ISSN:
1432-1459
Keywords:
Alzheimer-type dementia
;
Senile plaque
;
Amyloid deposit
;
β-Protein
;
Immunohistochemistry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An immunohistochemical study with a polyclonal anti-β-protein antiserum was performed in order to understand the mechanism of deposition of amyloid fibrils in senile plaques in Alzheimer-type dementia (ATD). Serial cortical sections cut from ATD brains were necessary to investigate the structural correlation between senile plaques and blood vessels. The senile plaques were stained well and a blood vessel or capillary-like structure was found in most of β-protein-immunoreactive deposits. These findings may suggest an involvement of blood vessels in the formation of at least some of the amyloid deposits in ATD brains.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00314502
Permalink
