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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and Rates of Acetolysis of exo-exo and exo-endo-Tricyclo[3.2.1.02,4]octan-6-yl p-Bromobenzenesulfonates1,2 (1965)
    s.l. : American Chemical Society
    The @journal of organic chemistry 30 (1965), S. 2462-2464 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01018a509
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  • 2
    Electronic Resource
    Electronic Resource
    Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 92 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have previously identified an increased susceptibility of glutathione peroxidase-1 (Gpx1)–/– mice to neuronal apoptosis following mid-cerebral artery (MCA) occlusion. This study was designed to elucidate the mechanisms involved in elevated neuronal cell death arising from an altered endogenous oxidant state. This was addressed in both an in vitro and in vivo model of oxidative stress in the form of exogenous H2O2 and cerebral ischaemia, respectively. Increased levels of cell death were detected in primary neurons lacking Gpx1 following the addition of exogenous H2O2. This increased apoptosis correlated with a down-regulation in the activation of the phospho-inositide 3-kinase [PI(3)K]–Akt survival pathway. The importance of this pathway in protecting against H2O2-induced cell death was highlighted by the increased susceptibility of wildtype neurons to apoptosis when treated with the PI(3)K inhibitor, LY294002. The Gpx1–/– mice also demonstrated elevated neuronal cell death following MCA occlusion. Although Akt phosphorylation was detected in the Gpx1–/– brains, activation was not seen in later reperfusion events, as demonstrated in wildtype brains. Previous studies have highlighted the importance of Akt phosphorylation in protecting against neuronal cell death following cerebral ischaemia–reperfusion. Our results suggest that the increased susceptibility of Gpx1–/– neurons to H2O2-induced apoptosis and neuronal cell death in vivo following cerebral ischaemia–reperfusion injury can be attributed in part to diminished activation of Akt. Perturbations in key anti-apoptotic mechanisms as a result of an altered redox state may have implications in the study of oxidative stress-mediated neuropathologies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2004.02863.x
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  • 3
    Electronic Resource
    Electronic Resource
    Perioperative management of face-to-face craniopagus twins separation (2005)
    Oxford, UK : Blackwell Science Ltd
    Pediatric anesthesia 15 (2005), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Craniopagus conjoining represents a complex and challenging issue for neurosurgeons as well as for anesthesiologists. A rare face-to-face case of conjoined twins underwent surgical separation and presented peculiar differences compared with those already reported in the literature. Even in cases lacking large cerebrovascular sinus connections, the impending risk of large blood loss and hemorrhagic shock in the infant requires a high level of surveillance and the institution of invasive monitoring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9592.2004.01480.x
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  • 4
    Electronic Resource
    Electronic Resource
    Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 78 (2001), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Glutathione peroxidase is an antioxidant enzyme that is involved in the control of cellular oxidative state. Recently, unregulated oxidative state has been implicated as detrimental to neural cell viability and involved in both acute and chronic neurodegeneration. In this study we have addressed the importance of a functional glutathione peroxidase in a mouse ischemia/reperfusion model. Two hours of focal cerebral ischemia followed by 24 h of reperfusion was induced via the intraluminal suture method. Infarct volume was increased three-fold in the glutathione peroxidase-1 (Gpx-1) –/– mouse compared with the wild-type mouse; this was mirrored by an increase in the level of apoptosis found at 24 h in the Gpx-1 –/– mouse compared with the wild-type mouse. Neuronal deficit scores correlated to the histologic data. We also found that activated caspase-3 expression is present at an earlier time point in the Gpx-1 –/– mice when compared with the wild-type mice, which suggests an enhanced susceptibility to apoptosis in the Gpx-1 –/– mouse. This is the first known report of such a dramatic increase, both temporally and in level of apoptosis in a mouse stroke model. Our results suggest that Gpx-1 plays an important regulatory role in the protection of neural cells in response to the extreme oxidative stress that is released during ischemia/reperfusion injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00535.x
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  • 5
    Electronic Resource
    Electronic Resource
    Three further dolabellane diterpenoids from Dictyota sp.
    Amsterdam : Elsevier
    Phytochemistry 23 (1984), S. 1681-1684 
    Details
    ISSN: 0031-9422
    Keywords: Dictyota ; Phaeophyceae ; brown alga ; diterpenes ; dolabellane derivatives.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)83468-8
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  • 6
    Electronic Resource
    Electronic Resource
    The fracture energy (G F) of high-strength concretes (1993)
    Springer
    Materials and structures 26 (1993), S. 381-386 
    Details
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Description / Table of Contents: Resume On analyse les résultats de l’énergie de rupture de bétons présentant des niveaux de résistance à la compression allant jusqu’à 100 MPa. On a déterminé l’énergie de ruptureG F selon la recommandation de la Commission Technique RILEM 50-FMC. Les principales variables étudiées étaient les suivantes: niveaux de résistance, types et textures des granulats. On analyse les propriétés des mélanges obtenus avec différents types de gros granulats et une distribution granulométrique égale: trois granulats concassés (basalte, granit et calcaire) et deux graviers. On a mesuré aussi la résistance à la compression, le module d’élasticité et la résistance à la traction par fendage et par flexion de chaque béton. On a vérifié l’influence de la dimension des granulats sur l’énergie de ruptureG F, laquelle augmente encore avec la résistance du béton dans les domaines de haute résistance. Pour les bétons avec des granulats de 16 mm, on a mesuré des valeurs de l’énergie de ruptureG F proches de 200 N m−1. Les résultats obtenus sont comparés avec les valeurs indiquées dans le dernier Model Code du CEB.
