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  • 1
    Electronic Resource
    Electronic Resource
    Electric dipole transitions in Cl-like ions
    Amsterdam : Elsevier
    Atomic Data and Nuclear Data Tables 26 (1981), S. 467-475 
    Details
    ISSN: 0092-640X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0092-640X(81)90014-0
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  • 2
    Electronic Resource
    Electronic Resource
    Application of clinically recorded ICP patterns – an extension of conventional shunt testing (2000)
    Springer
    Child's nervous system 16 (2000), S. 856-861 
    Details
    ISSN: 1433-0350
    Keywords: Keywords Hydrocephalus ; Intracranial compliance ; Shunt evaluation ; Pressure/flow parameters ; Simulation of intracranial pressure patterns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Various methods of laboratory testing are currently being used to explore the hydrodynamic properties of shunts. We constructed a novel shunt-testing rig with a human-like compliance to be able to subject shunts to in-vivo recorded ICP patterns. The human-like situation was realized with a pear-shaped glass container with a non-linear, third-order pressure/volume characteristic similar to the CSF system. The new device also allows conventional shunt testing. Shunt performance in conventional pressure/flow tests (linear compliance) was compared to tests with human-like compliance. No clinically relevant differences were seen. Clinically recorded ICP waves (Lundberg type A and B) were reproduced before and after shunt implementation. Shunt insertion reduced pressure in the A-wave pattern to slightly negative values. Reproducing B-waves, the shunt dampened wave amplitude and pressure decreased below the opening pressure of the valve. In conclusion, the presented device allows a standardized reproduction of ICP patterns. The effects of shunt implantation can be studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003810000366
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  • 3
    Electronic Resource
    Electronic Resource
    Armplexusläsionen (1997)
    Springer
    Der Orthopäde 26 (1997), S. 665-665 
    Details
    ISSN: 1433-0431
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003425
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  • 4
    Electronic Resource
    Electronic Resource
    Time-dependent expression of donor- and host-specific major histocompatibility complex class I and II antigens in allogeneic dopamine-rich macro- and micrografts: comparison of two different grafting protocols (1997)
    Springer
    Acta neuropathologica 95 (1997), S. 85-97 
    Details
    ISSN: 1432-0533
    Keywords: Key words Parkinson’s disease ; Neural transplantation ; Allogeneic ; Major histocompatibility complex antigens ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neural transplantation, as a therapeutic approach to Parkinson’s disease, still requires allogeneic graft material and raises questions of immunosuppression and graft rejection. The present study investigated the time course of major histocompatibility complex (MHC) expression and astrocytic response in allogeneic dopaminergic grafts, comparing two different grafting protocols. Adult 6-hydroxydopamine-lesioned Lewis 1.W rats received intrastriatal cell suspension grafts from the ventral mesencephalon of DA rat fetuses, either as single 1-μl macrograft via metal cannula or as four micrografts of 250 nl/deposit via a glass capillary. No immunosuppression was administered. Immunohistochemistry was performed at 1, 3, 6, and 12 weeks after grafting, using antibodies against donor- and host-specific MHC class I and II antigen, glial fibrillary acidic protein (GFAP) and tyrosine hydroxylase (TH). Most animals showed good allograft survival up to 12 weeks after transplantation with no signs of rejection. Reinnervation of the lesioned striatum by TH-positive neurites was observed from 3–6 weeks on. Expression of donor-specific MHC class I was comparably low in both allogeneic grafting groups, while host MHC class I and II reaction as well as astrocytic response tended to be higher in the macrografted animals. Donor MHC class II was not observed at any time point. It is concluded that intraparenchymal allografts of fetal mesencephalic cell suspensions can survive well in the rat Parkinson model without immunosuppression for at least 12 weeks, and that the expression of moderate amounts of donor-specific MHC class I antigen does not suffice to initiate a rejection process. In addition, the microtransplantation approach may reduce the level of trauma and subsequent MHC and GFAP expression and may, thereby, minimize the risk of graft rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050769
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  • 5
    Electronic Resource
    Electronic Resource
    Dynamic properties of lymphatic pathways for the absorption of cerebrospinal fluid (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 493-498 
    Details
    ISSN: 1432-0533
