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  • 1
    Electronic Resource
    Electronic Resource
    Control of Translation by T4 Phage: Altered Binding of Disfavoured Messengers (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 820-823 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A messenger selection process operates in infected cell extracts at the level of polypeptide chain initiation; and the agent responsible is present chiefly in the factor fraction of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/226820a0
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  • 2
    Electronic Resource
    Electronic Resource
    Hormones and cell culture (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 113-114 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT is rare in science these days for a conference to be convened in memory of any one person, but such was the high regard in which Gordon Tomkins was held that the Sixth Cold Spring Harbor Meeting on Cell Proliferation* was convened in his memory in a field in which he was one of the father ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276113a0
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  • 3
    Electronic Resource
    Electronic Resource
    Preliminary X-ray crystallographic analysis of a Ca2+-binding protein human S100A1 (2001)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 57 (2001), S. 882-883 
    Details
    ISSN: 1399-0047
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: S100A1, a Ca2+-binding protein from the S100 protein family, has been crystallized by the vapour-diffusion method using polyethylene glycol 4000 as the precipitant at pH 8.5. The crystal belongs to space group P63. The unit-cell parameters are a = b = 57.3, c = 104.7 Å. There appear to be two S100A1 molecules in the asymmetric unit. The crystals were stable during exposure to X-rays and diffract to 2.6 Å resolution in-house.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0907444901005273
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  • 4
    Electronic Resource
    Electronic Resource
    Control of Translation by T4 Phage : Altered Ribosome Binding at R17 Initiation Sites (1970)
    [s.l.] : Nature Publishing Group
    Nature 226 (1970), S. 824-827 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] After infection of E. coli by T4 phage, ribosomes lose their ability to bind efficiently to the coat and synthetase initiation sites of R17 RNA. This change lies in the initiator factor ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/226824a0
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  • 5
    Electronic Resource
    Electronic Resource
    Late signals are required for the stimulation of DNA synthesis in rat mammary fibroblasts by growth factors (1996)
    Springer
    Bioscience reports 16 (1996), S. 249-263 
    Details
    ISSN: 1573-4935
    Keywords: bFGF ; EGF ; DNA synthesis ; signalling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Maximal stimulation of DNA synthesis in quiescent rat mammary (Rama) 27 fibroblasts is elicited by epidermal growth factor (EGF) or basic fibroblast growth factor (bFGF) 18 h after the initial addition of the growth factors-the ‘lag’ period. At maximally-stimulating concentrations, EGF and bFGF are interchangeable 9 h after their initial addition. When the initial concentration of growth factor is below that required to elicit a maximal response, it is possible to increase the level of DNA synthesis by increasing the concentration of growth factor 9 h after its initial addition. When the initial concentration of growth factor is high, substitution by a lower concentration of growth factor after 9 h allows a greater proportion of cells to synthesize DNA than would be expected from a continuous low dose of growth factor. Similar results are obtained when both the growth factor and its concentration are changed 9 h after the initial addition of growth factor. However, when EGF at a low concentration is substituted for a high concentration of EGF or bFGF the resulting increase in the levels of DNA synthesis is greater when EGF rather than bFGF is added for a second time. The half-life of the growth-stimulatory signals delivered by EGF and by bFGF 9 h after their initial addition is 1–2 h. These results suggest that to stimulate DNA synthesis: (i) EGF or bFGF must deliver a signal(s) continuously; (ii) the initial signals produced by EGF and bFGF are equivalent; (iii) the signals produced between 9–18 h by EGF may be different to those produced by bFGF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01207339
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  • 6
    Electronic Resource
    Electronic Resource
    Abnormal deposition of basement membrane and connective tissue components in dimethylbenzanthracene-induced rat mammary tumours: an immunocytochemical and ultrastructural study (1985)
    Springer
    Journal of molecular histology 17 (1985), S. 1155-1166 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Dimethylbenzanthracene-induced rat mammary tumours consist of lobules of tumours cells surrounded by connective tissue. The interstitial connective tissue proteins, collagen types I, III and V, fibronectin and elastin are largely restricted to the interlobular connective tissue. The tumour lobules are surrounded by a basement membrane that stains with antiserum to laminin. Electron microscopy reveals a greatly thickened basement membrane to which striated interstitial collagen fibres are closely juxtaposed. The lumina within the tumour lobules are of two types. In the first type, the luminal surface is characterized by the presence of microvilli and tight junctions are reacts with antiserum to rat milk fat globule membrane. In the second type, the luminal surface is flattened and lined by a thickened basement membrane that stains with antiserum to laminin and type IV collagen. These abnormal patterns of growth and differentiation may be partly a consequence of the disorganization of extracellular matrix components at the interface between the tumour epithelial cells and the surrounding stroma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002540