    Notes: Abstract This paper presents results for the fracture energy of concrete (G F) obtained from a wide range of high-strength concretes. Strength levels up to 100 MPa, aggregate type and aggregate surface texture were included as variables. The determination ofG F was performed according to the recommendation of the RILEM 50-FMC Committee. Compressive and tensile strengths and the modulus of elasticity are also presented. Measured values ofG F are compared with those proposed in the last CEB Model Code.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02472938
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  • 7
    Electronic Resource
    Electronic Resource
    Experimental hydrocephalus following mechanical increment of intraventricular pulse pressure (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 1470-1472 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Experimental hydrocephalus has been induced in lambs by artificial increase of the amplitude of intraventricular cerebrospinal fluid (CSF) oscillations related to arterial pulsations, without concominant changes of the mean CSF-pressure. The characteristics of this hydrocephalus demonstrate that the intraventricular CSF-pulsations can play a role in the genesis of ventricular dilatation. Such a method may be used to produce an original model of hydrocephalus independent of changes of CSF-circulation or absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01918814
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  • 8
    Electronic Resource
    Electronic Resource
    Surgical indications in normotensive hydrocephalus. A retrospective analysis of the relations of some diagnostic findings to the results of surgical treatment (1976)
    Springer
    Acta neurochirurgica 33 (1976), S. 1-21 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty two of fifty five patients initially suspected of suffering from normotensive hydrocephalus were surgically treated (CSF ventriculoatrial shunt). The results of surgery were related to the findings of the different diagnostic examinations (pneumoencephalography, isotope cisternography, transfer from CSF to blood of isotope labelled serum albumin, constant infusion manometric test, long lasting intraventricular pressure recording). 1. Pneumoencephalography, intraventricular pressure recording, and, above all, isotope cisternography provided the most reliable data for diagnosis and surgical prognosis. 2. The combined use of pneumoencephalography and isotope cisternography was sufficient for a correct diagnosis and surgical prognosis in about 50% of the patients examined. 3. When the diagnostic information given by the combined results of the two above examinations was not sufficient, intraventricular pressure recording proved to be the most useful examination to supplement it. 4. The relation of the results of the study of transfer of isotope labelled serum albumin from CSF to blood and of the constant infusion manometric test to the surgical outcome was uncertain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405737
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  • 9
    Electronic Resource
    Electronic Resource
    Surgical treatment of late neurological deterioration in children with myelodysplasia (1995)
    Springer
    Acta neurochirurgica 137 (1995), S. 199-206 
    Details
    ISSN: 0942-0940
    Keywords: Tethered spinal cord ; spinal dysraphism ; magnetic resonance imaging ; post-repair myelomeningocele
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Late deterioration of the neurological condition in patients operated on for myelomeningocele repair has been repeatedly reported in the literature. At the present time magnetic resonance imaging (MRI) allows one to recognize various pathological conditions which can be amenable to surgical correction in these patients, such as Chiari type II malformation, hydro/syringomyelia, decompensated hydrocephalus, and tethered spinal cord. The authors report their experience with 26 myelodysplastic children operated on for myelomeningocele repair in the early neonatal period, who exhibited late deterioration at variable time intervals from the first operation. The children were examined pre-operatively by means of MRI; the results were compared with those provided by MRI in 46 myelodysplastic children who underwent the investigation as a routine follow-up control. The MRI findings were subdivided into 4 main groups of increasing severity from 1 to 4; in some subjects, associated pathological conditions (Chiari II malformation, hydromyelia, etc.) were detected as well. Twenty-two out of the 26 patients with late neurological deterioration were operated on. Eleven of them (grades 2 to 4) underwent detethering of the fixed conus, with an improvement of their clinical picture from mild to good. On the other hand the remaining 11 subjects (grades 1 to 2) improved their condition following the correction of the associated abnormalities (malfunctioning CSF shunt: 5 cases; hydromyelia: 4 cases; symptomatic Chiari II malformation: 2 cases).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02187194
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  • 10
    Electronic Resource
    Electronic Resource
    Cavernomas of the central nervous system in children (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1267-1274 
    Details
    ISSN: 0942-0940
    Keywords: Cavernoma ; children ; haemorrhage ; surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 22 patients under the age of 15 years with cavernomas were treated at the Section of Paediatric Neurosurgery of the Catholic University of Rome between 1981 and 1995. The most common symptoms at presentation were epilepsy, in 12 children, and intracranial hypertension, in 9 children; seizures were present on admission in 14 patients; no patient had a family history of cerebro-vascular malformations, two had multiple lesions. Radiological signs of significant acute and subacute haemorrhage were found in 17 cases. The supratentorial compartment was the most frequent location of the lesions, with only three subtentorial cavernomas. The post-surgical results were good: only four children had a persistence of pre-surgical neurological signs, even though they were ameliorated by the treatment. No patient showed a progression of pre-operative neurological signs, nor the onset of new deficits. Only one child died, but his clinical condition was critical before surgery, because of deep coma, with bilaterally dilated and fixed pupils, and no response to any stimulation. Our results suggest that the younger children present significant haemorrhage more frequently than the older ones; this is demonstrated by the analysis of the mean age of the patients with macro-haemorrhage (=7 years) and the average age of those without macro-haemorrhage (=11 years). The removal of cavernomas was always able to control the seizure disorders of our patients, proving that in these cases lesionectomy alone may be sufficient to resolve epilepsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411054
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