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  • 1
    Electronic Resource
    Electronic Resource
    Repeated circadian growth hormone, luteinizing hormone, and follicle-stimulating hormone in children: Influence of 9-alpha-fluorohydrocortisone (1976)
    Springer
    European journal of pediatrics 122 (1976), S. 75-84 
    Details
    ISSN: 1432-1076
    Keywords: GH, LH, and FSH in plasma of children, repeated circadian patterns, intra-individual reproducibility, influence of 9-alpha-F ; Pubertal changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wachstumshormon (GH) und Gonadotropine (LH, FSH) wurden im Plasma von 5 Kindern verschiedener Pubertätsentwicklung und mit leichtem orthostatischem Syndrom radioimmunologisch (RIA) gemessen. Als Parameter dienten Argininbelastung und die Spiegel über 24 h gemessen stündlich von 8 bis 20 Uhr und halbstündlich von 20 bis 8 Ubr vor und nach sechswöchentlicher Behandlung mit 9-alpha-Fluorhydrocortison (9-alpha-F, Astonin-H®, Fa. Merck, Darmstadt, 0,1–0,2 mg/Tag). Die Werte für GH blieben unverändert, dagegen waren die circadianen Werte für LH nach Therapie leicht erhöht bei allen Kindern. Abhängig vom Pubertätsstadium nahmen Häufigkeit und Höhe der circadianen GH-Spitzen bei den drei Jungen zu, bei den zwei Mädchen gegen Ende der Pubertät eher ab. Schwankungen des LH und FSH waren im Schlaf deutlicher und nahmen bei den Jungen mit der Pubertät zu. Zwischen den beiden circadianen Kurven der einzelnen Kinder bestand eine deutliche Ähnlichkeit bei GH und LH, nicht aber bei FSH. Ein zeitlicher Zusammenhang der Spitzen von GH und LH fällt auf. Eine endogene, erbliche Langzeitregulation wird diskutiert.
    Notes: Abstract Growth hormone (GH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in plasma of 5 children at different pubertal stages and suffering from moderate orthostatic complaints, were measured by radioimmunoassay (RIA). Parameters for secretory capacity were arginine loading and circadian hormonal patterns in hourly intervals from 8 a.m. to 8 p.m. and in half-hourly intervals from 8 p.m. to 8 a.m. before and after 6 weeks treatment with 9-alpha-fluorohydrocortisone (9-alpha-F, Astonin-H, Fa. Merck, Darmstadt, 0.1–0.2 mg/day). Plasma GH during arginine tests and in circadian levels remained unchanged, but circadian LH showed a consistent slight rise in all children. With pubertal development, magnitude and timing of GH peaks increased in boys, and rather decreased in the two girls toward late puberty. Episodic fluctuation of LH and FSH were more marked during sleep, and increased in the three boys as puberty advanced. Similar intraindividual patterns for GH and LH, but not for FSH were noted in 4 children. Timing of GH and LH peaks appeared to be correlated. An intrinsic hereditary long-term regulatory principle is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445033
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  • 2
    Electronic Resource
    Electronic Resource
    Invited editorial comment: Neonatal thyroid screening (1984)
    Springer
    European journal of pediatrics 143 (1984), S. 6-6 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442738
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  • 3
    Electronic Resource
    Electronic Resource
    Short-term, high-dose testosterone treatment fails to reduce adult height in boys with constitutional tall stature (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 911-915 
    Details
    ISSN: 1432-1076
    Keywords: Key words Constitutional tall stature ; Short-term ; high-dose testosterone treatment ; Adult height ; Height predictions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Height predictions based on three different methods (Bayley-Pinneau [BP], Tanner-Whitehouse Mark II [TW II], Roche-Wainer-Thissen [RWT]) were compared to adult heights in 19 males with constitutional tall stature previously treated with high-dose testosterone oenanthate for 6 months (group A) and 25 untreated tall males (group B). Their chronological ages (CA) at the initial evaluation of tall stature ranged from 12.1 to 16.6 years in group A and from 10.4 to 15.7 years in group B; at the time of assessment of adult height ages ranged from 18.0 to 26.5 years and from 18.4 to 25.1 years, respectively. Height measurements and predicted adult heights were expressed as height standard deviation scores (height SDS) for chronological age using the tables of Reinken and van Oost [14]. Height SDS in group A were 2.8 (range = 1.8–5.4) before testosterone treatment, 3.0 (range = 2.0–4.8) thereafter and finally 3.0 (range = 2.1–4.2) (P=NS) and in group B 2.7 (range = 0.5–4.3) and 2.4 (range = 1.3–3.5) (P=NS). A significant difference between adult height SDS and predicted height SDS according to BP was detected both in group A (3.0; range = 2.1–4.2 vs 3.6; range = 2.4–5.0; P≤0.004) and group B (2.4; range = 1.3–3.5 vs 3.0; range = 2.0–4.9; P≤0.0002), whereas no significant difference between adult height SDS and predicted height SDS according to TW II and RWT was found in either group. These data indicate that BP height predictions overestimated adult height in our patient group of treated and untreated males with constitutional tall stature. In contrast, the TW II and RWT methods were more accurate in predicting adult height in these patients, but also failed to demonstrate that testosterone therapy in boys with constitutional tall stature can be limited to a 6-month period in order to reduce adult height. Conclusion The widely used height prediction method of BP is inaccurate in boys with constitutional tall stature. High dose testosterone treatment fails to reduce adult height in these individuals when discontinued before complete closure of the epiphyses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050741
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  • 4
    Electronic Resource
    Electronic Resource
    Neonatal mass screening for metabolic disorders (1981)
    Springer