    Keywords: Key words Cerebrospinal fluid absorption ; Lymphatic ; system ; Cisternography ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To study the dynamics of the outflow of cerebrospinal fluid (CSF) into the cervical lymphatic system, X-ray contrast medium or Indian ink was infused into the cisterna magna of rats at moderately increased intracranial pressure (40–50 mm Hg). In the first series of experiments, while the contrast medium was being infused, the animal’s head was examined using X-ray-microscopy (× 4–20 direct magnification radiography) and conventional radiography. Within the first minutes of infusion, the flow of CSF was directed from the posterior fossa to the olfactory bulb. Reaching the cribriform plate approximately 7 min after starting the infusion, the contrast medium leaked into the nasal cavities. Some minutes later, it opacified the subarachnoid space (SAS) of the optic nerve, the perilymphatic space of the inner ear, the cortical SAS, and the transverse sinuses. Leakage from the optic nerve SAS into the orbit was seen after 30 min infusion. In the second series of experiments, the Indian ink was infused after microsurgical exposure of the cervical lymph vessels. During the infusion the cervical lymph ducts were observed microscopically (× 40 magnification). Single dye particles draining through the cervical lymph ducts appeared 20 min after the start of cisternal infusion. Their transport was rapid, and dependent on the respiratory cycle: during inspiration the particles moved at a speed of 10–20 mm/s, during expiration the movement stopped. Thus, rapid kinetics are demonstrated for the outflow of CSF and particles from the SAS into the cervical lymphatics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050738
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  • 6
    Electronic Resource
    Electronic Resource
    Somatosensory evoked potentials and intracranial pressure during chronic dilatation of an artificial extraparenchymal space-occupying lesion in cats (1993)
    Springer
    Acta neurochirurgica 122 (1993), S. 105-112 
    Details
    ISSN: 0942-0940
    Keywords: Space-occupying lesion ; somatosensory evoked potential ; intracranial pressure ; mass effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Somatosensory evoked potentials (SEP) and intracranial pressure (ICP) were studied in cats, suffering from a chronic spaceoccupying lesion produced by enlargement of an epidural balloon over the left sensomotory cortex. Our study shows that latency alterations of SEP are not dependent on the degree of ICP. Additionally, the results obtained demonstrate that chronic space-occupying lesions cause continuous prolongation of SEP latencies, probably produced by atrophy of the compressed tissue. Regarding the clinical importance of SEP measurements, we concluded that they are not suitable for estimating the degree of ICP. However, they are useful to evaluate tissue damage caused by mass effects in the acute and chronic phase of various space-occupying processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01446995
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  • 7
    Electronic Resource
    Electronic Resource
    Indication, technique and results of facial nerve reconstruction (1994)
    Springer
    Acta neurochirurgica 130 (1994), S. 125-139 
    Details
    ISSN: 0942-0940
    Keywords: Facial nerve paralysis ; facial nerve reconstruction ; facio-facial nerve anastomosis ; hypoglossal-facial nerve anastomosis ; nerve transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 160 patients with various intraor extracranial pathologies were treated by microsurgical facial nerve reconstruction at Nordstadt Neurosurgical Clinic between 1978 and 1993. Facial nerve reconstruction was accomplished along the anatomical course of the facial nerve from its origin at the brainstem, within the mastoid, at the stylomastoid foramen and within the face. Mostly, reconstruction was indicated because of nerve discontinuity (n=61), whereas facial nerve reanimation with a donor nerve such as the contralateral facial nerve or the ipsilateral hypoglossal nerve was indicated in 99 cases of loss of a proximal nerve stump. Depending on the site of the lesion reinnervation started at 5 to 15 months postoperatively lasting for 2 to 3 years with overall satisfactory results. 69% of all the patients regained good symmetry on rest, complete eye closure equivalent to House-Brackmann-Score III: Patients with complete failures either suffered of non-related diseases such as cancer leading to death before the estimated time of recovery or were exposed to radiation or received facial nerve reconstruction after long-standing facial deficit and marked muscular atrophy. The indication of the adequate method depends on the clinical course with or without preexisting facial paresis, on considering the intraoperative state of the facial nerve, the identification and microsurgical preparation of adequate nerve stumps, as well as on the adaptation techniques and the postoperative guidance of the patient. We conclude that facial nerve reconstruction by transplantation at either site of the nerve course or by reanimation with a donor nerve are effective and reliable procedures of treatment leading to satisfactory functional and cosmetic results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405512
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  • 8
    Electronic Resource
    Electronic Resource
    Spinal chordomas — results of treatment over a 17-year period (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 514-519 
    Details
    ISSN: 0942-0940
