise of t-PA antigen followed rapidly by PAI-1 antigen. Plasmin-α2-antiplasmin complex was generated in large amounts but disappeared within hours. From day 3, free u-PA was detectable in the circulation without plasmin generation. Conclusion: Despite the sustained presence of active u-PA in the circulation and of t-PA antigen at the onset of symptoms, plasmin-α2-antiplasmin generation was largely suppressed by high levels of PAI-1. The suppression of plasmin generation by u-PA and t-PA may ensure the persistence of fibrin in the microcirculation and so contribute to organ failure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001340050561
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