    European journal of pediatrics 137 (1981), S. 133-139 
    Details
    ISSN: 1432-1076
    Keywords: Screening ; Neonatal mass screening ; Metabolic disorders ; Hypothyroidism ; Hyperphenylalaninaemia ; Galactosaemia ; Maple syrup urine disease ; Adrenogenital syndrome ; Cystic fibrosis ; Duchenne's muscular dystrophy ; Histidinaemia ; Hypermethioninaemia ; Tyrosinaemia ; Haemoglobinopathies ; Glucose-6-phosphate dehydrogenase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present situation of neonatal mass screening for metabolic disorders in eleven European countries is presented. The only disease screened for on a population wide basis in almost all countries is phenylketonuria. Screening for congenital hypothyroidism has been started in most countries or is under active consideration. A priority list of disorders that should be screened for routinely in all newborns comprises congenital hypothyroidism, hyperphenylalaninaemia, galactosaemia and maple syrup urine disease. Other disorders, like adrenogenital syndrome, cystic fibrosis. Duchenne's muscular dystrophy, histidinaemia, or tyrosinaemia cannot be recommended for mass screening at present because of an unsatisfactory test procedure or lack of effective treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441305
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  • 5
    Electronic Resource
    Electronic Resource
    Stunted growth with more or less normal appearance (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 214-238 
    Details
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442169
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  • 6
    Electronic Resource
    Electronic Resource
    Formation and decay of a modern massive sulfide deposit in the Indian Ocean (1998)
    Springer
    Mineralium deposita 33 (1998), S. 302-309 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract In December 1993, the first massive sulfides were recovered from the Indian Ocean floor, north of the Rodrigues Triple Junction. The polymetallic deposit is situated in the fourth Central Indian Ridge segment, close to the rift axis; it is hydrothermally no longer active. The deposit appears to be typical of mid-ocean ridge massive sulfide occurrences but is in a phase of disintegration and about to be buried by sediment. The chimney structures were formed by multiple hydrothermal events and are now degraded by mass wasting showing various stages of weathering. Later-stage, low-temperature hydrothermal mineralization processes led to copper and gold enrichment. Here we report on the geological setting, mineral zonation, different sulfide types and stages of formation of the “Sonne Sulfide Field”, which is part of a larger mineralized zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001260050149
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  • 7
    Electronic Resource
    Electronic Resource
    Hydrochemical evolution of Na-SO4-Cl groundwaters in a cold, semi-arid region of southern Siberia (1999)
    Springer
    Hydrogeology journal 7 (1999), S. 546-560 
    Details
    ISSN: 1435-0157
    Keywords: groundwater quality ; hydrochemical modelling ; salinisation ; Siberia ; semi-arid regions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Résumé La région de Shira en Khakassia, dans le sud de la Sibérie, présente de nombreux phénomènes déterminant la chimie des eaux souterraines et des eaux de surface qui sont communs aux régions froides et semi-arides du monde : (1) un climat continental, (2) une localisation à l'abri des pluies, (3) un drainage de surface à faible densité, (4) la présence de lacs salés et (5) l'existence d'une minéralisation évaporitique ancienne et actuelle. Dans les zones déprimées de Shira, les eaux souterraines et lacustres les plus salées ont un faciès sulfaté (et chloruré) sodique. Les résultats de la modélisation thermodynamique laissent penser qu'elles ont évolué sous l'effet combiné de l'altération de silicates et de la dissolution de halite et de gypse, associées à la précipitation de carbonates, qui a soustrait les ions calcium et bicarbonate. Un rapport sensiblement 1:1 des ions sodium et sulfate existe même dans les eaux souterraines des aquifères ne possédant pas d'évaporites. Ceci peut indiquer la formation d'évaporites secondaires de sulfate de sodium (dans et près des lacs ou dans les profils de sols lorsque la nappe est proche de la surface), qui sont ensuite dispersées à travers la région étudiée par transport atmosphérique. Plusieurs nappes de zones urbaines sont caractérisées par de très fortes concentrations en nitrate, provenant certainement d'infiltrations d'eaux usées.
    Notes: Abstract The Shira region of Khakassia in southern Siberia exhibits many features governing the evolution of groundwater and surface-water chemistry that are common to other cold, semi-arid areas of the world: (1) a continental climate, (2) location in a rain shadow, (3) low density of surface-water drainage, (4) occurrence of saline lakes, and (5) occurrence of palaeo- and modern evaporite mineralisation. In lowland areas of Shira, the more saline groundwaters and lake waters have a sodium-sulphate (-chloride) composition. Results of thermodynamic modelling suggest that these evolve by a combination of silicate weathering and gypsum and halite dissolution, coupled with carbonate precipitation to remove calcium and bicarbonate ions. An approximately 1:1 sodium:sulphate ratio occurs even in groundwaters from non-evaporite-bearing aquifers. This may indicate the formation of secondary sodium sulphate evaporites (in or near saline lakes or in soil profiles where the water table is shallow), which are subsequently distributed throughout the study area by atmospheric transport. Several urban groundwaters are characterised by very high nitrate concentrations, conceivably derived from sewage/latrine leakage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100400050228
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