    Keywords: Chordoma ; radiotherapy ; spinal neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among a series of 511 spinal tumours treated in the Department of Neurosurgery at the Nordstadt Hospital in Hannover, Germany, between September 1977 and August 1994, 23 operations for spinal chordomas in 9 patients (3 females, 6 males) were performed. After an average period of 7±12 months (2 weeks to 5 years) patients presented at an average age of 45±17 years with pain (68%), gait ataxia (14%), motor weakness (9%) or sphincter disturbances (9%). A complete resection was achieved in 11 operations and a subtotal tumour removal in 12 instances. After subtotal removal, 5 tumours were treated postoperatively using local high dose radiotherapy (60–70 Gy). Overall, every chordoma recurred with the passage of time unless en-bloc resection of the tumour had been performed. The recurrence-free interval tended to be longer after radiotherapy. Analysis of postoperative results revealed a significant positive effect of radiotherapy for motor function, pain, Karnofsky score, and survival. In conclusion, en-bloc resection should be performed whenever localization and extension of the tumour allow one to do so. Surgery should be followed by local high dose radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01411170
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  • 9
    Electronic Resource
    Electronic Resource
    Clinical value of percutaneous needle trephination (PNT) (1980)
    Springer
    Acta neurochirurgica 54 (1980), S. 181-189 
    Details
    ISSN: 0942-0940
    Keywords: Percutaneous needle trephination ; twist drill trephination ; CSF ; hydrocephalus ; ICP monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 56 neurosurgical patients 70 percutaneous needle trephinations were performed. This method was mostly used in patients with acute increase of ICP due to occlusive hydrocephalus of various aetiologies. Thanks to the accuracy and exhaustiveness of CT information, and thanks to the simplicity and safety of percutaneous needle trephination, this latter could be more and more used in daily clinical practice as a diagnostic and therapeutic procedure, for example for the study of adult hydrocephalus, for provisional external ventricular drainage, for treatment of CSF infections, and for ventricular bleedings (also in newborns and premature infants). No serious complication was seen even after prolonged CSF drainage over a period of 41 days. The method of PNT, as described in detail, can be used under sterile conditions at the bedside, on the stretcher in the emergency room, or in the CT or X-ray laboratory. It fulfils the criteria for clinical acceptance: simplicity, low risk, reliability, exactness, and effectiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407084
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  • 10
    Electronic Resource
    Electronic Resource
    Klinische, elektromyographische und quantitativ histologische Untersuchungen nach Nerventransplantation (1974)
    Springer
    Acta neurochirurgica 30 (1974), S. 1-29 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We have investigated whether the use of very short autogenous or of freeze dried homologous nerve grafts produced demonstrable differences in the regeneration results, such as could influence the indications and technique in repairing small nerve defects. For this purpose, clinical, electromyographic and quantitative histological animal experiments have been undertaken in rabbits over a time course of 17 weeks. The following groups were compared: 1. Transplantation of 5 mm autogenous grafts in 27 rabbit sciatic nerves. 2. Transplantation of 5 mm freeze-dried homologous grafts in 26 rabbit sciatic nerves while the following groups served as controls: 3. 26 sciatic nerves were severed and repaired by end-to-end suture. 4. 8 sciatic nerves were leftin situ without suture after simple section. Despite their short length, the freeze dried homologous grafts were definitely inferior to the autogenous grafts as judged by all the parameters employed. Thus, it appears that the use of very short homologous nerve grafts introduces distinct disadvantages.
    Notes: Zusammenfassung Es wird untersucht, ob bei der Verwendung sehr kurzer autologer und konservierter homologer Transplantate noch unterschiedliche Restitutionsergebnisse nachweisbar sind, was die Indikationsstellung bei der Überbrückung kleiner Nervendefekte erheblich beeinflussen könnte. Klinische, elektromyographische und quantitativ histologische tierexperimentelle Untersuchungen wurden zu diesem Zweck über einen Zeitraum von 17 Wochen an Kaninchenischiadici vorgenommen. Folgende Untersuchungsgruppen wurden verglichen: 1. Transplantation 5 mm langer autologer Transplantate bei 27 Kaninchenischiadici. 2. Transplantation 5 mm langer homologer Transplantate bei 26 Kaninchenischiadici. Als Kontrollgruppen dienten: 3. 26 Ischiadici, die durchtrennt und End-zu-End vernäht wurden, und 4. 8 Ischiadici, die nach einfacher Durchtrennung ungenäht im Situs belassen wurden. Die homologen Transplantate erwiesen sich trotz ihrer geringen Länge den autologen in allen angewandten Parametern deutlich unterlegen. Somit scheint auch die Verwendung sehr kurzer homologer Interponate erhebliche Nachteile mit sich zu bringen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405752
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