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  • 1
    Electronic Resource
    Electronic Resource
    Feeding augments canine jejunal absorption via a hormonal mechanism (1981)
    Springer
    Digestive diseases and sciences 26 (1981), S. 961-965 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to determine whether hormones mediate the postprandial increase in absorption of water, glucose, and electrolytes that occurs in the canine jejunum. In four dogs, a 75-cm isolated loop of jejunum was extrinsically denervated by autotransplantation. After recovery, the loop was perfused at 2.8 ml/min with an isotonic solution of 130 mM glucose, 80 mM NaCl, and trace amounts of [14C]PEG. Mean transit times through the loop were assessed concurrently with 0.5-ml boluses of [3H]PEG. Experiments were performed during fasting and after an oral meal of 200 g liver. Under steady-state conditions, net absorption of water, glucose, sodium, and chloride was greater after feeding than during fasting. In contrast, mean transit times were nearly identical during fasting and after feeding. We concluded that the augmentation of jejunal absorption of water, glucose, and the electrolytes after feeding was brought about by mechanisms other than alterations in transit time or effects induced via the extrinsic nerves. The augmentation appeared to be mediated, in part, by hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314755
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Ricinoleic acid causes secretion in autotransplanted (extrinsically denervated) canine jejunum (1981)
    Springer
    Digestive diseases and sciences 26 (1981), S. 966-970 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To examine the role of extrinsic nerves and hormones in intestinal secretion of fluid, we studied the effect of ricinoleic acid on absorption by isolated, autotransplanted jejunal loops in four dogs. Compared to perfusion with control solution, the addition of ricinoleic acid caused reversible secretion of water and electrolytes and inhibition of glucose absorption, as previously described in the innervated intestine. In contrast, oral castor oil caused diarrhea but had no effect on absorption from the denervated loop. Thus, the secretory action of ricinoleic acid is maintained without the influence of extrinsic nerves; in addition, further support is added to the proposal that hormones do not mediate secretion, in this model. These findings support a local mechanism for the secretion induced by ricinoleic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314756
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Motilin regulation of canine interdigestive intestinal motility (1983)
    Springer
    Digestive diseases and sciences 28 (1983), S. 249-256 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective was to determine whether motilin regulates cyclical interdigestive motility in the jejunum as well as in the duodenum. In four conscious dogs with an intact innervated duodenum, an autotransplanted (extrinsically denervated) 75-cm loop of proximal jejunum, and an autotransplanted,in situ distal jejunum, interdigestive myoelectrical complexes cycled independently in all three regions of small bowel. Plasma concentration of motilin was greater during phase III of the duodenal cycles (304±37 pg/ml) than during phase I (235±37 pg/ml) or phase II (235±39 pg/ml;P〈0.05), but the concentration did not vary consistently with the phases of the cycles in the autotransplanted jejunal segments. Intravenous infusions of motilin (0.6 μg/kg/min for 5 hr), begun 15–30 min after passage of phase III through the duodenum, shortened the interval between phase IIIs in the duodenum from 147±14 min before infusions to 44±3 min during the infusions (P〈0.05), but did not alter consistently the interval between phase IIIs in the autotransplanted jejunal segments. Feeding decreased plasma motilin concentration. The data were consistent with motilin regulation of interdigestive motility in intact, innervated canine duodenum but not in extrinsically denervated jejunum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01295120
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Hemosuccus pancreaticus complicating chronic pancreatitis: an obscure cause of upper gastrointestinal bleeding (2000)
    Springer
    Langenbeck's archives of surgery 385 (2000), S. 124-128 
    Details
    ISSN: 1435-2451
    Keywords: Key words Hemosuccus pancreaticus ; Hemoductal pancreatitis ; Wirsungorrhage ; Pancreatic duct hemorrhage ; Upper gastrointestinal bleeding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background: Hemosuccus pancreaticus, a rare form of upper gastrointestinal bleeding, may complicate chronic pancreatitis and pose a significant diagnostic and therapeutic dilemma. Aim: To present our experience with this potentially life-threatening complication of chronic pancreatitis. Methods: We reviewed our experience with management (both operative as well as angiographic embolization) of patients with hemosuccus pancreaticus complicating histologically documented chronic pancreatitis between 1976 and 1997. Diagnosis of hemosuccus pancreaticus was based on clinical presentation, preoperative endoscopic and radiographic imaging, operative findings, and pathologic evaluation. Results: During the period, we managed eight patients with hemosuccus pancreaticus (1.5% of all patients with chronic pancreatitis treated surgically). Gastrointestinal bleeding presented as hematemesis in three and hematochezia in three, but all had recent melena and were anemic; three of these patients were hemodynamically unstable. Abdominal pain was present in six. When performed, angiography (n=6) was diagnostic of a pseudoaneurysm; computed tomography (n=7) showed a pseudoaneurysm in two and a pseudocyst in five. Endoscopy (n=8) revealed blood issuing from the ampullary papilla in two patients. Operative management (n=6) involved distal pancreatectomy, pancreatoduodenectomy, or total pancreatectomy in two patients each. Angiographic embolization was successful in one patient, but the other died from uncontrollable hemorrhage. Conclusions: Hemosuccus pancreaticus is rare, but should be considered in patients with chronic pancreatitis and gastrointestinal bleeding. In the absence of pancreatitis-related indications for surgery, angiographic embolization can be definitive treatment. If there are pancreatitis-related indications for operation, angiographic embolization may allow an elective operative procedure based on structural changes of the pancreas. If embolization fails, pancreatic resection is usually required, often on an emergent basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004230050254
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    Paper (German National Licenses)
    Fulltext
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