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  • 1
    Electronic Resource
    Electronic Resource
    Iodinated 5- and 8-Hydroxyisoquinolines as Potential Amebicides (1966)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 9 (1966), S. 46-48 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00319a011
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Coal: Energy Keystone (1976)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Environment and Resources 1 (1976), S. 37-63 
    Details
    ISSN: 0362-1626
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.eg.01.110176.000345
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Current Status and Management of Fusiform Rust on Southern Pines (1981)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 19 (1981), S. 353-371 
    Details
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.py.19.090181.002033
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Wilms' tumor gene (WT1) expression in lung cancer, colon cancer and glioblastoma cell lines compared to freshly isolated tumor specimens (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 226-232 
    Details
    ISSN: 1432-1335
    Keywords: Key words Wilms' tumor gene expression ; Colon cancer ; Lung cancer ; Glioblastoma ; Cancer cell lines ; Cancer specimen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The Wilms' tumor gene (WT1) encodes a transcriptional regulator involved in growth and differentiation of various tissue types. A continuous over-expression of WT1 was found in leukemic blasts, thus suggesting an oncogenic function. Solid cancer entities have also been described as expressing WT1. We systematically analyzed WT1 expression in small-cell and non-small-cell lung cancer, colon cancer and glioblastoma patients and in the respective tumor cell lines. Using reverse transcription/polymerase chain reaction, we found WT1 expression in glioblastoma (5 of 8), lung (5 of 11), and colon cancer (5 of 15) cell lines. While WT1 was expressed in only 1 of 12 lung cancer and 1 of 5 glioblastoma specimens, it was not detected in colon cancer or macroscopically tumor-free colon and lung tissue. In addition, HT29 colon cancer cells showed a loss of WT1 expression when grown to confluence or induced to differentiate by sodium butyrate. From this evidence, testing for WT1 expression is not clinically relevant for colon cancer, lung cancer, or glioblastoma patients. WT1 expression in cancer cell lines can probably be attributed to optimized in vitro growth conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050037
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  • 5
    Electronic Resource
    Electronic Resource
    Restoration of voiding in chronic urinary retention using the neuroprosthesis (1991)
    Springer
    World journal of urology 9 (1991), S. 142-144 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six women and one man presenting with chronic urinary retention for 〉1 year were restored to normal voiding after implantation of a neuroprosthetic device. Detrusor contractions could not be elicited in a preoperative urodynamic investigation, and failure of urethral sphincter relaxation was noted in all cases. Test stimulation of the pudendal and sacral nerve roots resulted in normal motor responses. A temporary wire electrode was inserted in either the S3 or the S2 foramen and the patient was connected to a self-controlled pulse generator for 3–5 days. Voiding returned within the first 24 h and continued for the duration of the test. Retention recurred after removal of the temporary wire electrode. Permanent electrodes were then inserted. Five patients continue to void normally at 2–48 months (mean, 16 months) postimplantation. These subjects demonstrate that chronic retention can be the result of impaired reflex triggering of the voiding reflex in the presence of completely normal motor pathways. Sacral nerve root stimulation can identify this subset of patients and restore their normal voiding function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202509
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  • 6
    Electronic Resource
    Electronic Resource
    Editorial (1991)
    Springer
    World journal of urology 9 (1991), S. 109-109 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202501
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  • 7
    Electronic Resource
    Electronic Resource
    Neuromicturition (1991)
    Springer
    World journal of urology 9 (1991), S. 114-121 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neuroprosthetic approach for management of the spinal injury bladder is proving to be a valuable form of therapy. Stimulation of the ventral roots of S3–4, unilaterally or bilaterally, can effectively return control of bladder evacuation to a patient. The dorsal rhizotomy of the S2–4 nerves, performed at the same time as the electrode implant, has significant therapeutic benefit by itself. Bladder spasticity is reduced, which can correct reflux, restore continence, and decrease the risk of renal loss associated with urinary tract infection. Patients must be appropriately selected for the technique from a medical, psychological, urological and neurological point of view. Quality of life is greatly enhanced in these patients without significant risk. The following discussion addresses the evolution of and experience with the extradural method for implanting electrodes to control the spinal injury bladder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202504
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  • 8
    Electronic Resource
    Electronic Resource
    Surgical principles of sacral foramen electrode implantation (1991)
    Springer
    World journal of urology 9 (1991), S. 133-137 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuromodulation of sacral roots provides an alternative mode of treatment for patients presenting with voiding dysfunctions and chronic pelvic pain. To date, the implantation of permanent electrodes into the sacral foramen and long-term chronic stimulation have not resulted in peripheral nerve damage. In this paper, we describe the surgical technique used for sacral foramen electrode implantation. The nuances of this therapy are illustrated by case reports.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202507
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  • 9
    Electronic Resource
    Electronic Resource
    Neuromodulation of voiding dysfunction and pelvic pain (1991)
    Springer
    World journal of urology 9 (1991), S. 138-141 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuromodulation of sacral roots provides an alternative mode of therapy for patients presenting with voiding dysfunctions and chronic pelvic pain. Physiologically, this is accomplished by intervention in the neuronal pathways of micturition via sacral nerve-root electrical stimulation. Preoperative evaluation using temporary percutaneous sacral root stimulation selects the patients who are most likely to benefit from permanent electrode implantation. To date, no evidence of peripheral nerve damage has been recorded. Our experience with 〉1500 percutaneous tests and 150 permanent foramen implant procedures documents the safety and efficacy of this technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202508
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  • 10
    Electronic Resource
    Electronic Resource
    Rapid movements with reversals in direction (1988)
    Springer
    Experimental brain research 69 (1988), S. 355-367 
    Details
    ISSN: 1432-1106
    Keywords: Rapid arm movements ; Motor programs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transformations of the underlying movement control of rapid sequential (reversal) responses were examined as the movement amplitude (Experiment 1) and moment of inertia (Experiment 2) were altered, with constant movement time. Increases in amplitude and inertia were both met by sharply increased joint torques with a constant temporal structure, suggesting that the alterations may have been governed by a single gain parameter. The durations of various EMG bursts were essentially constant across changes in inertia, supporting a model in which the output of a fixed temporal representation is amplified to alter joint torques. The EMG amplitudes increased greatly with both amplitude and load. However, the fact that the EMG durations increased systematically with increases in distance provided difficulties for this model of amplitude control. The data suggest an economy in motor control in simple agravitational movements, whereby relatively simple transformations of an underlying representation can accomodate large changes in movement amplitude and moment of inertia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247580
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