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  • 7
    Electronic Resource
    Electronic Resource
    Localization of vimentin in myoepithelial cells of the rat mammary gland (1989)
    Springer
    Journal of molecular histology 21 (1989), S. 679-685 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Myoepithelial cells in the virgin rat mammary gland have been shown to contain vimentin, using a polyclonal antiserum to vimentin purified from hamster fibroblasts. This antiserum has been shown to be specific for vimentin by immunoblotting and ELISA techniques. Similar results were obtained with a monoclonal antibody to vimentin. In the mammary glands of pregnant rats, the staining with vimentin antibodies is much weaker in the myoepithelial cells of the developing alveolar buds than in the main ducts. Similarly, in lactating glands, the staining of myoepithelial cells is much weaker in the secretory alveoli than in lactiferous sinuses. In each case, staining with antivimentin co-localizes with staining with polyclonal antisera to callous keratin (which specifically stain myoepithelial cells in the rat mammary gland).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01002489
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  • 8
    Electronic Resource
    Electronic Resource
    Immunolocalization of alpha-transforming growth factor in the developing rat mammary gland in vivo, rat mammary cells in vitro and in human breast diseases (1994)
    Springer
    Journal of molecular histology 26 (1994), S. 355-366 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunoreactive alpha-transforming growth factor (α-TGF) was shown by immunocytochemistry to be present in the rat mammary gland at various stages of development, the staining being most intense in mature myoepithelial cells. α-TGF was also detected in the secretions of the mammary glands of pregnant and lactating rats. α-TGF in the extracts of rat mammary glands at each stage of development, and in several rat mammary cell lines and in culture medium in which they had been grown, was shown by Western blotting to consist primarily of a protein of molecular weight 50 kDa. The amount of this protein was greater in the mammary gland of the lactating rat than in resting or involuting glands. α-TGF was also found in some, but not all, human breast carcinomas, and in benign hyperplastic breast diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00157769
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  • 9
    Electronic Resource
    Electronic Resource
    Interactions of putative heparin-binding domains of basic fibroblast growth factor and its receptor, FGFR-1, with heparin using synthetic peptides (1998)
    Springer
    Glycoconjugate journal 15 (1998), S. 419-422 
    Details
    ISSN: 1573-4986
    Keywords: fibroblast growth factor ; FGFR-1 ; heparin ; synthetic peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract We have examined structure-function relationships that have been proposed to account for the heparin-binding properties of basic fibroblast growth factor and its receptor, FGFR-1, using synthetic peptides, DNA synthesis assays and binding assays in a resonant mirror biosensor. The results suggest that the interaction of FGFR-1 with heparin may not be physiologically relevant and that the site of interaction of the polysaccharide on bFGF is more complex than has been anticipated. © 1998 Rapid Science Ltd
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006986104865
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  • 10
    Electronic Resource
    Electronic Resource
    Identification of Cell Types in the Developing Goat Mammary Gland (1999)
    Springer
    Journal of molecular histology 31 (1999), S. 379-393 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The goat was chosen as the model system for investigating mammary gland development in the ruminant. Histological and immunocytochemical staining of goat mammary tissue at key stages of development was performed to characterize the histogenesis of the ruminant mammary gland. The mammary gland of the virgin adult goat consisted of a ductal system terminating in lobules of ductules. Lobuloalveolar development of ductules occurred during pregnancy and lactation which was followed by the regression of secretory alveoli at involution. The ductal system was separated from the surrounding stroma by a basement membrane which was defined by antisera raised against laminin and Type IV collagen. Vimentin, smooth-muscle actin and myosin monoclonal antisera as well as antisera to cytokeratin 18 and multiple cytokeratins stained a layer of myoepithelial cells which surround the ductal epithelium. Staining of luminal epithelial cells by monoclonal antibodies to cytokeratins was dependent on their location along the ductal system, from intense staining in ducts to variable staining in ductules. The staining of epithelial cells by monoclonals to cytokeratins also varied according to the developmental status of the goat, being maximal in virgin and involuting glands, lowest at lactation and intermediate during gestation. In addition, cuboidal cells, situated perpendicular to myoepithelial cells and adjacent to alveolar cells in secretory alveoli, were also stained by cytokeratin monoclonal antibodies and antisera to the receptor protein, erbB-2, in similar fashion to luminal epithelial cells. These results demonstrate that caprine mammary epithelial cell differentiation along the alveolar pathway is associated with the loss of certain types of cytokeratins and that undifferentiated and secretory alveolar epithelial cells are present within lactating goat mammary alveoli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1003700224900
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